Výsledky vyhledávání - "Friedhelm R, Schuster"

Expression of Surface-associated 82 kDa proMMP-9 in Lymphatic Leukemia Blast Cells Differentially Correlates With Prognosis

Autor: Helmut R. Salih, Friedhelm R. Schuster, Elena Pepeldjyika, Amely Hartmann, Helga Schmetzer, Johanna Tischer, Christian Ries, Corinna L Seidel, Joerg Uwe Schmohl, Doris Kraemer, Thomas Guenther, Sabine Moebius, Wishnu Sutanto

Publikováno v: Anticancer Research. 41:3891-3898

Background/aim Matrix metalloproteinases (MMPs) degrade extracellular matrix and process regulatory proteins. Recently, a membrane-bound 82kDa variant of proMMP-9 identified on myeloid blasts was shown to be associated with prognosis. Patients and me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de76a9491e6e1f26705b787a7b88300
https://doi.org/10.21873/anticanres.15184

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Akademický článek

Hematopoietic Stem Cell Transplantation in an Infant with Immunodeficiency, Centromeric Instability, and Facial Anomaly Syndrome

Autor: Katharina L. Gössling, Cyrill Schipp, Ute Fischer, Florian Babor, Gerhard Koch, Friedhelm R. Schuster, Jutta Dietzel-Dahmen, Dagmar Wieczorek, Arndt Borkhardt, Roland Meisel, Michaela Kuhlen

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Immunodeficiency, centromeric instability, and facial anomaly (ICF) syndrome is a rare autosomal recessive genetic condition with severe immunodeficiency, which leads to lethal infections if not recognized and treated in early childhood. Up-to-date t

Externí odkaz: https://doaj.org/article/fe981fc12f194d1ab62624a783dad0f2

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Akademický článek

Next-generation-sequencing-spectratyping reveals public T-cell receptor repertoires in pediatric very severe aplastic anemia and identifies a β chain CDR3 sequence associated with hepatitis-induced pathogenesis

Autor: Pina F. I. Krell, Susanne Reuther, Ute Fischer, Thomas Keller, Stephan Weber, Michael Gombert, Friedhelm R. Schuster, Corinna Asang, Polina Stepensky, Brigitte Strahm, Roland Meisel, Jens Stoye, Arndt Borkhardt

Publikováno v: Haematologica, Vol 98, Iss 9 (2013)

Current diagnostic approaches that characterize T-cell deficiency by analyzing diversity of T-cell receptor sequences effectuate limited informational gain about the actual restrictiveness. For deeper insight into T-cell receptor repertoires we devel

Externí odkaz: https://doaj.org/article/f52b7b115b8d48af8938eafb60742196

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Expression profiles of HMGB1 on B-CLL related leukocytes contribute to prediction of relapse

Autor: Helga Schmetzer, Oliver Stoetzer, Joerg Uwe Schmohl, Helmut R. Salih, Amely Hartmann, Thomas Guenther, Friedhelm R. Schuster, Tanja Kroell, Wishnu Sutanto

Publikováno v: Immunobiology. 226(1)

The High Mobility Group Box 1 (HMGB1) is a nuclear protein that is frequently overexpressed in hematologic diseases and might be of relevance in immunogenic cancer control thus correlating with patients' (pts.) prognosis in diseases such as acute mye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9e0bd899c39dd22a62d3db9a519023
https://pubmed.ncbi.nlm.nih.gov/33485134

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Akademický článek

CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL

Autor: Ute Fischer, Christian Ruckert, Bernd Hubner, Olaf Eckermann, Vera Binder, Tamam Bakchoul, Friedhelm R. Schuster, Sylvia Merk, Hans-Ulrich Klein, Monika Führer, Martin Dugas, Arndt Borkhardt

Publikováno v: Haematologica, Vol 97, Iss 9 (2012)

Background Very severe aplastic anemia is characterized by a hypoplastic bone marrow due to destruction of CD34+ stem cells by autoreactive T cells. Investigation of the pathomechanism by patient-specific gene expression analysis of the attacked stem

Externí odkaz: https://doaj.org/article/f00399b8fe6b4bb58aedf5218d8aa507

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