Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Friederike Hans"'
Autor:
Jorge Garcia Morato, Friederike Hans, Felix von Zweydorf, Regina Feederle, Simon J. Elsässer, Angelos A. Skodras, Christian Johannes Gloeckner, Emanuele Buratti, Manuela Neumann, Philipp J. Kahle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
TDP-43 is a nucleic acid binding protein, whose insoluble aggregates are neuropathological hallmarks of specific subsets of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Post-translational modifications and acetyl
Externí odkaz:
https://doaj.org/article/5d612ba76c204e148f11afe0e162e337
Autor:
Felix Wiegand, Bianca Stöcker, Famke Bäuerle, Susanne Motameny, Andreas Buness, Alexander J. Probst, Fabian Brand, Axel Schmidt, Tyll Stöcker, Sugirthan Sivalingam, Andreas Petzold, Marc Sturm, Janine Altmueller, Johannes Köster, Kerstin Becker, Leon Brandhoff, Anna Ossowski, Christian Mertes, Avirup Guha Neogi, Gisela Gabernet, Nicholas H. Smith, Friederike Hanssen
Publikováno v:
F1000Research, Vol 12 (2024)
We present the results of the human genomic small variant calling benchmarking initiative of the German Research Foundation (DFG) funded Next Generation Sequencing Competence Network (NGS-CN) and the German Human Genome-Phenome Archive (GHGA). In thi
Externí odkaz:
https://doaj.org/article/117f3609dd9e44c58c2a7e52d9ff948e
Publikováno v:
The journal of biological chemistry 295(3), 673-689 (2019). doi:10.1074/jbc.RA119.010617
J Biol Chem
J Biol Chem
Insoluble, hyperubiquitylated TAR DNA-binding protein of 43 kDa (TDP-43) in the central nervous system characterizes frontotemporal dementia and ALS in many individuals with these neurodegenerative diseases. The causes for neuropathological TDP-43 ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeb0acdf72640fe456c545974eb3808
https://doi.org/10.1016/s0021-9258(17)49926-1
https://doi.org/10.1016/s0021-9258(17)49926-1
Autor:
Gisela Gabernet, Susanna Marquez, Robert Bjornson, Alexander Peltzer, Hailong Meng, Edel Aron, Noah Y Lee, Cole G Jensen, David Ladd, Mark Polster, Friederike Hanssen, Simon Heumos, nf-core community, Gur Yaari, Markus C Kowarik, Sven Nahnsen, Steven H Kleinstein
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012265 (2024)
Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is a valuable experimental tool to study the immune state in health and following immune challenges such as infectious diseases, (auto)immune diseases, and cancer. Several tools have been deve
Externí odkaz:
https://doaj.org/article/5c0227389c5848f6b0944bb48c78309a
Autor:
Jorge Garcia Morato, Manuela Neumann, Christian Johannes Gloeckner, Angelos Skodras, Friederike Hans, Simon J Elsaesser, Felix von Zweydorf, Emanuele Buratti, Regina Feederle, Philipp J. Kahle
Publikováno v:
Nature Communications 13(1), 1223 (2022). doi:10.1038/s41467-022-28822-7
Nat. Commun. 13:1223 (2022)
Nat. Commun. 13:1223 (2022)
The trans-activation response DNA-binding protein TDP-43 regulates RNA processing and forms neuropathological aggregates in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Investigating TDP-43 post-translational mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b746aefc39a137a222ef1f6d3b5e41
https://doi.org/10.1101/2020.05.26.104356
https://doi.org/10.1101/2020.05.26.104356
Autor:
Marita Eckert, Christian Johannes Gloeckner, Philipp J. Kahle, Friederike Hans, Felix von Zweydorf
Publikováno v:
The journal of biological chemistry 293(41), 16083-16099 (2018). doi:10.1074/jbc.RA118.003440
TAR DNA-binding protein of 43 kDa (TDP-43) forms pathological aggregates in neurodegenerative diseases, particularly in certain forms of frontotemporal dementia and amyotrophic lateral sclerosis. Pathological modifications of TDP-43 include proteolyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a852e07d31777ba0401332c782200a73
https://doi.org/10.1074/jbc.ra118.003440
https://doi.org/10.1074/jbc.ra118.003440
Autor:
Joerg B. Schulz, Philipp J. Kahle, Istvan Katona, Yasmine Wasser, Anand Goswami, Tiago F. Outeiro, Vibha Prasad, Aaron Voigt, Friederike Hans
Publikováno v:
The FASEB journal 33(2), 2116-2131 (2018). doi:10.1096/fj.201800148RRR
The pathophysiology of Parkinson's disease is characterized by the abnormal accumulation of α-synuclein (α-Syn), eventually resulting in the formation of Lewy bodies and neurites in surviving neurons in the brain. Although α-Syn aggregation has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a7b50613981fe877563d0c69c3a021
https://doi.org/10.1096/fj.201800148rrr
https://doi.org/10.1096/fj.201800148rrr
Autor:
Michael Weller, Luca Regli, Hans-Georg Rammensee, Juliane S Walz, Marian Christoph Neidert, Jens Bauer, Marcel Wacker, Gioele Medici, Marissa Dubbelaar, Annika Nelde, Friederike Hanssen, Carolin Schwitalla
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/ccd1500146f94c21beab8aa5e09abccd
Autor:
Anna Lechado Terradas, Friederike Hans, Sonia Golombek, Sven Geisler, Caren Linnemann, Etsuro Nakanishi, Lea Jäger, Nicolas Casadei, Philipp J. Kahle
Publikováno v:
Experimental cell research 384(2), 111641 (2019). doi:10.1016/j.yexcr.2019.111641
Parkin is an ubiquitin ligase regulating mitochondrial quality control reactions, including the autophagic removal of depolarized mitochondria (mitophagy). Parkin-mediated protein ubiquitinations may be counteracted by deubiquitinating enzymes (DUBs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9699e494c46184a2a3abb8b9e13a1c01
https://doi.org/10.1016/j.yexcr.2019.111641
https://doi.org/10.1016/j.yexcr.2019.111641
Autor:
Jennifer C. Strong, Wolfdieter Springer, Aaron Voigt, Jörg B. Schulz, Friederike Hans, Tobias M. Rasse, Sandra Jäckel, Sven Geisler, Philipp J. Kahle, Fabienne C. Fiesel
Publikováno v:
The journal of biological chemistry 289(27), 19164-19179 (2014). doi:10.1074/jbc.M114.561704
Trans-activation element DNA-binding protein of 43 kDa (TDP-43) characterizes insoluble protein aggregates in distinct subtypes of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. TDP-43 mediates many RNA processing steps within d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91de40a77ff473163fcbf453dc847bb