Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Friederike V Opitz"'
Autor:
Guillermo Rodríguez-Hernández, Friederike V. Opitz, Pilar Delgado, Carolin Walter, Ángel F. Álvarez-Prado, Inés González-Herrero, Franziska Auer, Ute Fischer, Stefan Janssen, Christoph Bartenhagen, Javier Raboso-Gallego, Ana Casado-García, Alberto Orfao, Oscar Blanco, Diego Alonso-López, Javier De Las Rivas, Sara González de Tena-Dávila, Markus Müschen, Martin Dugas, Francisco Javier García Criado, María Begoña García Cenador, Carolina Vicente-Dueñas, Julia Hauer, Almudena R. Ramiro, Isidro Sanchez-Garcia, Arndt Borkhardt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Infection or chronic inflammation is a risk factor for childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors show that the DNA editing enzyme AID is expressed in infected B cells but using genetic mouse models show that it does n
Externí odkaz:
https://doaj.org/article/8a5af14a1ec34d24b634ebc17db69869
Autor:
Kevin Sondenheimer, M. Majora, Jean Krutmann, Sonja Faßbender, Jennifer Schindler, Thomas Haarmann-Stemmann, Friederike V. Opitz, Marius Pollet, Heike Weighardt
Publikováno v:
Journal of Investigative Dermatology. 142:1183-1193
The transcription factor Hypoxia-Inducible Factor-1alpha (HIF-1a) regulates cellular metabolism under hypoxia but also immune responses and UVB-induced skin reactions. In keratinocytes, HIF-1a is an environmental sensor orchestrating the adaptation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de4d5a74c303a6b317e0c55d833e22e
https://doi.org/10.1016/j.jid.2021.07.185
https://doi.org/10.1016/j.jid.2021.07.185
Autor:
Sven-Thorsten Liffers, Laura Godfrey, Lisa Frohn, Lena Haeberle, Aslihan Yavas, Rita Vesce, Wolfgang Goering, Friederike V Opitz, Nickolas Stoecklein, Wolfram Trudo Knoefel, Anna Melissa Schlitter, Guenter Klöppel, Elisa Espinet, Andreas Trumpp, Jens T Siveke, Irene Esposito
ObjectiveDue to the limited number of modifiable risk factors, secondary prevention strategies based on early diagnosis represent the preferred route to improve the prognosis of pancreatic ductal adenocarcinoma (PDAC). Here, we provide a comparative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074c22adb675c2f6c682676c868fcfc8
https://www.ncbi.nlm.nih.gov/pubmed/35944927
https://www.ncbi.nlm.nih.gov/pubmed/35944927
Publikováno v:
Cancers
Cancers, Vol 13, Iss 6188, p 6188 (2021)
Cancers (Basel)
Cancers, Vol 13, Iss 6188, p 6188 (2021)
Cancers (Basel)
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive neoplasm with a poor survival rate. This is mainly due to late detection, which substantially limits therapy options. A better understanding of the early phases of pancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120fbf9a97be3b5bb4d812042d0a944c
http://europepmc.org/articles/PMC8699458
http://europepmc.org/articles/PMC8699458
Autor:
Michael Blank, Marc Beyer, Günter Mayer, Eicke Latz, Oliver Schanz, Markus Funke, Heike Weighardt, Julia Siegl, Joachim L. Schultze, Kristian Händler, Lorenz Fülle, Anna Belen Erazo, Silvana K. Haßel, H. James Stunden, Irmgard Förster, Fabian Gondorf, Franziska Pfeiffer, Carsten Gröber, Friederike V. Opitz, Nancy Steiner
Publikováno v:
Molecular therapy 26(1), 95-104 (2018). doi:10.1016/j.ymthe.2017.10.005
Molecular Therapy
Molecular Therapy
