Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Fried. J. T. Zwartkruis"'
Autor:
Antoine A. Khalil, Daan Smits, Peter D. Haughton, Thijs Koorman, Karin A. Jansen, Mathijs P. Verhagen, Mirjam van der Net, Kitty van Zwieten, Lotte Enserink, Lisa Jansen, Abdelrahman G. El-Gammal, Daan Visser, Milena Pasolli, Max Tak, Denise Westland, Paul J. van Diest, Cathy B. Moelans, M. Guy Roukens, Sandra Tavares, Anne-Marie Fortier, Morag Park, Riccardo Fodde, Martijn Gloerich, Fried. J. T. Zwartkruis, Patrick WB. Derksen, Johan de Rooij
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Dense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells (basal-like cells) maintain several epithelial characteristic
Externí odkaz:
https://doaj.org/article/50e49d8f27e74b6aa43d0874b11c6389
Autor:
Femke V. M. Mulder, Evelien F. H. I. Peeters, Jan Westerink, Fried J. T. Zwartkruis, Wendela L. de Ranitz-Greven
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-8 (2022)
Abstract Background MTOR inhibition is an effective treatment for many manifestations of tuberous sclerosis complex. Because mTOR inhibition is a disease modifying therapy, lifelong use will most likely be necessary. This study addresses the long-ter
Externí odkaz:
https://doaj.org/article/c90b1abef9fe4f0994da3c5b1a92569a
Autor:
Lucas J M Bruurs, Mirjam C van der Net, Susan Zwakenberg, Fried J T Zwartkruis, Johannes L Bos
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207159 (2018)
Apico-basal polarity establishment is a seminal process in tissue morphogenesis. To function properly it is often imperative that epithelial cells limit apical membrane formation to a single domain. We previously demonstrated that signaling by the sm
Externí odkaz:
https://doaj.org/article/9c571c6ccf794e13b859924c76a72722
Autor:
Anukrati Nigam, Deborah P. Jones, Martin Konrad, Claudia Dafinger, Karin Klingel, Stéphane Burtey, Francisco J. Arjona, David M. Sabatini, Carsten Bergmann, Eric Schulze-Bahr, Caro Bos, Pascal Houillier, Rosa Vargas-Poussou, Mehmet Eltan, Holger Thiele, Alina Braun, Tulay Guran, Nine V A M Knoers, Jeroen H. F. de Baaij, Janine Altmüller, Max C. Liebau, Karin Dahan, Nathalie Godefroid, Jun Oh, François Jouret, Holger Rehmann, Felix Kleinerüschkamp, Maria Ibars Serra, Bodo B. Beck, Bernhard Schermer, Karl P. Schlingmann, Kirsten Y. Renkema, Fried J. T. Zwartkruis, Kuang Shen, Jens König, Marie-Christine Parotte
Publikováno v:
Journal of the American Society of Nephrology, 32(11). AMER SOC NEPHROLOGY
Journal of the American Society of Nephrology, Vol. 32, no.11, p. 2885-2899 (2021)
Journal of the American Society of Nephrology, 32, 11, pp. 2885-2899
J Am Soc Nephrol
Journal of the American Society of Nephrology, 32, 2885-2899
Journal of the American Society of Nephrology, Vol. 32, no.11, p. 2885-2899 (2021)
Journal of the American Society of Nephrology, 32, 11, pp. 2885-2899
J Am Soc Nephrol
Journal of the American Society of Nephrology, 32, 2885-2899
Contains fulltext : 244896.pdf (Publisher’s version ) (Closed access) BACKGROUND: Over the last decade, advances in genetic techniques have resulted in the identification of rare hereditary disorders of renal magnesium and salt handling. Neverthele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8850e8d2efcd78ef50a2a9c7c2c8c5de
https://doi.org/10.1681/asn.2021030333
https://doi.org/10.1681/asn.2021030333
Autor:
David Chitayat, Carolina Sepulveda, Tineke Veenendaal, Grace Yoon, Cedric S. Asensio, Henny H. Lemmink, Nalan Liv, Susan Zwakenberg, Andres M. Lozano, Guy A. Caldwell, Edward F Griffin, Fried J. T. Zwartkruis, Rolph Pfundt, Reini E.N. van der Welle, Judith Klumperman, Corlinda ten Brink, Christian H. Burns, Lan Chen, Rebekah Jobling, Paolo Sanza, Susan Blaser, Teresa Santiago-Sim, Alfonso Fasano, Kim A. Caldwell, Jan van der Beek, Conny M. A. van Ravenswaaij-Arts
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp n/a-n/a (2021)
EMBO Molecular Medicine, 13
EMBO Molecular Medicine, 13, 5
EMBO Molecular Medicine, 13(5):13243, 1-24. Wiley
EMBO Molecular Medicine
EMBO Molecular Medicine, 13
EMBO Molecular Medicine, 13, 5
EMBO Molecular Medicine, 13(5):13243, 1-24. Wiley
EMBO Molecular Medicine
Vacuolar protein sorting 41 (VPS41) is as part of the Homotypic fusion and Protein Sorting (HOPS) complex required for lysosomal fusion events and, independent of HOPS, for regulated secretion. Here, we report three patients with compound heterozygou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a105fc53635f251797810bb00f87610
https://doi.org/10.15252/emmm.202013258
https://doi.org/10.15252/emmm.202013258
Autor:
