Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Friedemann Schmidt"'
Autor:
Yun‐Ting Chao, Freya Aden, Önder Göktas, Friedemann Schmidt, Gökhan Göktas, Miroslav Jurkov, Wolfgang Georgsdorf, Thomas Hummel
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 9, Iss 3, Pp n/a-n/a (2024)
Abstract Objectives Olfactory training (OT) has emerged as a first‐line therapeutic approach to the management of olfactory dysfunction. Conventional OT (COT) involves the systematic home‐based exposure to four distinct odors. Previous research h
Externí odkaz:
https://doaj.org/article/8eccba2ce14a414a92906cb65b98d291
Autor:
Arianna Bassan, Ronald Steigerwalt, Douglas Keller, Lisa Beilke, Paul M. Bradley, Frank Bringezu, William J. Brock, Leigh Ann Burns-Naas, Jon Chambers, Kevin Cross, Michael Dorato, Rosalie Elespuru, Douglas Fuhrer, Frances Hall, Jim Hartke, Gloria D. Jahnke, Felix M. Kluxen, Eric McDuffie, Friedemann Schmidt, Jean-Pierre Valentin, David Woolley, Doris Zane, Glenn J. Myatt
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The ICH S1B carcinogenicity global testing guideline has been recently revised with a novel addendum that describes a comprehensive integrated Weight of Evidence (WoE) approach to determine the need for a 2-year rat carcinogenicity study. In the pres
Externí odkaz:
https://doaj.org/article/3419c3b90a414f7aafa8e7a2a11aedc0
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
The preclinical identification of drug-induced cardiotoxicity and its translation into human risk are still major challenges in pharmaceutical drug discovery. The ICH S7B Guideline and Q&A on Clinical and Nonclinical Evaluation of QT/QTc Interval Pro
Externí odkaz:
https://doaj.org/article/51480fe6bfe54fbd80a1a0a0cdb1b93d
Publikováno v:
Chemical Research in Toxicology. 35:2068-2084
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e41beccaef5de6ce92b0da6740c3ec4
https://doi.org/10.1021/acs.chemrestox.2c00217
https://doi.org/10.1021/acs.chemrestox.2c00217
Autor:
Friedemann Schmidt, Christoph Grebner, Daniel Kofink, Jan Wenzel, Gerhard Hessler, Hans Matter
Publikováno v:
ChemMedChem. 16:3772-3786
In silico driven optimization of compound properties related to pharmacokinetics, pharmacodynamics, and safety is a key requirement in modern drug discovery. Nowadays, large and harmonized datasets allow to implement deep neural networks (DNNs) as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25ab258232272a991457e2f08c15f1c
https://doi.org/10.1002/cmdc.202100418
https://doi.org/10.1002/cmdc.202100418
Autor:
Nis Halland, Friedemann Schmidt, Tilo Weiss, Ziyu Li, Jörg Czech, Joachim Saas, Danping Ding-Pfennigdorff, Matthias K. Dreyer, Carsten Strübing, Marc Nazare
Publikováno v:
Journal of medicinal chemistry. 65(2)
The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. Today, no oral disease-modifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0ee7976823a8fb6cc8f2ac1ed92537
https://pubmed.ncbi.nlm.nih.gov/34931844
https://pubmed.ncbi.nlm.nih.gov/34931844
Autor:
Nicolas Tielker, Stefan M. Kast, Lukas Eberlein, Gerhard Hessler, K. Friedemann Schmidt, Stefan Güssregen
Publikováno v:
Journal of Computer-Aided Molecular Design
Joint academic–industrial projects supporting drug discovery are frequently pursued to deploy and benchmark cutting-edge methodical developments from academia in a real-world industrial environment at different scales. The dimensionality of tasks r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d46320c536f7ef239dac42093f9f0d
Autor:
Friedemann Schmidt, Stephen Jenkinson, Annie Delaunois, Lyn Rosenbrier Ribeiro, Jean-Pierre Valentin
Publikováno v:
Journal of pharmacological and toxicological methods. 105
Secondary pharmacological profiling is increasingly applied in pharmaceutical drug discovery to address unwanted pharmacological side effects of drug candidates before entering the clinic. Regulators, drug makers and patients share a demand for deep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ae8dd8879de24651beacc60fbd00b5
https://pubmed.ncbi.nlm.nih.gov/32302774
https://pubmed.ncbi.nlm.nih.gov/32302774
Autor:
Jean-Pierre Valentin, Lyn Rosenbrier-Ribeiro, Stephen Jenkinson, Jean-Michel Guillon, Sonia Roberts, Duncan Armstrong, Friedemann Schmidt, Vivek J. Kadambi, Peri Ravikumar
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:7-14
Introduction In 2015, IQ DruSafe conducted a survey of its membership to identify industry practices related to in vitro off target pharmacological profiling of small molecules. Methods An anonymous survey of 20 questions was submitted to IQ-DruSafe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a766feee1296600d39053f3d781fb9a1
https://doi.org/10.1016/j.vascn.2018.07.001
https://doi.org/10.1016/j.vascn.2018.07.001