Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Frenel Fils Demorin"'
Autor:
Qingyian Liu, Kaustav Biswas, Frank Koegler, Tiffany L. Correll, Toni Williamson, Jodi Bradley, Jennifer R. Allen, Leeanne Zalameda, Darren L. Reid, Michael D. Bartberger, Joe Zhu, Stephen J. Wood, Randy Hungate, Yichin Liu, Frank Chavez, Robert M. Rzasa, Jianhua Zhang, John D. McCarter, Thomas Nixey, Paul H. Wen, Li Zhu, Shannon Rumfelt, Yi Luo, Safura Babu-Khan, Stephen Hitchcock, Ning Chen, Mqhele Ncube, Wenyuan Qian, Frenel Fils Demorin, Dean Hickman, Christopher M. Tegley, Jian J. Chen, Albert Amegadzie, Charles W. Dean, Chester Chenguang Yuan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6447-6454
γ-Secretase modulators (GSMs) are potentially disease-modifying treatments for Alzheimer's disease. They selectively lower pathogenic Aβ42 levels by shifting the enzyme cleavage sites without inhibiting γ-secretase activity, possibly avoiding know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9717b5fcc1d773beec78fba83ce7ef
https://doi.org/10.1016/j.bmcl.2013.09.041
https://doi.org/10.1016/j.bmcl.2013.09.041
Autor:
Linda F. Epstein, Josette Carnahan, Manory Fernando, Douglas A. Whittington, Jeffrey Petkus, Joseph L. Kim, Matthew R. Lee, Adrian L. Smith, Nick A. Paras, Qi Huang, Pedro J. Beltran, Elizabeth M. Doherty, Thomas Nixey, Quynh Le, Mark J. Rose, Frenel Fils Demorin, Kristen Hess, Carol Babij
Publikováno v:
Journal of Medicinal Chemistry. 52:6189-6192
The discovery and optimization of a novel series of aminoisoquinolines as potent, selective, and efficacious inhibitors of the mutant B-Raf pathway is presented. The N-linked pyridylpyrimidine benzamide 2 was identified as a potent, modestly selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ed3cac42b07e4ebb0ebcf1afc3e1c1
https://doi.org/10.1021/jm901081g
https://doi.org/10.1021/jm901081g
Autor:
Berger Dan Maarten, Minu Dutia, Gary Harold Birnberg, Frenel Fils Demorin, Yanong D. Wang, Dennis Powell
Publikováno v:
Synthesis. 2003:1712-1716
The regioselective synthesis of compound 3, a potent Src kinase inhibitor is described. A key step in this synthesis is the regioselective thermal rearrangement of a substituted benzocyclobutene to provide a 2,3,6,7-tetrasubstituted naphthalene. An e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e028bdafc16abeb21ed9d5dffc4ec34c
https://doi.org/10.1055/s-2003-40872
https://doi.org/10.1055/s-2003-40872
Autor:
Dennis Powell, Minu Dutia, Berger Dan Maarten, Frenel Fils Demorin, Jennifer Weber, Yuri Raifeld, Allan Wissner, Frank Boschelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2989-2992
A series of substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles has been prepared as Src kinase inhibitors. Optimal activity is observed with compounds that have basic amines attached via the para position of the 7-phenyl ring, and a hydrogen ato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d64d2b2961df7d8d53021c60efe9f7c
https://doi.org/10.1016/s0960-894x(02)00577-2
https://doi.org/10.1016/s0960-894x(02)00577-2
Autor:
Gary Harold Birnberg, Frenel Fils Demorin, Berger Dan Maarten, Yanong D. Wang, Minu Dutia, Dennis Powell
Publikováno v:
ChemInform. 34
The regioselective synthesis of compound 3, a potent Src kinase inhibitor is described. A key step in this synthesis is the regioselective thermal rearrangement of a substituted benzocyclobutene to provide a 2,3,6,7-tetrasubstituted naphthalene. An e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b10ee783718939f3381f9c8eef4abd8a
https://doi.org/10.1002/chin.200349134
https://doi.org/10.1002/chin.200349134
Autor:
Biqi Wu, Frank Boschelli, Berger Dan Maarten, Dennis Powell, Allan Wissner, Frenel Fils Demorin, Minu Dutia, Jennifer Weber
Publikováno v:
ChemInform. 34
A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08328bdbd11d6856d4fee31dbabf21f
https://doi.org/10.1002/chin.200301144
https://doi.org/10.1002/chin.200301144
Autor:
Adrian L. Smith, Jeffrey Petkus, Carol Babij, Nick A. Paras, Joseph L. Kim, Frenel Fils Demorin, Kristen Hess, Q.T. Le, Josette Carnahan, Andrew Tasker, Linda F. Epstein, Pedro J. Beltran, Douglas A. Whittington, Mark J. Rose, Mquele Ncube, Matthew R. Lee, Qi Huang, Elizabeth M. Doherty, Peter Yakowec, Manory Fernando
Publikováno v:
Cancer Research. 70:2681A-2681A
The Ras-Raf-MAPK signaling pathway plays a central role in diverse cellular processes including differentiation, proliferation and survival. This pathway is activated in a large percentage of cancers as a result of mutations in Ras or in B-Raf Ser/Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::490386bfce8e500a88dfe80448fb35d4
https://doi.org/10.1158/1538-7445.am10-2681a
https://doi.org/10.1158/1538-7445.am10-2681a