Anatoly Korotkov, Fried J. T. Zwartkruis, Eleonora Aronica, Erwin A. van Vliet, Susan Zwakenberg, Floor E. Jansen, Till S. Zimmer, Nicholas Rensing, Angelika Mühlebner, James D. Mills, Michael Wong
Publikováno v:
Brain pathology (Zurich, Switzerland), 31(5):e12949. Wiley-Blackwell
Brain Pathology
Brain Pathology, 31(5):e12949. Wiley-Blackwell
Brain Pathology
Brain Pathology, 31(5):e12949. Wiley-Blackwell
Tuberous sclerosis complex (TSC) is a congenital disorder characterized by cortical malformations and concomitant epilepsy caused by loss‐of‐function mutations in the mTOR suppressors TSC1 or TSC2. While the underlying molecular changes caused by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979ce8f2f639c0d5b0b3250dc461db46
https://pure.amc.nl/en/publications/upregulation-of-the-pathogenic-transcription-factor-spi1pu1-in-tuberous-sclerosis-complex-and-focal-cortical-dysplasia-by-oxidative-stress(e7f86fa1-1b7e-466e-8925-c736f6c02dae).html
https://pure.amc.nl/en/publications/upregulation-of-the-pathogenic-transcription-factor-spi1pu1-in-tuberous-sclerosis-complex-and-focal-cortical-dysplasia-by-oxidative-stress(e7f86fa1-1b7e-466e-8925-c736f6c02dae).html
Autor:
Angela Ho, Boudewijn M.T. Burgering, Ingrid F. Kjønstad, Niels Eijkelkamp, Fried J. T. Zwartkruis, Pål Ø. Falnes, Jędrzej Małecki, Anders Moen, Rita Pinto, Hanneke L.D.M. Willemen
Publikováno v:
Journal of Biological Chemistry. 294:1128-1141
Lysine methylation is an important post-translational modification that is also present on mitochondrial proteins, but the mitochondrial lysine-specific methyltransferases (KMTs) responsible for modification are in most cases unknown. Here, we set ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11f01063764b271a87663f86709cae5
https://doi.org/10.1074/jbc.ra118.005473
https://doi.org/10.1074/jbc.ra118.005473
Autor:
Sepide Derakhshan, Saskia E. van Mil, Arjan C. Houweling, Puck Veen, Irma van de Beek, Iris E. Glykofridis, Jaco C. Knol, Jesper A. Balk, Rob M. F. Wolthuis, Thang V. Pham, Martin A. Rooimans, Pino J Poddighe, Jarno Drost, Franziska Böttger, Sander R. Piersma, Fried J. T. Zwartkruis, Denise Westland, Sinéad M. Lougheed, Hanne Meijers-Heijboer, Renee X. de Menezes, Connie R. Jimenez
Publikováno v:
eLife, Vol 10 (2021)
Glykofridis, I E, Knol, J C, Balk, J A, Westland, D, Pham, T V, Piersma, S R, Lougheed, S M, Derakhshan, S, Veen, P, Rooimans, M A, van Mil, S E, Böttger, F, Poddighe, P J, van de Beek, I, Drost, J, Zwartkruis, F J T, de Menezes, R X, Meijers-Heijboer, H E J, Houweling, A C, Jimenez, C R & Wolthuis, R M F 2021, ' Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells ', eLife, vol. 10, e61630, pp. 1-71 . https://doi.org/10.7554/eLife.61630
eLife, 10:e61630, 1-71. eLife Sciences Publications Limited
eLife
eLife, 10:e61630, 1-71. eLife Sciences Publications
Glykofridis, I E, Knol, J C, Balk, J A, Westland, D, Pham, T V, Piersma, S R, Lougheed, S M, Derakhshan, S, Veen, P, Rooimans, M A, van Mil, S E, Böttger, F, Poddighe, P J, van de Beek, I, Drost, J, Zwartkruis, F J T, de Menezes, R X, Meijers-Heijboer, H E J, Houweling, A C, Jimenez, C R & Wolthuis, R M F 2021, ' Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells ', eLife, vol. 10, e61630, pp. 1-71 . https://doi.org/10.7554/eLife.61630
eLife, 10:e61630, 1-71. eLife Sciences Publications Limited
eLife
eLife, 10:e61630, 1-71. eLife Sciences Publications
Germline mutations in the Folliculin (FLCN) tumor suppressor gene cause Birt–Hogg–Dubé (BHD) syndrome, a rare autosomal dominant disorder predisposing carriers to kidney tumors.FLCNis a conserved, essential gene linked to diverse cellular proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c318dc7a734f524573728d55ffea5d63
https://elifesciences.org/articles/61630
https://elifesciences.org/articles/61630
Autor:
Marlous J Groenewoud, Susan M I Goorden, Jorien Kassies, Wendy Pellis-van Berkel, Richard F Lamb, Ype Elgersma, Fried J T Zwartkruis
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81649 (2013)
The Ras-like GTPase Rheb has been identified as a crucial activator of mTORC1. Activation most likely requires a direct interaction between Rheb and mTOR, but the exact mechanism remains unclear. Using a panel of Rheb-deficient mouse embryonic fibrob
Externí odkaz:
https://doaj.org/article/edc64efd4a3e423a8d0aa5f31ad68ab3
Publikováno v:
Open Biology, Vol 3, Iss 12 (2013)
Mitochondrial dysfunction has been associated with various diseases, such as cancer, myopathies, neurodegeneration and obesity. Mitochondrial homoeostasis is achieved by mechanisms that adapt the number of mitochondria to that required for energy pro
Externí odkaz:
https://doaj.org/article/ad07515f7c7246b685cf512a1234a562