Coupling of Immunostimulants to Live Cells through Metabolic Glycoengineering and Bioorthogonal Click Chemistry

Autor: Aline Mongis, Friedrich Piller, Véronique Piller

Publikováno v: Bioconjugate Chemistry
Bioconjugate Chemistry, American Chemical Society, 2017, 28 (4), pp.1151-1165. ⟨10.1021/acs.bioconjchem.7b00042⟩

International audience; The present study investigated the potential of metabolic glycoengineering followed by bioorthogonal click chemistry for introducing into cell-surface glycans different immunomodulating molecules. Mouse tumor models EG7 and MC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c191ca34b7c5622f43b5771e6ffc803
https://hal.archives-ouvertes.fr/hal-01618670

MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 1,6-N-acetylglucosaminyltransferase and -galactoside 2,3-sialyltransferase

Autor: Véronique Piller, Tomasz Owczarek, Piotr Dziegiel, Maciej Ugorski, Alicja Solatycka, Friedrich Piller, Marzena Podhorska-Okolow, Lukasz Wojciech, Bartosz Pula

Publikováno v: Glycobiology
Glycobiology, Oxford University Press (OUP), 2012, 22 (8), pp.1042-54. ⟨10.1093/glycob/cws075⟩

International audience; A good correlation between the expression of mucin1 (MUC1) and T antigen was found in breast cancer tumors and breast cancer cell lines, especially after treatment with neuraminidase. The association between the appearance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c3132000fa3618a05a66c8de9075ec
https://doi.org/10.1093/glycob/cws075

An Enzyme-Linked Immunosorbent Assay for Therapeutic Drug Monitoring of Cetuximab

Autor: Danielle Degenne, Gilles Paintaud, Nicolas Ceze, Hervé Watier, Etienne Dorval, Nicolas Azzopardi, Friedrich Piller, Thierry Lecomte, David Ternant

Publikováno v: Ther. Drug Monit.
Ther. Drug Monit., 2009, 31 (5), pp.597-601
Therapeutic Drug Monitoring
Therapeutic Drug Monitoring, Lippincott, Williams & Wilkins, 2009, 31 (5), pp.597-601

International audience; Cetuximab is anti-epidermal growth factor receptor monoclonal antibody used in the treatment of colorectal and head and neck cancers. Part of the interindividual differences in response may be explained by interindividual vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8712c8721d93e1454a6690542b619476
https://doi.org/10.1097/ftd.0b013e3181b33da3

Metabolic Glyco-Engineering in Eukaryotic Cells and Selected Applications

Autor: Friedrich, Piller, Aline, Mongis, Véronique, Piller

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1321

By metabolic glyco-engineering cellular glycoconjugates are modified through the incorporation of synthetic monosaccharides which are usually analogues of naturally present sugars. In order to get incorporated, the monosaccharides need to enter the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14cd1d5ac90cd004d1d27fa09166b28a
https://pubmed.ncbi.nlm.nih.gov/26082233

Synthesis and Biological Evaluation of a Multiantigenic Tn/TF-Containing Glycopeptide Mimic of the Tumor-Related MUC1 Glycoprotein

Autor: Gaëlle-Anne Cremer, Nicole Bureaud, Agnès F. Delmas, Véronique Piller, Horst Kunz, Friedrich Piller

Publikováno v: ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2006, 1 (9), pp.965-968. ⟨10.1002/cmdc.200600104⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504cf4f8635ab25a6dc10cda58065302
https://doi.org/10.1002/cmdc.200600104