Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Frida, Belinky"'
Autor:
Sung Hee Ko, Pierce Radecki, Frida Belinky, Jinal N. Bhiman, Susan Meiring, Jackie Kleynhans, Daniel Amoako, Vanessa Guerra Canedo, Margaret Lucas, Dikeledi Kekana, Neil Martinson, Limakatso Lebina, Josie Everatt, Stefano Tempia, Tatsiana Bylund, Reda Rawi, Peter D. Kwong, Nicole Wolter, Anne von Gottberg, Cheryl Cohen, Eli A. Boritz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Previous studies have linked the evolution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic variants to persistent infections in people with immunocompromising conditions, but the processes responsible for these observ
Externí odkaz:
https://doaj.org/article/4c104c43f256465086f7fc4adab1a576
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Nucleotide substitutions in protein-coding genes can be divided into synonymous (S) and non-synonymous (N) ones that alter amino acids (including nonsense mutations causing stop codons). The S substitutions are expected to have little effect on funct
Externí odkaz:
https://doaj.org/article/5fc803d1c2a44897b932ad76de7fa064
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background Single nucleotide substitutions in protein-coding genes can be divided into synonymous (S), with little fitness effect, and non-synonymous (N) ones that alter amino acids and thus generally have a greater effect. Most of the N sub
Externí odkaz:
https://doaj.org/article/e8fb619a68ed46128a22374be062099d
Autor:
Noa Rappaport, Simon Fishilevich, Ron Nudel, Michal Twik, Frida Belinky, Inbar Plaschkes, Tsippi Iny Stein, Dana Cohen, Danit Oz-Levi, Marilyn Safran, Doron Lancet
Publikováno v:
BioMedical Engineering OnLine, Vol 16, Iss S1, Pp 1-14 (2017)
Abstract Background A key challenge in the realm of human disease research is next generation sequencing (NGS) interpretation, whereby identified filtered variant-harboring genes are associated with a patient’s disease phenotypes. This necessitates
Externí odkaz:
https://doaj.org/article/fde3297c5a974cf4b96c55ac194f83d5
Analysis of Stop Codons within Prokaryotic Protein-Coding Genes Suggests Frequent Readthrough Events
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1876 (2021)
Nonsense mutations turn a coding (sense) codon into an in-frame stop codon that is assumed to result in a truncated protein product. Thus, nonsense substitutions are the hallmark of pseudogenes and are used to identify them. Here we show that in-fram
Externí odkaz:
https://doaj.org/article/355ee57a9b6a4fb8a917c555967362a8
Autor:
Igor B. Rogozin, Abiel Roche-Lima, Artem G. Lada, Frida Belinky, Ivan A. Sidorenko, Galina V. Glazko, Vladimir N. Babenko, David N. Cooper, Youri I. Pavlov
Publikováno v:
Cancers, Vol 11, Iss 2, p 211 (2019)
Cancer genomes accumulate nucleotide sequence variations that number in the tens of thousands per genome. A prominent fraction of these mutations is thought to arise as a consequence of the off-target activity of DNA/RNA editing cytosine deaminases.
Externí odkaz:
https://doaj.org/article/f25e3217b9304d919e053bccda95d2ce
Autor:
Gabriel Matos-Rodrigues, Niek van Wietmarschen, Wei Wu, Veenu Tripathi, Natasha Koussa, Raphael Pavani, William Nathan, Frida Belinky, Ashraf Mohammed, Marek Napierala, Karen Usdin, Aseem Z. Ansari, Sergei M. Mirkin, André Nussenzweig
SummaryGenomic double-stranded DNA (dsDNA) becomes single-stranded (ssDNA) during replication, transcription, and DNA repair. ssDNA is therefore believed to be transient, occurring in only a fraction of the genome at a given time, and variable amongs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d394f2929754d67eefbe2050b9f1e35
https://doi.org/10.1101/2022.01.19.476973
https://doi.org/10.1101/2022.01.19.476973
Autor:
Sydney R, Stein, Sabrina C, Ramelli, Alison, Grazioli, Joon-Yong, Chung, Manmeet, Singh, Claude Kwe, Yinda, Clayton W, Winkler, Junfeng, Sun, James M, Dickey, Kris, Ylaya, Sung Hee, Ko, Andrew P, Platt, Peter D, Burbelo, Martha, Quezado, Stefania, Pittaluga, Madeleine, Purcell, Vincent J, Munster, Frida, Belinky, Marcos J, Ramos-Benitez, Eli A, Boritz, Izabella A, Lach, Daniel L, Herr, Joseph, Rabin, Kapil K, Saharia, Ronson J, Madathil, Ali, Tabatabai, Shahabuddin, Soherwardi, Michael T, McCurdy, Karin E, Peterson, Jeffrey I, Cohen, Emmie, de Wit, Kevin M, Vannella, Stephen M, Hewitt, David E, Kleiner, Phuoc, Pham
Publikováno v:
Nature. 612(7941)
Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction
Autor:
Gabriel Matos-Rodrigues, Niek van Wietmarschen, Wei Wu, Veenu Tripathi, Natasha C. Koussa, Raphael Pavani, William J. Nathan, Elsa Callen, Frida Belinky, Ashraf Mohammed, Marek Napierala, Karen Usdin, Aseem Z. Ansari, Sergei M. Mirkin, André Nussenzweig
Publikováno v:
Molecular Cell. 82:3538-3552.e5
DNA becomes single stranded (ssDNA) during replication, transcription, and repair. Transiently formed ssDNA segments can adopt alternative conformations, including cruciforms, triplexes, and quadruplexes. To determine whether there are stable regions
Autor:
Momoko Ishikawa, André Nussenzweig, Peter J. McKinnon, Michelle E. Ehrlich, Andre Stanlie, Nancy Wong, Wei Wu, Frida Belinky, Dali Zong, Kenta Shinoda, Lavinia C. Dumitrache, Elsa Callen
The Shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and REV7, shields DNA double strand breaks (DSBs) from nucleolytic resection. The end-protecting activity of Shieldin promotes productive non-homologous end joining (NHEJ) in G1 but can threaten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a392b928dbc5ee9661a5b3c17a52908
https://doi.org/10.1101/2020.07.19.210773
https://doi.org/10.1101/2020.07.19.210773