A Retrospective Analysis of Preclinical and Clinical Pharmacokinetics from Administration of Long-Acting Aqueous Suspensions

Autor: Ashley R. Johnson, Jeanine E. Ballard, Andrew Leithead, Corin Miller, Fried Faassen, Xiaowei Zang, Rebecca Nofsinger, Angela M. Wagner

Publikováno v: Pharmaceutical Research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fa4f0d19d8aa16c51e757827bbc867c
https://doi.org/10.1007/s11095-023-03470-8

Milling of Organic Solids in a Jet Mill. Part 1: Determination of the Selection Function and Related Mechanical Material Properties

Autor: O de Vegt, Kees van der Voort Maarschalk, Fried Faassen, Herman Vromans

Publikováno v: Part.Part.Syst.Charact., 22(2), 133-140. WILEY-V C H VERLAG GMBH

The particle size distribution of pharmaceutically active materials and other fine chemicals determines the performance of the final product to a large extent. Often milling of these particles is necessary. It is not possible to determine the milling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1ff65f8f7461559009e2328b7e4594
https://doi.org/10.1002/ppsc.200400969

Lymphatic transport of Methylnortestosterone undecanoate (MU) and the bioavailability of methylnortestosterone are highly sensitive to the mass of coadministered lipid after oral administration of MU

Autor: Glenn A. Edwards, Christopher J.H. Porter, Karen L. White, W A (Fried) Faassen, William N. Charman, Gary Nguyen

Publikováno v: The Journal of pharmacology and experimental therapeutics. 331(2)

The contribution of lymphatic transport to the oral bioavailability of methylnortestosterone (M) after oral administration of the lipophilic prodrug methylnortestosterone undecanoate (MU) has been evaluated, and the sensitivity of lymphatic MU transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41ad71d990a61cb6b0b9b5e4e9ec198
https://pubmed.ncbi.nlm.nih.gov/19696095

Milling of organic solids in a jet mill. Part 2: Checking the validity of the predicted rate of breakage function

Autor: van der Kees Voort Maarschalk, Fried Faassen, Herman Vromans, O de Vegt

Publikováno v: Part.Part.Syst.Charact., 22, 261-267. WILEY-V C H VERLAG GMBH
Particle & Particle Systems Characterization, 22(4), 261-267. WILEY-V C H VERLAG GMBH

The particle size distribution of fine chemicals in the solid state, like active pharmaceutical ingredients, is often a critical parameter. To achieve the desired particle size distribution, milling of such materials is usually the method of choice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bdf40fc3c088007967f2be3d0fd74b
https://research.rug.nl/en/publications/36c92696-7162-4cc1-a245-294ad28cd16e

Milling of agglomerates in an impact mill

Autor: Joost J.A.M. Verheezen, Kees van der Voort Maarschalk, Fried Faassen, Herman Vromans

Publikováno v: International journal of pharmaceutics. 278(1)

Milling of agglomerates is one of the common unit operations during preparation of oral dosage forms like capsules and tablets. In literature the breakage of granules is mostly determined after single impact at an ideally formed granule or of single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48bb0606796f6d175e34ad656174fb5
https://pubmed.ncbi.nlm.nih.gov/15158958