Direct effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses

Autor: Sangeetha Ramu, Hamid Akbarshahi, Sofia Mogren, Frida Berlin, Samuel Cerps, Mandy Menzel, Morten Hvidtfeldt, Celeste Porsbjerg, Lena Uller, Cecilia K. Andersson

Publikováno v: BMC Immunology, Vol 22, Iss 1, Pp 1-12 (2021)

Abstract Background Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggested to play a role in t

Externí odkaz: https://doaj.org/article/abc116dee2964053bb80f7192e788dae

Mast Cell Tryptase Promotes Airway Remodeling by Inducing Anti-Apoptotic and Cell Growth Properties in Human Alveolar and Bronchial Epithelial Cells

Autor: Frida Berlin, Sofia Mogren, Camilla Ly, Sangeetha Ramu, Morten Hvidtfeldt, Lena Uller, Celeste Porsbjerg, Cecilia K. Andersson

Publikováno v: Cells, Vol 12, Iss 10, p 1439 (2023)

Bronchial and alveolar remodeling and impaired epithelial function are characteristics of chronic respiratory diseases. In these patients, an increased number of mast cells (MCs) positive for serine proteases, tryptase and chymase, infiltrate the epi

Externí odkaz: https://doaj.org/article/446aa61587d04f7eb9e80020ecb71d2f

Mast Cell Proteases Promote Diverse Effects on the Plasminogen Activation System and Wound Healing in A549 Alveolar Epithelial Cells

Autor: Sofia Mogren, Frida Berlin, Lykke Eskilsson, Nicole Van Der Burg, Ellen Tufvesson, Cecilia K. Andersson

Publikováno v: Cells, Vol 11, Iss 18, p 2916 (2022)

Tissue damage, epithelial alterations, and intraepithelial presence of mast cells (MCs) are characteristics of asthma pathogenesis. Increased alveolar infiltration of MC populations has also been identified as a feature of asthma and other chronic re

Externí odkaz: https://doaj.org/article/b0f66339118140e591d3838bdd26deb4

Mast Cell Proteases Promote Diverse Effects on the Plasminogen Activation System and Wound Healing in A549 Alveolar Epithelial Cells

Autor: Andersson, Sofia Mogren, Frida Berlin, Lykke Eskilsson, Nicole Van Der Burg, Ellen Tufvesson, Cecilia K.

Publikováno v: Cells; Volume 11; Issue 18; Pages: 2916

Tissue damage, epithelial alterations, and intraepithelial presence of mast cells (MCs) are characteristics of asthma pathogenesis. Increased alveolar infiltration of MC populations has also been identified as a feature of asthma and other chronic re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::8074c0236b8f7ab4239020d52fa8e40a

Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells

Autor: Frida Berlin, Sangeetha Ramu, Celeste Porsbjerg, Asger Sverrild, Sofia Mogren, Lena Uller, Cecilia Andersson

Publikováno v: Mogren, S, Berlin, F, Ramu, S, Sverrild, A, Porsbjerg, C, Uller, L & Andersson, C K 2021, ' Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells ', Cell Adhesion and Migration, vol. 15, no. 1, pp. 202-214 . https://doi.org/10.1080/19336918.2021.1950594
Cell Adhesion & Migration
article-version (VoR) Version of Record
Cell Adhesion & Migration, Vol 15, Iss 1, Pp 202-214 (2021)

Epithelial damage and increase of intraepithelial mast cells (MC) are characteristics of asthma. The role of MC mediator tryptase and the protease-activated receptor-2 (PAR2) on epithelial wound healing is not fully investigated. Stimulation of bronc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5230ba8a5401cfda739c833e1d5f62
https://doi.org/10.1080/19336918.2021.1950594