Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs.

Autor: Makarcyzk MJ; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering., Li ZA; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine; Department of Neurobiology, University of Pittsburgh School of Medicine; alanli@cuhk.edu.hk., Yu I; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine., Yagi H; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine., Zhang X; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine., Yocum L; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine., Li E; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine., Fritch MR; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine., Gao Q; Department of Orthopaedic Surgery, Stanford University., Bunnell BA; Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center., Goodman SB; Department of Orthopaedic Surgery, Stanford University; Department of Bioengineering, Stanford University., Tuan RS; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine; The Chinese University of Hong Kong., Alexander PG; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine; McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine., Lin H; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering; McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine; hal46@pitt.edu.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2023 Jan 27 (191). Date of Electronic Publication: 2023 Jan 27.

Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing.

Autor: Li Z; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA., Lin Z; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA., Liu S; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Yagi H; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA., Zhang X; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA., Yocum L; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA., Romero-Lopez M; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, 94305, USA., Rhee C; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, 94305, USA., Makarcyzk MJ; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, 15260, USA., Yu I; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA., Li EN; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, 15260, USA., Fritch MR; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA., Gao Q; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, 94305, USA., Goh KB; Institute of Physics, University of Freiburg, Freiburg, 79104, Germany.; School of Engineering, Monash University Malaysia, Selangor, 47500, Malaysia., O'Donnell B; Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, Orleans, LA, 70112, USA., Hao T; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA., Alexander PG; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA., Mahadik B; Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA., Fisher JP; Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA., Goodman SB; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, 94305, USA., Bunnell BA; Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, Orleans, LA, 70112, USA., Tuan RS; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, 15260, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA., Lin H; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, 15260, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Jul; Vol. 9 (21), pp. e2105909. Date of Electronic Publication: 2022 Apr 18.

Novel role of estrogen receptor-α on regulating chondrocyte phenotype and response to mechanical loading.

Autor: Wang N; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA; Department of Orthopaedic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China; Xiangya Third Hospital, Central South University, Changsha, Hunan, China. Electronic address: NINGW@pitt.edu., Zhang X; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA; Department of Orthopaedic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China; Xiangya Third Hospital, Central South University, Changsha, Hunan, China. Electronic address: XIURUI@pitt.edu., Rothrauff BB; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA. Electronic address: ben.rothrauff@gmail.com., Fritch MR; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA. Electronic address: MRF83@pitt.edu., Chang A; Department of Bioinformatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA. Electronic address: ALC217@pitt.edu., He Y; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA; Department of Orthopaedic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China; Xiangya Third Hospital, Central South University, Changsha, Hunan, China. Electronic address: YUCHE@pitt.edu., Yeung M; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 15219, USA. Electronic address: MEY38@pitt.edu., Liu S; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA. Electronic address: shl96@pitt.edu., Lipa KE; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 15219, USA. Electronic address: KEL159@pitt.edu., Lei G; Department of Orthopaedic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: lei_guanghua@csu.edu.cn., Alexander PG; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA. Electronic address: pea9@pitt.edu., Lin H; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 15219, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA. Electronic address: hal46@pitt.edu.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2022 Feb; Vol. 30 (2), pp. 302-314. Date of Electronic Publication: 2021 Nov 09.

Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells.

Autor: Xiang S; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China., Li Z; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Fritch MR; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Li; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Velankar S; Department of Chem/Petroleum Engineering and Mechanical Engineering & Materials Science, University of Pittsburgh Swanson School of Engineering, Pittsburgh, Pennsylvania, USA., Liu Y; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Sohn J; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Present Address: Biogen, Boston, Massachusetts, USA., Baker N; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Present Address: Department of Oral Biology, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania, USA., Lin H; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. hal46@pitt.edu.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. hal46@pitt.edu.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, Pennsylvania, USA. hal46@pitt.edu., Tuan RS; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. tuanr@cuhk.edu.hk.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. tuanr@cuhk.edu.hk.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, Pennsylvania, USA. tuanr@cuhk.edu.hk.; Present Address: Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. tuanr@cuhk.edu.hk.

Publikováno v: Stem cell research & therapy [Stem Cell Res Ther] 2021 Jun 14; Vol. 12 (1), pp. 347. Date of Electronic Publication: 2021 Jun 14.

Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling.

Autor: Li Z; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Xiang S; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Li EN; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, USA., Fritch MR; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Alexander PG; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lin H; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, USA., Tuan RS; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. tuanr@cuhk.edu.hk.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, USA. tuanr@cuhk.edu.hk.; Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. tuanr@cuhk.edu.hk.

Publikováno v: Handbook of experimental pharmacology [Handb Exp Pharmacol] 2021; Vol. 265, pp. 235-268.