Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Frej, Fyhrquist"'
Autor:
Marja-Liisa Nuotio, Heini Sánez Tähtisalo, Alexandra Lahtinen, Kati Donner, Frej Fyhrquist, Markus Perola, Kimmo K Kontula, Timo P Hiltunen
Publikováno v:
Epigenetics, Vol 17, Iss 11, Pp 1432-1445 (2022)
Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium
Externí odkaz:
https://doaj.org/article/3886df2fafc04d18ac28f8e6d59d411c
Autor:
Ilkka Pörsti, Milja Honkonen, Kati Vääräniemi, Outi Saijonmaa, Antti Tikkakoski, Jenni Koskela, Arttu Eräranta, Mika Kähönen, Jukka Mustonen, Frej Fyhrquist
Publikováno v:
Artery Research, Vol 25, Iss 1 (2020)
Background: Telomeres are short segments in chromosome ends, the length of which is reduced during cell life-cycles. We examined the association of leukocyte telomere length and short telomere proportion with hemodynamic variables. Methods: Altogeth
Externí odkaz:
https://doaj.org/article/209694c154ab4037b53e210e7be15440
Autor:
Sonal Singh, Helen R. Warren, Timo P. Hiltunen, Caitrin W. McDonough, Nihal El Rouby, Erika Salvi, Zhiying Wang, Tatiana Garofalidou, Frej Fyhrquist, Kimmo K. Kontula, Valeria Glorioso, Roberta Zaninello, Nicola Glorioso, Carl J. Pepine, Patricia B. Munroe, Stephan T. Turner, Arlene B. Chapman, Eric Boerwinkle, Julie A. Johnson, Yan Gong, Rhonda M. Cooper‐DeHoff
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 16 (2019)
BackgroundThere exists a wide interindividual variability in blood pressure (BP) response to β1‐blockers. To identify the genetic determinants of this variability, we performed a pharmacogenomic genome‐wide meta‐analysis of genetic variants in
Externí odkaz:
https://doaj.org/article/b76016c9f3e14e62a179e21bf16df078
Autor:
Niina Pitkänen, Katja Pahkala, Suvi P. Rovio, Outi J. Saijonmaa, Anna E. Nyman, Antti Jula, Hanna Lagström, Jorma S. A. Viikari, Tapani Rönnemaa, Harri Niinikoski, Olli Simell, Frej Fyhrquist, Olli T. Raitakari
Publikováno v:
Nutrients, Vol 13, Iss 2, p 318 (2021)
Reduced telomere length (TL) is a biological marker of aging. A high inter-individual variation in TL exists already in childhood, which is partly explained by genetics, but also by lifestyle factors. We examined the influence of a 20-year dietary/li
Externí odkaz:
https://doaj.org/article/fcf1766ea00c466cac9ec9f27213732e
Autor:
Juha Virolainen, Kimmo Porthan, Frej Fyhrquist, Sanni Ruotsalainen, Kimmo Kontula, Timo P. Hiltunen, Nina Mars, Samuli Ripatti, Heini Sánez Tähtisalo, Lasse Oikarinen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS al
Autor:
Kati Vääräniemi, Mika Kähönen, Arttu Eräranta, Antti Tikkakoski, Milja Honkonen, Jukka Mustonen, Jenni Koskela, Frej Fyhrquist, Outi Saijonmaa, Ilkka Pörsti
Publikováno v:
Artery Research, Vol 25, Iss 1 (2020)
Background: Telomeres are short segments in chromosome ends, the length of which is reduced during cell life-cycles. We examined the association of leukocyte telomere length and short telomere proportion with hemodynamic variables. Methods: Altogethe
Autor:
Ilkka Pörsti, Mika Kähönen, Terho Lehtimäki, Anna E. Nyman, Kati Vääräniemi, Milja Honkonen, Antti Tikkakoski, Frej Fyhrquist, Outi Saijonmaa, Jenni Koskela, Jukka Mustonen
Publikováno v:
Aging (Albany NY)
Telomeres are short segments in chromosome ends, the length of which is reduced during cell lifecycles. We examined the association of mean leukocyte telomere length (LTL) and short telomere proportion (STP) with hemodynamic variables in normotensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93974a5236622ec0d675fd82af5a925f
https://trepo.tuni.fi/handle/10024/123041
https://trepo.tuni.fi/handle/10024/123041
Publikováno v:
Pharmacogenomics. 19:517-527
Aim: To recognize genetic associations of hydrochlorothiazide-induced change in serum uric acid (SUA) concentration. Patients & methods: We conducted a genome-wide association study on hydrochlorothiazide-induced change in SUA in 214 Finnish men from
Publikováno v:
Journal of the American College of Cardiology. 70:196-211
The generation of reactive oxygen species (ROS) is a fundamental aspect of normal human biology. However, when ROS generation exceeds endogenous antioxidant capacity, oxidative stress arises. If unchecked, ROS production and oxidative stress mediate
Autor:
Kimmo Kontula, Rhonda M. Cooper-DeHoff, Caitrin W. McDonough, Timo P. Hiltunen, Frej Fyhrquist, Stephan T. Turner, Zhiying Wang, Nicola Glorioso, Eric Boerwinkle, Erika Salvi, Helen R. Warren, Arlene B. Chapman, Tatiana Garofalidou, Julie A. Johnson, Nihal El Rouby, Roberta Zaninello, Sonal Singh, Yan Gong, Carl J. Pepine, Valeria Glorioso, Patricia B. Munroe
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background There exists a wide interindividual variability in blood pressure ( BP ) response to β 1 ‐blockers. To identify the genetic determinants of this variability, we performed a pharmacogenomic genome‐wide meta‐analysis of genetic varian