Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Friederike Lohr"'
Autor:
Hans-Georg Häcker, Florian Grundmann, Friederike Lohr, Philipp A. Ottersbach, Jing Zhou, Gregor Schnakenburg, Michael Gütschow
Publikováno v:
Molecules, Vol 14, Iss 1, Pp 378-402 (2009)
The synthetic access to 2-sec-amino-4H-3,1-benzothiazin-4-ones 2 was explored. Compounds 2 were available from methyl 2-thioureidobenzoates 1, 2-thioureidobenzoic acids 3, and novel 2-thioureidobenzamides 6, respectively, under different conditions.
Externí odkaz:
https://doaj.org/article/187674023bee414d84531f0ad4379972
Autor:
Stefan Kehraus, Alexander Schmitz, Edith Neu, Till F. Schäberle, Stephan Felder, Thomas Höver, Friederike Lohr, Gabriele M. König
Publikováno v:
Phytochemistry Reviews. 12:507-516
In recent years the discovery of some most important antibiotic compounds obtained by fermenting environmental microbes has been reported, providing proof that isolation and fermentation of producer strains is a significant approach to decifer novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c16fec44f915963acfed308c92ab621
https://doi.org/10.1007/s11101-012-9224-x
https://doi.org/10.1007/s11101-012-9224-x
Publikováno v:
Journal of Medicinal Chemistry. 54:396-400
Using the example of cathepsin K, we demonstrate the design of highly potent and selective azadipeptide nitrile inhibitors. A systematic scan with respect to P2 and P3 substituents was carried out. Structural modifications strongly affected the enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad50669953396b29e66ee2fe8a45aae
https://doi.org/10.1021/jm101272p
https://doi.org/10.1021/jm101272p
Corallopyronin A is a promising in vivo active antibiotic, currently undergoing preclinical evaluation. This myxobacterial compound interferes with a newly identified drug target site, i.e., the switch region of the bacterial DNA-dependent RNA-polyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9ba8224733a325250b39af2a824239
https://europepmc.org/articles/PMC3910853/
https://europepmc.org/articles/PMC3910853/
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 17(41)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8832679b4effb09b388ef1cc9e341e54
https://pubmed.ncbi.nlm.nih.gov/21898616
https://pubmed.ncbi.nlm.nih.gov/21898616
Autor:
Sarah Sandmann, Yvonne Lisa Behrens, Claudia Davenport, Felicitas Thol, Michael Heuser, Daniela Dörfel, Friederike Löhr, Agnes Castrup, Doris Steinemann, Julian Varghese, Brigitte Schlegelberger, Martin Dugas, Gudrun Göhring
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Patients with myeloid neoplasia are classified by the WHO classification systems. Besides clinical and hematological criteria, cytogenetic and molecular genetic alterations highly impact treatment stratification. In routine diagnostics, a combination
Externí odkaz:
https://doaj.org/article/70d72f9689574fe49058ed0547f90185
Autor:
Cristian Gurgui, Till F. Schäberle, Friederike Lohr, Jörn Piel, Mustafa El Omari, Gabriele M. König, Shwan Rachid, Alexander Schmitz, Rolf Müller, Stefan Kehraus, Özlem Erol
Publikováno v:
Chembiochem : a European journal of chemical biology. 11(9)
Corallopyronin A is a myxobacterial compound with potent antibacterial activity. Feeding experiments with labelled precursors resulted in the deduction of all biosynthetic building blocks for corallopyronin A and revealed an unusual feature of this m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a85ee8788df3e507faf968935005d1
https://pubmed.ncbi.nlm.nih.gov/20503218
https://pubmed.ncbi.nlm.nih.gov/20503218
Autor:
Jing Zhou, Gregor Schnakenburg, Friederike Lohr, Florian Grundmann, Philipp A. Ottersbach, Hans-Georg Häcker, Michael Gütschow
Publikováno v:
Molecules; Volume 14; Issue 1; Pages: 378-402
Molecules, Vol 14, Iss 1, Pp 378-402 (2009)
Molecules
Molecules, Vol 14, Iss 1, Pp 378-402 (2009)
Molecules
The synthetic access to 2-sec-amino-4H-3,1-benzothiazin-4-ones 2 was explored. Compounds 2 were available from methyl 2-thioureidobenzoates 1, 2-thioureidobenzoic acids 3, and novel 2-thioureidobenzamides 6, respectively, under different conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b134b46da2d8e45aaacb0452c9b024cf
Publikováno v:
Natural Product Reports. 31:953
Covering: up to the end of 2013 Myxobacteria produce a vast range of structurally diverse natural products with prominent biological activities. Here, we provide a detailed description and judge the potential of all antibiotically active myxobacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32b34bf2495ee56d4cdacf6ea69f912
https://doi.org/10.1039/c4np00011k
https://doi.org/10.1039/c4np00011k
Autor:
Maxim Frizler, Pieter C. Dorrestein, Michael Gütschow, Friederike Lohr, Imke Jenniches, Gabriele M. König, Alexander Schmitz, Marc Sylvester, Michael J. Meehan, Till F. Schäberle
Publikováno v:
Chemical Science. 4:4175
In polyketide biosynthesis the reduction of β-carbonyl groups to an alkene usually results in a α,β double bond. However, in a few antibiotics the rare case of such a carbon–carbon double bond in β,γ position is observed. The in vivo active an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bafe97453989cf8237c3e151b814ff8f
https://doi.org/10.1039/c3sc51854j
https://doi.org/10.1039/c3sc51854j