openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operation.

Autor: Lightley J; Photonics Group, Physics Department, Imperial College London, London, UK.; Francis Crick Institute, London, UK., Kumar S; Photonics Group, Physics Department, Imperial College London, London, UK.; Francis Crick Institute, London, UK., Lim MQ; Photonics Group, Physics Department, Imperial College London, London, UK.; Department of Surgery and Cancer, Imperial College London, London, UK., Garcia E; Photonics Group, Physics Department, Imperial College London, London, UK.; Department of Surgery and Cancer, Imperial College London, London, UK., Görlitz F; Photonics Group, Physics Department, Imperial College London, London, UK., Alexandrov Y; Photonics Group, Physics Department, Imperial College London, London, UK.; Francis Crick Institute, London, UK., Parrado T; Cairn Research Ltd, Faversham, Kent, England., Hollick C; Cairn Research Ltd, Faversham, Kent, England., Steele E; Cairn Research Ltd, Faversham, Kent, England., Roßmann K; Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany., Graham J; Cairn Research Ltd, Faversham, Kent, England., Broichhagen J; Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany., McNeish IA; Department of Surgery and Cancer, Imperial College London, London, UK., Roufosse CA; Department of Inflammation and Immunology, Imperial College London, London, UK., Neil MAA; Photonics Group, Physics Department, Imperial College London, London, UK.; Francis Crick Institute, London, UK., Dunsby C; Photonics Group, Physics Department, Imperial College London, London, UK.; Francis Crick Institute, London, UK., French PMW; Photonics Group, Physics Department, Imperial College London, London, UK.; Francis Crick Institute, London, UK.

Publikováno v: Journal of microscopy [J Microsc] 2023 Nov; Vol. 292 (2), pp. 64-77. Date of Electronic Publication: 2023 Sep 27.

Single-shot optical projection tomography for high-speed volumetric imaging of dynamic biological samples.

Autor: Darling C; Photonics Group, Department of Physics, Imperial College London, London, UK., Davis SPX; Photonics Group, Department of Physics, Imperial College London, London, UK., Kumar S; Photonics Group, Department of Physics, Imperial College London, London, UK.; Francis Crick Institute, London, UK., French PMW; Photonics Group, Department of Physics, Imperial College London, London, UK.; Francis Crick Institute, London, UK., McGinty J; Photonics Group, Department of Physics, Imperial College London, London, UK.; Francis Crick Institute, London, UK.

Publikováno v: Journal of biophotonics [J Biophotonics] 2023 Feb; Vol. 16 (2), pp. e202200232. Date of Electronic Publication: 2022 Sep 29.

Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice.

Autor: Van de Pette M; Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., Dimond A; Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., Galvão AM; Epigenetics Programme, The Babraham Institute, Cambridge, CB22 3AT, UK.; Institute of Animal Reproduction and Food Research of PAS, Department of Reproductive Immunology and Pathology, Olsztyn, Poland.; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK., Millership SJ; Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., To W; Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., Prodani C; Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., McNamara G; Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., Bruno L; Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., Sardini A; Whole Animal Physiology and Imaging, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., Webster Z; Transgenics and Embryonic Stem Cell Laboratory, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., McGinty J; Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK., French PMW; Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK., Uren AG; Cancer Genomics Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., Castillo-Fernandez J; Epigenetics Programme, The Babraham Institute, Cambridge, CB22 3AT, UK., Watkinson W; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK., Ferguson-Smith AC; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK., Merkenschlager M; Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., John RM; Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK., Kelsey G; Epigenetics Programme, The Babraham Institute, Cambridge, CB22 3AT, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK.; Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, Cambridge, CB2 0QQ, UK., Fisher AG; Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK. amanda.fisher@lms.mrc.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 May 05; Vol. 13 (1), pp. 2464. Date of Electronic Publication: 2022 May 05.

In vivo multiphoton microscopy using a handheld scanner with lateral and axial motion compensation

Autor: Sherlock, B, Warren, SC, Alexandrov, Y, Yu, F, Stone, J, Knight, J, Neil, MAA, Paterson, C, French, PMW, Dunsby, CW

This paper reports a handheld multiphoton fluorescence microscope designed for clinical imaging that incorporates axial motion compensation and lateral image stabilization. Spectral domain optical coherence tomography is employed to track the axial p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::0629279a18569efa28c1049a86e4a2c7
http://hdl.handle.net/10044/1/50536

Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways.

Autor: Guglielmi L; Developmental Signalling Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., Heliot C; Developmental Signalling Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., Kumar S; Advanced Light Microscopy, The Francis Crick Institute, London, NW1 1AT, UK., Alexandrov Y; Advanced Light Microscopy, The Francis Crick Institute, London, NW1 1AT, UK., Gori I; Developmental Signalling Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., Papaleonidopoulou F; Developmental Signalling Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., Barrington C; Bioinformatics and Biostatistics Facility, The Francis Crick Institute, London, NW1 1AT, UK., East P; Bioinformatics and Biostatistics Facility, The Francis Crick Institute, London, NW1 1AT, UK., Economou AD; Developmental Signalling Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., French PMW; Department of Physics, Imperial College London, SW7 2AZ, London, UK., McGinty J; Department of Physics, Imperial College London, SW7 2AZ, London, UK., Hill CS; Developmental Signalling Laboratory, The Francis Crick Institute, London, NW1 1AT, UK. caroline.hill@crick.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2021 Nov 04; Vol. 12 (1), pp. 6374. Date of Electronic Publication: 2021 Nov 04.