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pro vyhledávání: '"Freya M. Bull"'
Autor:
Christine L. Willis, Jonathan A. Davies, Freya M. Bull, Joleen Masschelein, Angus N M Weir, Thomas J. Simpson, Matthew P. Crump, Paul D. Walker, Rob Lavigne, Paul R. Race
Publikováno v:
Davies, J A, Bull, F M, Walker, P D, Weir, A N M, Lavigne, R, Masschelein, J, Simpson, T J, Race, P R, Crump, M P & Willis, C L 2020, ' Total Synthesis of Kalimantacin A ', Organic Letters, vol. 22, no. 16, pp. 6349-6353 . https://doi.org/10.1021/acs.orglett.0c02190
The kalimantacins make up a family of hybrid polyketide-nonribosomal peptide-derived natural products that display potent and selective antibiotic activity against multidrug resistant strains of Staphylococcus aureus. Herein, we report the first tota
Autor:
Matthew P. Crump, Zhongshu Song, Paul R. Race, Freya M. Bull, Joleen Masschelein, Luoyi Wang, Chengsen Cui, Thomas J. Simpson, Rob Lavigne, Shu-Shan Gao, Iain R. G. Thistlethwaite, Paul D. Walker, Christine L. Willis
Publikováno v:
Thistlethwaite, I, Bull, F, Cui, C, Walker, P, Gao, S-S, Wang, L, Song, Z, Masschelein, J, Lavigne, R, Crump, M, Race, P, Simpson, T & Willis, C 2017, ' Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics ', Chemical Science, vol. 8, no. 9, pp. 6196-6201 . https://doi.org/10.1039/c7sc01670k
Kalimantacin A and batumin exhibit potent and selective antibiotic activity against Staphylococcus species including MRSA. Both compounds are formed via a hybrid polyketide synthase/non-ribosomal peptide synthetase (PKS-NRPS) biosynthetic pathway and