Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Friedrich L. Joos"'
Autor:
Marie-Christin Jäger, Víctor González-Ruiz, Friedrich L. Joos, Denise V. Winter, Julien Boccard, Thorsten Degenhardt, Steve Brand, Serge Rudaz, George R. Thompson, Alex Odermatt
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The triazole antifungals posaconazole and itraconazole can cause pseudohyperaldosteronism with hypertension and hypokalemia, edema, and gynecomastia by inhibiting steroid synthesis and metabolism. Mechanisms underlying pseudohyperaldosteronism includ
Externí odkaz:
https://doaj.org/article/afe101840dac4196825e2d8599c4e6ac
Publikováno v:
Current Research in Toxicology, Vol 5, Iss , Pp 100119- (2023)
Azole antifungals, designed to inhibit fungal CYP51, have a liability to inhibit human CYP enzymes. Whilst drug-metabolizing CYPs are covered in preclinical safety assessment, those metabolizing endogenous bioactive molecules are usually not. Posacon
Externí odkaz:
https://doaj.org/article/f409fb4d1f5541d4862aba9eb1a7bcd3