MicroRNA-146a deficiency enhances host protection against murine cytomegalovirus.

Autor: Wong P; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Leong JW; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Sohn H; Divison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA., Chang L; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Keppel CR; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Neal CC; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Cubitt CC; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Yao T; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Keppel MP; Divison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA., Tran J; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Burdi A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Hwang K; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Fogel LA; Divison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA., Schappe T; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Marsala L; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Berrien-Elliott MM; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Wagner JA; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Schneider SE; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Sullivan RP; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Pingel JT; Divison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA., Cooper MA; Divison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA., French AR; Divison of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA., Fehniger TA; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

Publikováno v: European journal of immunology [Eur J Immunol] 2024 Sep 09, pp. e2451173. Date of Electronic Publication: 2024 Sep 09.

Human PLCG2 haploinsufficiency results in a novel natural killer cell immunodeficiency.

Autor: Alinger JB; Division of Rheumatology, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo., Mace EM; Departments of Pediatrics, Baylor College of Medicine, Center for Human Immunobiology, Texas Children's Hospital, Houston, Tex; Center for Human Immunobiology, Texas Children's Hospital, Houston, Tex; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Porter JR; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Mo., Mah-Som AY; Division of Rheumatology, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo., Daugherty AL; Division of Rheumatology, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo., Li S; Division of Rheumatology, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo., Throm AA; Division of Rheumatology, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo., Pingel JT; Division of Rheumatology, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo., Saucier N; Division of Rheumatology, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo., Yao A; Division of Rheumatology, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo., Chinn IK; Departments of Pediatrics, Baylor College of Medicine, Center for Human Immunobiology, Texas Children's Hospital, Houston, Tex; Center for Human Immunobiology, Texas Children's Hospital, Houston, Tex., Lupski JR; Departments of Molecular and Human Genetics, Baylor College of Medicine, Texas Children's Hospital, Houston, Tex., Ehlayel M; Hamad Medical Center, Doha, Qatar., Keller M; Children's National Medical Center, Washington, DC., Bowman GR; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Mo., Cooper MA; Division of Rheumatology, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo., Orange JS; Departments of Pediatrics, Baylor College of Medicine, Center for Human Immunobiology, Texas Children's Hospital, Houston, Tex; Center for Human Immunobiology, Texas Children's Hospital, Houston, Tex; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., French AR; Division of Rheumatology, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo. Electronic address: french_a@wustl.edu.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2024 Jan; Vol. 153 (1), pp. 216-229. Date of Electronic Publication: 2023 Sep 13.

Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor.

Autor: Hennessy MR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States., Gutridge AM; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States., French AR; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.; Departments of Neurology and Bioengineering, University of Illinois Chicago, Chicago, Illinois 60612, United States., Rhoda ES; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States., Meqbil YJ; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States., Gill M; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States., Kashyap Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States., Appourchaux K; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States., Paul B; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States., Wang ZJ; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States.; Departments of Neurology and Bioengineering, University of Illinois Chicago, Chicago, Illinois 60612, United States., van Rijn RM; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue Institute for Drug Discovery, West Lafayette, Indiana 47907, United States.; Purdue Institute for Integrative Neuroscience, West Lafayette, Indiana 47907, United States.; Purdue Interdisciplinary Life Sciences Graduate Program, Purdue University, West Lafayette, Indiana 47907, United States., Riley AP; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Mar 09; Vol. 66 (5), pp. 3312-3326. Date of Electronic Publication: 2023 Feb 24.

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Sex- and β-arrestin-dependent effects of kappa opioid receptor-mediated ethanol consumption.

Autor: French AR; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, 207 S Martin Jischke Dr Rm 399, West Lafayette, IN 47907, USA. Electronic address: french35@purdue.edu., Gutridge AM; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA., Yuan J; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA., Royer QH; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA., van Rijn RM; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, 207 S Martin Jischke Dr Rm 399, West Lafayette, IN 47907, USA; Purdue Institute for Drug Discovery, Purdue University, 720 Clinic Dr, West Lafayette, IN 47907, USA.

Publikováno v: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2022 May; Vol. 216, pp. 173377. Date of Electronic Publication: 2022 Mar 29.