Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Freya Gehling"'
Autor:
Leila Belle, Gregory J. Goodall, Xiaochun Li, Nicole L. Schieber, Elizabeth V. Nguyen, Freya Gehling, Ana Lonic, Yeesim Khew-Goodall, Roger J. Daly, Robert G. Parton
Publikováno v:
The Journal of Cell Biology
Lonic et al. show that phosphorylation of Y374-PKCδ by FER arrests the maturation of early to late endosomes by inhibiting the release of RAB5 from nascent late endosomes. This promotes EGFR recycling and sustained signaling in triple-negative breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3921a5258e15c853b447ad44aad013a
https://doi.org/10.1083/jcb.201902073
https://doi.org/10.1083/jcb.201902073
Autor:
David Francis, David E. Godler, Danuta Z. Loesch, David J. Amor, Glynda J. Kinsella, John L. Hopper, Elsdon Storey, Michele Y. Ono, Freya Gehling, Yoshimi Inaba, Howard R. Slater, Randi J Hagerman, Quang M. Bui
Publikováno v:
Clinical Chemistry. 58:590-598
BACKGROUND Cognitive status in females with mutations in the FMR1 (fragile X mental retardation 1) gene is highly variable. A biomarker would be of value for predicting which individuals were liable to develop cognitive impairment and could benefit f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc538c4356a6e1d8054e71b9b1fe6277
https://doi.org/10.1373/clinchem.2011.177626
https://doi.org/10.1373/clinchem.2011.177626
Autor:
Randi J Hagerman, Quang M. Bui, Danuta Z. Loesch, Michele Ono, Freya Gehling, David J. Amor, John L. Hopper, David Francis, David E. Godler, Howard R. Slater
Publikováno v:
The Journal of Molecular Diagnostics. 13:528-536
Fragile X syndrome (FXS) is caused by loss of the fragile X mental retardation gene protein product (FMRP) through promoter hypermethylation, which is usually associated with CGG expansion to full mutation size (>200 CGG repeats). Methylation-sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf61571ee887372348a25a41913205e5
https://doi.org/10.1016/j.jmoldx.2011.05.006
https://doi.org/10.1016/j.jmoldx.2011.05.006
Autor:
Quang M. Bui, Elsdon Storey, Glynda J. Kinsella, Nicholas Trost, David E. Godler, Freya Gehling, Alison Venn, Katya Kotschet, David R. Thorburn, Howard R. Slater, Andrew Evans, David Francis, Paige Stimpson, Danuta Z. Loesch, Malcolm K. Horne
Publikováno v:
Genetics in Medicine. 13:392-399
Purpose: Our previous results showed that both gray zone and lower end premutation range (40-85 repeats) fragile X mental retardation 1(FMR1) alleles were more common among males with parkinsonism than in the general population. This study aimed to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5329b31e7ea5eb42e7c81e8188f8ae6
https://doi.org/10.1097/gim.0b013e3182064362
https://doi.org/10.1097/gim.0b013e3182064362
Autor:
Emma Gould, Cheryl Dissanayake, Howard R. Slater, David E. Godler, Trent Burgess, Mahmoud Shekari Khaniani, Freya Gehling, K. H. Andy Choo, Flora Tassone, Richard Huggins, Danuta Z. Loesch
Publikováno v:
American Journal of Medical Genetics Part A. :2306-2310
Three allelic classes of expanded CGG trinucleotide repeat in the fragile X mental retardation 1 (FMR1) gene have been recognized. The full mutation, FM (>200 repeats), which causes a Fragile X syndrome, is normally associated with epigenetic silenci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26f76bbaecbd7b3763ff787fdb01881
https://doi.org/10.1002/ajmg.a.32990
https://doi.org/10.1002/ajmg.a.32990
Autor:
Suraya Roslan, Roger J. Daly, Leila Belle, Paul Timpson, James R.W. Conway, Gelareh Farshid, Gregory J. Goodall, Freya Gehling, Yeesim Khew-Goodall, Xiaochun Li, Lesley A. Crocker, Naveid A. Ali, Anna Tsykin, David Herrmann, Andrew G. Bert, James L. Paltridge, Ana Lonic
Publikováno v:
Science signaling. 8(364)
Factors secreted by tumor cells shape the local microenvironment to promote invasion and metastasis, as well as condition the premetastatic niche to enable secondary-site colonization and growth. In addition to this secretome, tumor cells have increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12375e35741d599b1cbed58ee8f9e54
https://pubmed.ncbi.nlm.nih.gov/25690013
https://pubmed.ncbi.nlm.nih.gov/25690013
Autor:
Randi J Hagerman, K.H. Choo, Devika Ganesamoorthy, Howard R. Slater, Freya Gehling, Lavinia Gordon, Flora Tassone, Danuta Z. Loesch, Debbie Hennerich, Trent Burgess, Annette K. Taylor, Andrew Evans, David E. Godler
Publikováno v:
Human molecular genetics. 19(8)
The fragile X syndrome (FXS) is caused by silencing of the fragile X mental retardation gene (FMR1) and the absence of its product, fragile X mental retardation protein (FMRP), resulting from CpG island methylation associated with large CGG repeat ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df2104efdc33f55945aff158f396859
https://pubmed.ncbi.nlm.nih.gov/20118148
https://pubmed.ncbi.nlm.nih.gov/20118148