Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Friedrich-Alexander Ludwig"'
Autor:
Robert Wodtke, Markus Laube, Sandra Hauser, Sebastian Meister, Friedrich-Alexander Ludwig, Steffen Fischer, Klaus Kopka, Jens Pietzsch, Reik Löser
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-25 (2024)
Abstract Background Transglutaminase 2 (TGase 2) is a multifunctional protein and has a prominent role in various (patho)physiological processes. In particular, its transamidase activity, which is rather latent under physiological conditions, gains i
Externí odkaz:
https://doaj.org/article/22eb1f3fd9ac49ebabcd4cbb268205c3
Autor:
Friedrich-Alexander Ludwig, Erik Laurini, Judith Schmidt, Sabrina Pricl, Winnie Deuther-Conrad, Bernhard Wünsch
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 166 (2024)
σ1 receptors play a crucial role in various neurological and neurodegenerative diseases including pain, psychosis, Alzheimer’s disease, and depression. Spirocyclic piperidines represent a promising class of potent σ1 receptor ligands. The relatio
Externí odkaz:
https://doaj.org/article/0a3bc1da7d3848428725bd959f3c6d57
Autor:
Zhihuang Zheng, Dmitry Tsvetkov, Theda Ulrike Patricia Bartolomaeus, Cem Erdogan, Ute Krügel, Johanna Schleifenbaum, Michael Schaefer, Bernd Nürnberg, Xiaoning Chai, Friedrich-Alexander Ludwig, Gabriele N’diaye, May-Britt Köhler, Kaiyin Wu, Maik Gollasch, Lajos Markó
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Transient receptor potential channel subfamily C, member 6 (TRPC6), a non-selective cation channel that controls influx of Ca2+ and other monovalent cations into cells, is widely expressed in the kidney. TRPC6 gene variations have been linke
Externí odkaz:
https://doaj.org/article/eb5f803dda7d4cc3b54bebbbb62c7430
Autor:
Oliver Clauß, Linda Schäker-Hübner, Barbara Wenzel, Magali Toussaint, Winnie Deuther-Conrad, Daniel Gündel, Rodrigo Teodoro, Sladjana Dukić-Stefanović, Friedrich-Alexander Ludwig, Klaus Kopka, Peter Brust, Finn K. Hansen, Matthias Scheunemann
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 324 (2022)
The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitor
Externí odkaz:
https://doaj.org/article/830003203e3b458b81afb939ef4979aa
Autor:
Xiao-Ning Chai, Friedrich-Alexander Ludwig, Anne Müglitz, Yuanyuan Gong, Michael Schaefer, Ralf Regenthal, Ute Krügel
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3635 (2022)
TRPC6, the sixth member of the family of canonical transient receptor potential (TRP) channels, contributes to a variety of physiological processes and human pathologies. This study extends the knowledge on the newly developed TRPC6 blocker SH045 wit
Externí odkaz:
https://doaj.org/article/7f71462d1acb4d1c97d31c6d496f25e3
Autor:
Friedrich-Alexander Ludwig, Steffen Fischer, Richard Houska, Alexander Hoepping, Winnie Deuther-Conrad, Dirk Schepmann, Marianne Patt, Philipp M. Meyer, Swen Hesse, Georg-Alexander Becker, Franziska Ruth Zientek, Jörg Steinbach, Bernhard Wünsch, Osama Sabri, Peter Brust
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
(S)-[18F]fluspidine ((S)-[18F]1) has recently been explored for positron emission tomography (PET) imaging of sigma-1 receptors in humans. In the current report, we have used plasma samples of healthy volunteers to investigate the radiometabolites of
Externí odkaz:
https://doaj.org/article/7fa023e5037f427080aa634c67f8af79
Autor:
Rareş-Petru Moldovan, Daniel Gündel, Rodrigo Teodoro, Friedrich-Alexander Ludwig, Steffen Fischer, Magali Toussaint, Dirk Schepmann, Bernhard Wünsch, Peter Brust, Winnie Deuther-Conrad
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5447 (2021)
The σ2 receptor (transmembrane protein 97), which is involved in cholesterol homeostasis, is of high relevance for neoplastic processes. The upregulated expression of σ2 receptors in cancer cells and tissue in combination with the antiproliferative
Externí odkaz:
https://doaj.org/article/97524bcbd2024982a8bdf9445614e972
Autor:
Xiao-Ning Chai, Friedrich-Alexander Ludwig, Anne Müglitz, Michael Schaefer, Hai-Yan Yin, Peter Brust, Ralf Regenthal, Ute Krügel
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 259 (2021)
TRPC6 (transient receptor potential cation channels; canonical subfamily C, member 6) is widespread localized in mammalian tissues like kidney and lung and associated with progressive proteinuria and pathophysiological pulmonary alterations, e.g., re
Externí odkaz:
https://doaj.org/article/857134ea28d44a1f9293d9cd04aa5a8c
Autor:
Daniel Gündel, Masoud Sadeghzadeh, Winnie Deuther-Conrad, Barbara Wenzel, Paul Cumming, Magali Toussaint, Friedrich-Alexander Ludwig, Rareş-Petru Moldovan, Mathias Kranz, Rodrigo Teodoro, Bernhard Sattler, Osama Sabri, Peter Brust
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1645 (2021)
The expression of monocarboxylate transporters (MCTs) is linked to pathophysiological changes in diseases, including cancer, such that MCTs could potentially serve as diagnostic markers or therapeutic targets. We recently developed [18F]FACH as a rad
Externí odkaz:
https://doaj.org/article/5b1970c5d3d24d729de127e909248124
Autor:
Thu Hang Lai, Susann Schröder, Magali Toussaint, Sladjana Dukić-Stefanović, Mathias Kranz, Friedrich-Alexander Ludwig, Steffen Fischer, Jörg Steinbach, Winnie Deuther-Conrad, Peter Brust, Rareş-Petru Moldovan
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2285 (2021)
The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during t
Externí odkaz:
https://doaj.org/article/76b84321f4d2489c95d5100f3eac0c6c