Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Friedrich, Frischknecht"'
Autor:
Julia M Sattler, Lukas Keiber, Aiman Abdelrahim, Xinyu Zheng, Martin Jäcklin, Luisa Zechel, Catherine A Moreau, Smilla Steinbrück, Manuel Fischer, Chris J Janse, Angelika Hoffmann, Franziska Hentzschel, Friedrich Frischknecht
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2060-2079 (2024)
Abstract Malaria vaccination approaches using live Plasmodium parasites are currently explored, with either attenuated mosquito-derived sporozoites or attenuated blood-stage parasites. Both approaches would profit from the availability of attenuated
Externí odkaz:
https://doaj.org/article/7e8f8d388dbf473180a7d3d030a19d8f
Autor:
Friedrich Frischknecht
Friedrich Frischknecht gives an insight into malaria and the biological complexity of the parasites that trigger it. The author takes the reader on a journey from the historical discovery of the pathogen to the modern methods of vaccine development.
Autor:
Elena Levashina, Dominique Soldati‐Favre, Andrew P Waters, Friedrich Frischknecht, Julian C Rayner
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-4 (2023)
Graphical Abstract Round table discussion on challenges and opportunities in malaria research with Elena Levashina, Dominique Soldati‐Favre, Andrew Waters, Friedrich Frischknecht, and Julian Rayner.
Externí odkaz:
https://doaj.org/article/eab9fa6986ea4893a6d0164cceae1fc8
Autor:
Josie L. Ferreira, Vojtěch Pražák, Daven Vasishtan, Marc Siggel, Franziska Hentzschel, Annika M. Binder, Emma Pietsch, Jan Kosinski, Friedrich Frischknecht, Tim W. Gilberger, Kay Grünewald
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13 protofilaments arranged in a hollow cylinder. Using CryoEM and subvolume averaging, Ferreira and Pražák et al. show that Plasmodium does not adhere to a single
Externí odkaz:
https://doaj.org/article/1ec7f99f7ae54d35a6fecfd9f8a89cab
Autor:
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesén-Ramírez, Lilian Patrick Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny Wilson, Friedrich Frischknecht, Tim-Wolf Gilberger
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/2003f8bc3d7e413786beb48d0a785701
Autor:
Chi Ho Wai, Jessica Jin, Marek Cyrklaff, Christel Genoud, Charlotta Funaya, Julia Sattler, Aleksandra Maceski, Stephanie Meier, Sabine Heiland, Michael Lanzer, Friedrich Frischknecht, Jens Kuhle, Martin Bendszus, Angelika Hoffmann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Neurofilament light chain (NfL), released during central nervous injury, has evolved as a powerful serum marker of disease severity in many neurological disorders, including infectious diseases. So far NfL has not been assessed in cerebral m
Externí odkaz:
https://doaj.org/article/9bc59db04d294d8c88bf7bb472b2285c
Autor:
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesén-Ramírez, Lilian Patrick Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny Wilson, Friedrich Frischknecht, Tim-Wolf Gilberger
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Mature gametocytes of Plasmodium falciparum display a banana (falciform) shape conferred by a complex array of subpellicular microtubules (SPMT) associated with the inner membrane complex (IMC). Microtubule-associated proteins (MAPs) define
Externí odkaz:
https://doaj.org/article/710728579d33454a8219a2cfe937fc9a
Autor:
Konrad Beyer, Simon Kracht, Jessica Kehrer, Mirko Singer, Dennis Klug, Friedrich Frischknecht
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-12 (2021)
Abstract Background Plasmodium sporozoites are the highly motile forms of malaria-causing parasites that are transmitted by the mosquito to the vertebrate host. Sporozoites need to enter and cross several cellular and tissue barriers for which they e
Externí odkaz:
https://doaj.org/article/2050cfbe2e22467882b6624149238cf9
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010779 (2022)
Actin is one of the most conserved and ubiquitous proteins in eukaryotes. Its sequence has been highly conserved for its monomers to self-assemble into filaments that mediate essential cell functions such as trafficking, cell shape and motility. The
Externí odkaz:
https://doaj.org/article/13b4c86648fc464d87de89e590c2bb54
Autor:
Komal Soni, Georg Kempf, Karen Manalastas-Cantos, Astrid Hendricks, Dirk Flemming, Julien Guizetti, Bernd Simon, Friedrich Frischknecht, Dmitri I. Svergun, Klemens Wild, Irmgard Sinning
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
The SRP Alu domain is involved in co-translational protein targeting. Soni et al. investigate the Alu domain of Plasmodium falciparum, the agent of malaria, and find that unlike any other it adopts an open conformation.
Externí odkaz:
https://doaj.org/article/209bda6b89384eceb72f2290525335c3