Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Friedrich-Christian Deuschle"'
Autor:
Volker Morath, Corinna Brandt, Friedrich-Christian Deuschle, Claudia T. Mendler, Birgit Blechert, Dominik Summer, Cyril Barinka, Clemens Decristoforo, Wolfgang A. Weber, Markus Schwaiger, Arne Skerra
Publikováno v:
Molecular Pharmaceutics. 20:2490-2501
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce1dbf5d82b8a134f8cc4262ee2c0303
https://doi.org/10.1021/acs.molpharmaceut.2c01066
https://doi.org/10.1021/acs.molpharmaceut.2c01066
Publikováno v:
ChemBioChem. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6f4d8684aac596d866de55dae3b4355
https://doi.org/10.1002/cbic.202200795
https://doi.org/10.1002/cbic.202200795
Autor:
Brenda A. Schulman, Ulrich Keller, Katharina Götze, Mareike Verbeek, Jacob Stroh, Arne Skerra, Bernhard Kuster, Anna Kuisl, Simone Lemeer, Volker Morath, Michael Heider, Kheewoong Baek, Jana Zecha, Florian Bassermann, Martina Rudelius, Anne-Kathrin Garz, Vanesa Fernández-Sáiz, Johannes Buchner, Ruth Eichner, Wolfgang A. Weber, Jannis Lawatscheck, Friedrich-Christian Deuschle
Publikováno v:
Molecular Cell, 81(6), 1170. Cell Press
Molecular Cell
Molecular Cell
Summary The complex architecture of transmembrane proteins requires quality control (QC) of folding, membrane positioning, and trafficking as prerequisites for cellular homeostasis and intercellular communication. However, it has remained unclear whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea88a511b9db4500a360c1951b7081c
https://dspace.library.uu.nl/handle/1874/419636
https://dspace.library.uu.nl/handle/1874/419636
Publikováno v:
Expert opinion on biological therapy. 21(4)
Anticalin proteins are engineered versions of lipocalins that constitute a novel class of clinical-stage biopharmaceuticals. The lipocalins exhibit a central β-barrel with eight antiparallel β-strands and an α-helix attached to its side. Four stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f570d130f3130c9d88b598eabb99fb1
https://pubmed.ncbi.nlm.nih.gov/33074019
https://pubmed.ncbi.nlm.nih.gov/33074019
Autor:
Volker Morath, M. Schwaiger, Michael Heider, Arne Skerra, Sybille Reder, S. Ballke, Florian Bassermann, Friedrich-Christian Deuschle, Katja Steiger, Corinna Brandt, André Schiefner, Wolfgang A. Weber
Publikováno v:
58. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::752327bf010fab4438924808c9335787
https://doi.org/10.1055/s-0040-1708156
https://doi.org/10.1055/s-0040-1708156
Publikováno v:
Protein Science : A Publication of the Protein Society
The human CD98 heavy chain (CD98hc) offers a promising biomedical target both for tumor therapy and for drug delivery to the brain. We have previously developed a cognate Anticalin protein with picomolar affinity and demonstrated its effectiveness in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee925bb7f6a98f7a3fe718cb1573f64e
https://mediatum.ub.tum.de/doc/1578663/document.pdf
https://mediatum.ub.tum.de/doc/1578663/document.pdf
Development of a high affinity Anticalin® directed against human CD98hc for theranostic applications
Autor:
André Schiefner, Sybille Reder, S. Ballke, Corinna Brandt, Arne Skerra, Volker Morath, Wolfgang A. Weber, Markus Schwaiger, Friedrich-Christian Deuschle, Katja Steiger
Publikováno v:
Theranostics
Enhanced amino acid supply and dysregulated integrin signaling constitute two hallmarks of cancer and are pivotal for metastatic transformation of cells. In line with its function at the crossroads of both processes, overexpression of CD98hc is clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496d459f4650a179be98113a1d20a781
https://mediatum.ub.tum.de/1616130
https://mediatum.ub.tum.de/1616130
Publikováno v:
Proteins. 87(8)
The CD98 heavy chain (CD98hc) constitutes both a promising cell surface target for the treatment of cancers and a transcytosis receptor potentially useful for the brain delivery of therapeutics. However, pharmacokinetic studies and safety assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942ba6446b200cd7cf3378f838ec53d5
https://pubmed.ncbi.nlm.nih.gov/30958588
https://pubmed.ncbi.nlm.nih.gov/30958588