Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Friederike Pastore"'
Autor:
Friederike Pastore, Ross L. Levine
Publikováno v:
Haematologica, Vol 101, Iss 3 (2016)
Genomic studies of hematologic malignancies have identified a spectrum of recurrent somatic alterations that contribute to acute myeloid leukemia initiation and maintenance, and which confer sensitivities to molecularly targeted therapies. The majori
Externí odkaz:
https://doaj.org/article/86474cf42258413b91e969f8b92e518e
Autor:
Hanna Janke, Friederike Pastore, Daniela Schumacher, Tobias Herold, Karl-Peter Hopfner, Stephanie Schneider, Wolfgang E Berdel, Thomas Büchner, Bernhard J Woermann, Marion Subklewe, Stefan K Bohlander, Wolfgang Hiddemann, Karsten Spiekermann, Harald Polzer
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e89560 (2014)
About 30% of patients with acute myeloid leukemia (AML) harbour mutations of the receptor tyrosine kinase FLT3, mostly internal tandem duplications (ITD) and point mutations of the second tyrosine kinase domain (TKD). It was the aim of this study to
Externí odkaz:
https://doaj.org/article/b13bc09d27824706bc8cd843182112d3
Autor:
Friederike Pastore, Philipp A Greif, Stephanie Schneider, Bianka Ksienzyk, Gudrun Mellert, Evelyn Zellmeier, Jan Braess, Cristina M Sauerland, Achim Heinecke, Utz Krug, Wolfgang E Berdel, Thomas Buechner, Bernhard Woermann, Wolfgang Hiddemann, Karsten Spiekermann
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109759 (2014)
NPM1 mutations represent frequent genetic alterations in patients with acute myeloid leukemia (AML) associated with a favorable prognosis. Different types of NPM1 mutations have been described. The purpose of our study was to evaluate the relevance o
Externí odkaz:
https://doaj.org/article/72cac2ed796c4b849ad5045a6ac22024
Autor:
Friederike Pastore, Alessandro Pastore, Georg Wittmann, Wolfgang Hiddemann, Karsten Spiekermann
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95062 (2014)
Hyperleukocytosis in AML with leukostasis is a serious life-threatening condition leading to a high early mortality which requires immediate cytoreductive therapy. Therapeutic leukapheresis is currently recommended by the American Society of Apheresi
Externí odkaz:
https://doaj.org/article/19b3eea904324856a27e3fe0c3fee926
Autor:
Ross L. Levine, Kris Vaddi, Peggy Scherle, Kristian Helin, Raajit K. Rampal, Richard P. Koche, Benjamin H. Durham, Hong Lin, Min Wang, Jaanvi Mehta, Alexander Grego, Jesper L. Maag, Stephanie Braunstein, Keith B. Cordner, Young C. Park, Anouar Zouak, Aaron D. Viny, Wenbin Xiao, Robert L. Bowman, Bing Li, Aishwarya Krishnan, Abdul Karzai, Aliaksandra Radzisheuskaya, Alessandro Pastore, Neha Bhagwat, Friederike Pastore
We investigated the role of PRMT5 in myeloproliferative neoplasm (MPN) pathogenesis and aimed to elucidate key PRMT5 targets contributing to MPN maintenance. PRMT5 is overexpressed in primary MPN cells, and PRMT5 inhibition potently reduced MPN cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e0ccf89172933899583ca064e5e694
https://doi.org/10.1158/2159-8290.c.6547909.v1
https://doi.org/10.1158/2159-8290.c.6547909.v1
Autor:
Karsten Spiekermann, Wolfgang Hiddemann, Bernhard J. Wörmann, Wolfgang E. Berdel, Dennis Görlich, Stephan Wolf, Stefan K. Bohlander, Claudia D. Baldus, Martin Neumann, Helmut Blum, Stefan Krebs, Alexander Graf, Stephanie Schneider, Nikola P. Konstandin, Bianka Ksienzyk, Evelyn Zellmeier, Kathrin Bräundl, Friederike Pastore, Daniela Schumacher, Vindi Jurinovic, Paul Kerbs, Stefanos A. Bamopoulos, Tobias Herold, Klaus H. Metzeler, Ines Hellmann, Raphael Mattes, Sophie M. Stief, Sebastian Vosberg, Luise Hartmann, Philipp A. Greif
Detailed patient characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5478c7f305bcbd911754f0f3b42245
