Fibrous Hydrogels for Cell Encapsulation: A Modular and Supramolecular Approach.

Autor: Małgorzata K Włodarczyk-Biegun, Kambiz Farbod, Marc W T Werten, Cornelis J Slingerland, Frits A de Wolf, Jeroen J J P van den Beucken, Sander C G Leeuwenburgh, Martien A Cohen Stuart, Marleen Kamperman

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155625 (2016)

Artificial 3-dimensional (3D) cell culture systems, which mimic the extracellular matrix (ECM), hold great potential as models to study cellular processes under controlled conditions. The natural ECM is a 3D structure composed of a fibrous hydrogel t

Externí odkaz: https://doaj.org/article/ad46d24b9be74a4c91d186f62e916ed6

Precise Coating of a Wide Range of DNA Templates by a Protein Polymer with a DNA Binding Domain

Autor: Frits A. de Wolf, Marc W. T. Werten, Martien A. Cohen Stuart, Johan R. C. van der Maarel, Thomas H. LaBean, Renko de Vries, Nicole A. Estrich, Armando Hernandez-Garcia

Publikováno v: ACS Nano 11 (2017) 1
ACS Nano, 11(1), 144-152

Emerging DNA-based nanotechnologies would benefit from the ability to modulate the properties (e.g., solubility, melting temperature, chemical stability) of diverse DNA templates (single molecules or origami nanostructures) through controlled, self-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276b363a0fbc324267979e8e8036f6a9
https://doi.org/10.1021/acsnano.6b05938

Nanofibrillar hydrogel scaffolds from recombinant protein-based polymers with integrin- and proteoglycan-binding domains

Autor: Urszula Posadowska, Marc W. T. Werten, Marleen Kamperman, Frits A. de Wolf, Martien A. Cohen Stuart, Małgorzata K. Włodarczyk-Biegun, Sander C.G. Leeuwenburgh, Ingeborg M. Storm, Jeroen J.J.P. van den Beucken

Publikováno v: Journal of Biomedical Materials Research. Part a
Journal of Biomedical Materials Research Part A, 104, 12, pp. 3082-3092
Journal of Biomedical Materials Research Part A 104 (2016) 12
Journal of Biomedical Materials Research Part A, 104(12), 3082-3092
Journal of Biomedical Materials Research Part A, 104, 3082-3092

Contains fulltext : 171021.pdf (Publisher’s version ) (Open Access) This study describes the design, production, and testing of functionalized variants of a recombinant protein-based polymer that forms nanofibrillar hydrogels with self-healing prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265effb1de1845a69f33e7e4cd58d9f1
https://hdl.handle.net/2066/171021

Heparin as a Bundler in a Self-Assembled Fibrous Network of Functionalized Protein-Based Polymers

Autor: Ilse A. van Hees, Cornelis J. Slingerland, Marc W. T. Werten, Małgorzata K. Włodarczyk-Biegun, Martien A. Cohen Stuart, Renko de Vries, Marleen Kamperman, Frits A. de Wolf

Publikováno v: Biomacromolecules, 17(6), 2063-2072
Biomacromolecules 17 (2016) 6

Nature shows excellent control over the mechanics of fibrous hydrogels by assembling protein fibers into bundles of well-defined dimensions. Yet, obtaining artificial materials displaying controlled bundling remains a challenge. Here, we developed ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f0249b4ea3c6e9648ab4fb97bd1d7d
https://doi.org/10.1021/acs.biomac.6b00276

Pearl-necklace complexes of flexible polyanions with neutral-cationic diblock copolymers

Autor: Frits A. de Wolf, Martien A. Cohen Stuart, Renko de Vries, Armando Hernandez-Garcia, Monika D. Golinska

Publikováno v: Soft Matter 9 (2013) 28
Soft Matter, 9(28), 6406-6411

We study the complexation of very asymmetric diblock copolymers (consisting of a cationic block of 12 lysines connected to a 400 amino acid long hydrophilic polypeptide block with a net charge that is nearly zero) with oppositely charged sodium poly(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3594c73f8293c7734897a8ef12c22c
https://doi.org/10.1039/c3sm50536g