Výsledky vyhledávání - "Freya Freyre"

Akademický článek

Transgenic plants of Nicotiana tabacum L. express aglycosylated monoclonal antibody with antitumor activity

Autor: Meilyn Rodríguez, Merardo Pujol, Lincidio Pérez, Jorge V Gavilondo, Greta Garrido, Marta Ayala, Marlene Pérez, Mónica Bequet-Romero, Gleysin Cabrera, Osmani Ramos, Ignacio Hernández, Ernesto M González, Vivian Huerta, Belinda Sánchez, Cristina Mateo, Ada Triguero, Osmani Mendoza, Freya Freyre, Carlos Borroto

Publikováno v: Biotecnología Aplicada, Vol 30, Iss 2, Pp 157-161

The expression and production of pharmaceutical, industrial and veterinary proteins in plants is an attractive approach. These expression hosts bear an enormous production potential in terms of volume, easy processing of the starting material, and sa

Externí odkaz: https://doaj.org/article/9ac0371e2fdb46b089e230659c47c3ac

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An in house qPCR System to Evaluate Transcripts Stimulated by an Immune Innate Agonist (CIGB2020) during the Covid19 Pandemic Scenario

Autor: Jorge Aguiar, José Angel Silva, Omar Gel, Regla Estrada, Freya Freyre, Chabeli Rodríguez, Eduardo Pentón, Gerardo Guillén, Julio Cesar Aguilar

Publikováno v: Applied Cell Biology. 10

Background: A low cost and simple real-time PCR method to quantify different transcripts in human samples is a need in most developing countries. A quantitative real-time PCR assay to evaluate the relative RNA expression stimulation of specific trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41fedfd80c6716599e9057d4167dc7e1
https://doi.org/10.53043/2320-1991.acb90024

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Five-year Follow-up of Chronic Hepatitis B Patients Immunized by Nasal Route with the Therapeutic Vaccine HeberNasvac

Autor: Pablo Díaz, Julio C Aguilar, Arístides Aguilar, Jorge Aguiar, Eduardo Pentón, Guillermo Fernández, Nelvis Figueroa, Zurina Cinza, Yamila Leon, Verena Muzio, Gerardo G Nieto, Luis E Anillo, Freya Freyre, Ana Lidia Sánchez, Yadira Lobaina, Everardo Jerez

Publikováno v: Euroasian Journal of Hepato-Gastroenterology

A novel therapeutic vaccine for chronic hepatitis B (CHB) treatment comprising the recombinant hepatitis B surface (HBsAg) and nucleocapsid (HBcAg) antigens has been developed. Preclinical and clinical trials (CT) evidenced safety and immunogenicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742063da601f9fa327d2439941b1691a
https://pubmed.ncbi.nlm.nih.gov/30828555

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Optimization of a Therapeutic Vaccine Candidate by Studying Routes, Immunization Schedules and Antigen Doses in HBsAg-positive Transgenic Mice

Autor: Heidy Trujillo, Daymir García, Jorge Aguiar, Julio C Aguilar, Freya Freyre, Aracelys Blanco, Yadira Lobaina

Publikováno v: Euroasian Journal of Hepato-Gastroenterology

Hepatitis B core antigens (HBcAg) and hepatitis B surface antigens (HBsAg) are the main structural antigens of hepatitis B virus (HBV). Both antigens are potent immunogens for experimental animals as well as in acutely infected patients. A novel form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2945298b5b5cc3bfa7814152924bb824
https://doi.org/10.5005/jp-journals-10018-1105

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Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds

Autor: María Eugenia Triana, Freya Freyre, Jose F. Montequin, Nelson Merino, Ana María Quintela, Isabel Guillén, Danay Cibrian, Dioslaida Urquiza, Paul J. Thornalley, José Suárez Alba, Alfredo Aldama, Jorge Berlanga, Naila Ahmed, Pedro Lopez-Saura, Hussam H. Ajamieh

Publikováno v: Clinical Science. 109:83-95

Increased formation of MG (methylglyoxal) and related protein glycation in diabetes has been linked to the development of diabetic vascular complications. Diabetes is also associated with impaired wound healing. In the present study, we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39e135add91ebd7d5776d858e2eaf99
https://doi.org/10.1042/cs20050026

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High cytoplasmic expression in E. coli, purification, and in vitro refolding of a single chain Fv antibody fragment against the hepatitis B surface antigen

Autor: Viviana Falcón, Freya Freyre, Hansell Bell, Idolka Pedroso, Jorge V. Gavilondo, Leticia Sánchez, Marta Ayala

Publikováno v: Journal of Biotechnology. 72:13-20

A single-chain Fv (scFv) antibody fragment against the hepatitis B surface antigen (HBsAg) was expressed in Escherichia coli in the form of two independent fusion proteins, with either 60 (‘long’) or 27 (‘short’) amino acid N-terminal encodin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc86951235988437e4c205e6aa98e95d
https://doi.org/10.1016/s0168-1656(99)00036-x

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Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure

Autor: Gerardo Guillén, Raymond J. Playford, Micheal J.-T. Kim, Robert A. Goodlad, Hussam H. Ajamieh, Olga Sonia León, Subrata Ghosh, Tania Marchbank, Jorge Berlanga, José Suárez Alba, Danay Cibrian, Freya Freyre, Joseph J. Boyle, Pedro Lopez-Saura, Diana García del Barco

Publikováno v: Clinical science (London, England : 1979). 110(5)

Novel therapies for the treatment of MOF (multiple organ failure) are required. In the present study, we examined the effect of synthetic GHRP-6 (growth hormone-releasing peptide-6) on cell migration and proliferation using rat intestinal epithelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c737819cb9b9b8acab22a637bff13aa1
https://pubmed.ncbi.nlm.nih.gov/16417467

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Transient expression in tobacco leaves of an aglycosylated recombinant antibody against the epidermal growth factor receptor

Autor: Meilyn, Rodríguez, Nadia I, Ramírez, Marta, Ayala, Freya, Freyre, Lincidio, Pérez, Ada, Triguero, Cristina, Mateo, Guillermo, Selman-Housein, Jorge V, Gavilondo, Merardo, Pujol

Publikováno v: Biotechnology and bioengineering. 89(2)

When generating stably transformed transgenic plants, transient gene expression experiments are especially useful to rapidly confirm that the foreign molecule of interest is correctly assembled and retains its biological activity. TheraCIM(R) (CIMAB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::528cceba3f170595e0c213a2dffde3d6
https://pubmed.ncbi.nlm.nih.gov/15584026

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Hexa-histidine tag as a novel alternative for one-step direct labelling of a single-chain Fv antibody fragment with 99m Tc

Autor: Y Felipe, C Carderón, W Quesada, J V Gavilondo, G. Pimentel, Freya Freyre, J E Vázquez, J P Oliva

Publikováno v: Nuclear medicine communications. 22(10)

From genetic material of hybridoma cells, we have generated a recombinant single-chain antibody fragment (scFv antibody) specific to carcinoembryonic antigen (CEA), which can substitute an intact murine monoclonal immunoglobulin G1 (IgG1) antibody, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a2fde3975c510b90d9341897d1102f
https://pubmed.ncbi.nlm.nih.gov/11567181

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