The chemokine CCL17, mainly produced by dendritic cells (DCs) in the immune system, is involved in the pathogenesis of various inflammatory diseases. As a ligand of CCR4, CCL17 induces chemotaxis and facilitates T cell-DC interactions. We report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fde5b717089cae15ace340021ee134
https://doi.org/10.1016/j.ymthe.2017.10.005
https://doi.org/10.1016/j.ymthe.2017.10.005
Autor:
Almudena R. Ramiro, María Begoña García Cenador, Diego Alonso-López, Arndt Borkhardt, Oscar Blanco, Ute Fischer, Javier Raboso-Gallego, Ana Casado-García, Francisco Javier García Criado, Franziska Auer, Sara González de Tena-Dávila, Inés González-Herrero, Isidro Sánchez-García, Martin Dugas, Carolina Vicente-Dueñas, Christoph Bartenhagen, Julia Hauer, Alberto Orfao, Javier De Las Rivas, Markus Müschen, Carolin Walter, Friederike V. Opitz, Stefan Janssen, Pilar Delgado, Guillermo Rodríguez-Hernández, Ángel F. Álvarez-Prado
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Instituto de Salud Carlos III (ISCIII)
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
The prerequisite to prevent childhood B-cell acute lymphoblastic leukemia (B-ALL) is to decipher its etiology. The current model suggests that infection triggers B-ALL development through induction of activation-induced cytidine deaminase (AID; also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54665f9a88ac44b6af5ae576d28511c8
http://hdl.handle.net/20.500.12105/8953
http://hdl.handle.net/20.500.12105/8953
Publikováno v:
European Journal of Immunology. 46:981-992
Atopic dermatitis (AD) is a chronic inflammatory disease controlled by the innate and adaptive immune system. To elucidate the impact of innate immune signaling in AD, we analyzed MyD88-deficient mice in a murine model of AD-like dermatitis by epicut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bebb062c82d43c822250023e2105a9fe
https://doi.org/10.1002/eji.201545710
https://doi.org/10.1002/eji.201545710
Autor:
Finn K. Hansen, Daniela Diedrich, Joachim Jose, Viktoria Marquardt, Friederike V. Opitz, Arndt Borkhardt, Hana Kunkel, Matthias U. Kassack, Luitgard Nagel-Steger, Florian Babor, Manuel Grez, Heinz Ahlert, Thomas Kurz, Stefan Stein, Ana J. Rodrigues Moita, Tobias Kröger, Sanil Bhatia, Steffen Lüdeke, Marina Oldenburg, Holger Gohlke, Bertan Bopp, Gesine Kögler, Andreas Hochhaus, Marc Remke, Franziska Lang, Julia Hauer, Andreas Krieg, Benedikt Frieg, Tao Zang, Georg Groth, Thomas Ernst
Publikováno v:
Blood. 132(3)
Heat shock protein 90 (HSP90) stabilizes many client proteins, including the BCR-ABL1 oncoprotein. BCR-ABL1 is the hallmark of chronic myeloid leukemia (CML) in which treatment-free remission (TFR) is limited, with clinical and economic consequences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a07fbe0af7a54174df392aecf16dc75
https://pubmed.ncbi.nlm.nih.gov/30026301
https://pubmed.ncbi.nlm.nih.gov/30026301
Publikováno v:
The Journal of investigative dermatology. 137(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19928cf2598b0a2a8ed4ac08eb03a643
https://pubmed.ncbi.nlm.nih.gov/28457911
https://pubmed.ncbi.nlm.nih.gov/28457911
Publikováno v:
European journal of immunology. 46(4)
Atopic dermatitis (AD) is a chronic inflammatory disease controlled by the innate and adaptive immune system. To elucidate the impact of innate immune signaling in AD, we analyzed MyD88-deficient mice in a murine model of AD-like dermatitis by epicut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b7982a1c11cbc24eb71cc2d8b9177cb
https://pubmed.ncbi.nlm.nih.gov/26694221
https://pubmed.ncbi.nlm.nih.gov/26694221