https://doi.org/10.1158/1078-0432.22465155
https://doi.org/10.1158/1078-0432.22465155
Autor:
Karsten Spiekermann, Wolfgang Hiddemann, Bernhard J. Wörmann, Wolfgang E. Berdel, Dennis Görlich, Stephan Wolf, Stefan K. Bohlander, Claudia D. Baldus, Martin Neumann, Helmut Blum, Stefan Krebs, Alexander Graf, Stephanie Schneider, Nikola P. Konstandin, Bianka Ksienzyk, Evelyn Zellmeier, Kathrin Bräundl, Friederike Pastore, Daniela Schumacher, Vindi Jurinovic, Paul Kerbs, Stefanos A. Bamopoulos, Tobias Herold, Klaus H. Metzeler, Ines Hellmann, Raphael Mattes, Sophie M. Stief, Sebastian Vosberg, Luise Hartmann, Philipp A. Greif
Purpose: To study mechanisms of therapy resistance and disease progression, we analyzed the evolution of cytogenetically normal acute myeloid leukemia (CN-AML) based on somatic alterations.Experimental Design: We performed exome sequencing of matched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c27ebb33fe853a1cb736dcbac8401eb
https://doi.org/10.1158/1078-0432.c.6525939.v1
https://doi.org/10.1158/1078-0432.c.6525939.v1
Autor:
Friederike Pastore, Alessandro Pastore, Maja Rothenberg‐Thurley, Klaus H. Metzeler, Bianka Ksienzyk, Stephanie Schneider, Stefan K. Bohlander, Jan Braess, Maria C. Sauerland, Dennis Görlich, Wolfgang E. Berdel, Bernhard Wörmann, Michael S. von Bergwelt‐Baildon, Wolfgang Hiddemann, Karsten Spiekermann
Publikováno v:
CancerREFERENCES. 128(24)
Acute myeloid leukemia (AML) with initial hyperleukocytosis is associated with high early mortality and a poor prognosis. The aims of this study were to delineate the underlying molecular landscape in the largest cytogenetic risk group, cytogenetical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288292aadfa29d1a52b415f6b2db1b3b
https://pubmed.ncbi.nlm.nih.gov/36271776
https://pubmed.ncbi.nlm.nih.gov/36271776
Autor:
Hong Lin, Richard Koche, Stephanie Braunstein, Anouar Zouak, Bing Li, Aliaksandra Radzisheuskaya, Peggy Scherle, Min Wang, Aishwarya Krishnan, Kris Vaddi, Young C. Park, Raajit K. Rampal, Abdul Karzai, Neha Bhagwat, Benjamin H. Durham, Aaron D. Viny, Friederike Pastore, Robert L. Bowman, Alexander Grego, Wenbin Xiao, Ross L. Levine, Keith B. Cordner, Jesper L.V. Maag, Jaanvi Mehta, Kristian Helin, Alessandro Pastore
Publikováno v:
Cancer Discovery. 10:1742-1757
We investigated the role of PRMT5 in myeloproliferative neoplasm (MPN) pathogenesis and aimed to elucidate key PRMT5 targets contributing to MPN maintenance. PRMT5 is overexpressed in primary MPN cells, and PRMT5 inhibition potently reduced MPN cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::839f8fd745a9ee2e129e9b9ca7478c6d
https://doi.org/10.1158/2159-8290.cd-20-0026
https://doi.org/10.1158/2159-8290.cd-20-0026
Autor:
Tinne Verhulst, Lieven Meerpoel, Emmanuel Gustin, Weimei Sun, Matthew V. Lorenzi, Junchen Gu, Longen Zhou, Wim Bert Griet Schepens, Hillary Millar, Tongfei Wu, Viellevoye Marcel, Vineet Pande, Petra Vinken, Desiree De Lange, An Boeckx, Christopher Moy, Friederike Pastore, Geert Mannens, Sylvie Laquerre, Ulrike Philippar, Vipul Bhargava, Gaston Stanislas Marcella Diels, Thomas Nys, Kathryn Packman, Jan Willem Thuring, Erika van Heerde, Bie Verbist, Sumit Rai, Lijs Beke, Pegah Safabakhsh, Timothy A. Graubert, Yue Fan, Angelique N Gilbert, Dirk Brehmer, Vikki Keersmaekers, Barbara Morschhäuser, Danilo Fiore, David Walker, Amy J. Johnson
Publikováno v:
Molecular cancer therapeutics. 20(12)
The protein arginine methyltransferase 5 (PRMT5) methylates a variety of proteins involved in splicing, multiple signal transduction pathways, epigenetic control of gene expression, and mechanisms leading to protein expression required for cellular p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bff6d3af11d308608e3ab20a3144c14
https://pubmed.ncbi.nlm.nih.gov/34583982
https://pubmed.ncbi.nlm.nih.gov/34583982