Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Friso R. Postma"'
Autor:
Gautam B. Awatramani, Friso R. Postma, Greg D. Field, Amanda J. McLaughlin, David L. Paul, Jon Cafaro, Xiaoyang Yao
Direction-selective ganglion cells (DSGCs) deliver signals from the retina to multiple brain areas to indicate the presence and direction of motion. Delivering reliable signals in response to motion is critical across light levels. Here we determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f89ef1cb02a991008a81ad5ef48b19
https://europepmc.org/articles/PMC6293282/
https://europepmc.org/articles/PMC6293282/
Autor:
Leonie van Zeijl, Friso R. Postma, Aafke Ariaens, Nullin Divecha, Bas Ponsioen, Wouter H. Moolenaar, Kees Jalink, Ben N G Giepmans, Péter Várnai, Tamas Balla
Publikováno v:
Journal of Cell Biology, 177(5), 881-891. ROCKEFELLER UNIV PRESS
The Journal of Cell Biology
The Journal of Cell Biology
Cell-cell communication through connexin43 (Cx43)-based gap junction channels is rapidly inhibited upon activation of various G protein coupled receptors; however, the mechanism is unknown. We show that Cx43-based cell-cell communication is inhibited
Publikováno v:
Journal of Biological Chemistry. 276:8544-8549
Cell-cell communication via connexin-43 (Cx43)-based gap junctions is transiently inhibited by certain mitogens, but the underlying regulatory mechanisms are incompletely understood. Our previous studies have implicated the c-Src tyrosine kinase in m
Publikováno v:
Current Biology. 11:121-124
Loss of membrane potential (membrane depolarization) is one of the earliest and most striking responses of quiescent cells to stimulation with serum or G protein-coupled receptor (GPCR) agonists such as lysophosphatidic acid and thrombin [1–3]. Mem
Autor:
Wim J. van Blitterswijk, Kees Jalink, Marc C.M. van Dijk, Wouter H. Moolenaar, Friso R. Postma, Henk Hilkmann
Publikováno v:
Current Biology. 8(7):386-392
Background: Phospholipase D (PLD) hydrolyzes phospholipids to generate phosphatidic acid (PA) and a free headgroup. PLDs occur as both intracellular and secreted forms; the latter can act as potent virulence factors. Exogenous PLD has growth-factor-l
Autor:
E. Havik, O. Dalesio, Sjoerd Rodenhuis, Jos H. Beijnen, A. M. Westermann, Friso R. Postma, Wouter H. Moolenaar
Publikováno v:
Annals of oncology, 9(4), 437-442. Oxford University Press
Summary Background Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (SIP) are bioactive phospholipids with mitogenic and growth factor-like activities that act via specific cell-surface receptors present in many normal and transformed cell typ
Publikováno v:
The EMBO Journal. 15:2388-2392
Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid implicated in mitogenesis and cytoskeletal remodelling, but its mechanism of action is poorly understood. We report here that in N1E-115 neuronal cells, S1P mimics the G protein-coupled re
Autor:
Jacqueline Alblas, A. G. M. Bot, Kees Jalink, Friso R. Postma, H. R. De Jonge, Wouter H. Moolenaar, Trudi Hengeveld
Publikováno v:
The EMBO Journal. 15:63-72
Serum stimulation of quiescent fibroblasts leads to a dramatic depolarization of the plasma membrane; however, the identity of the active serum factor(s) and the underlying mechanism are unknown. We find that this serum activity is attributable to al
Publikováno v:
Drug Discovery for Psychiatric Disorders ISBN: 9781849733656
Autism and Autism Spectrum Disorders (ASD) are neurodevelopmental disorders affecting social skills, communication and behaviour. The prevalence of ASD is now recognized to be approximately 1:100. Although autism etiology is still largely undefined,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9afe7f024b4363de88293f8ea3485b83
https://doi.org/10.1039/9781849734943-00384
https://doi.org/10.1039/9781849734943-00384
Autor:
Marie-Françoise Simon, Hugues Chap, W J van Blitterswijk, Kees Jalink, G. A. Van Der Marel, Trudi Hengeveld, S Mulder, J. H. Van Boom, Wouter H. Moolenaar, Friso R. Postma
Publikováno v:
Biochemical Journal. 307:609-616
Lysophosphatidic acid (LPA; 1-acyl-sn-glycero-3-phosphate) is a platelet-derived lipid mediator that activates its own G-protein-coupled receptor to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types