Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Frieder Kröner"'
Publikováno v:
Analytical Chemistry. 90:11240-11247
Biopharmaceuticals contain residual host cell protein (HCP) impurities, a complex mixture of endogenous proteins from production cell lines such as Chinese hamster ovary (CHO) cells. The composition of HCP impurities at harvest hinges on multiple fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b90c32fbf9d98cad90f35a73d57ad15
https://doi.org/10.1021/acs.analchem.8b01236
https://doi.org/10.1021/acs.analchem.8b01236
Publikováno v:
Journal of Chromatography A. 1318:84-91
The accelerating growth of the market for biopharmaceutical proteins, the market entry of biosimilars and the growing interest in new, more complex molecules constantly pose new challenges for bioseparation process development. In the presented work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e2f674b81eb508b7f2ea34017dcfeb
https://doi.org/10.1016/j.chroma.2013.09.043
https://doi.org/10.1016/j.chroma.2013.09.043
Autor:
Martijn W. H. Pinkse, Beckley K. Nfor, Marcel Ottens, Peter Verhaert, Alexander T. Hanke, Frieder Kröner, Jürgen Hubbuch
Publikováno v:
Journal of Chromatography A. 1311:55-64
The accelerating growth of the market for proteins and the growing interest in new, more complex molecules are bringing new challenges to the downstream process development of these proteins. This results in a demand for faster, more cost efficient,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2068e4f271f683fec0a4be3d0e75a3
https://doi.org/10.1016/j.chroma.2013.08.034
https://doi.org/10.1016/j.chroma.2013.08.034
Autor:
Jürgen Hubbuch, Frieder Kröner
Publikováno v:
Journal of chromatography. A. 1285
pH gradient protein separations are widely used techniques in the field of protein analytics, of which isoelectric focusing is the most well known application. The chromatographic variant, based on the formation of pH gradients in ion exchange column
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c8956ae5edca742b611bc24a22500d
https://pubmed.ncbi.nlm.nih.gov/23489486
https://pubmed.ncbi.nlm.nih.gov/23489486
Publikováno v:
Journal of chromatography. A. 1268
Covalent attachment of PEG to proteins, known as PEGylation, is currently one of the main approaches for improving the pharmacokinetics of biopharmaceuticals. However, the separation and characterization especially of positional isoforms of PEGylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347dca06689f59eb755e011623c89606
https://pubmed.ncbi.nlm.nih.gov/23146338
https://pubmed.ncbi.nlm.nih.gov/23146338