Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Freija G. Glansdorp"'
Autor:
Gemma L. Thomas, Richard J. Spandl, Freija G. Glansdorp, Martin Welch, Andreas Bender, Joshua Cockfield, Jodi A. Lindsay, Clare Bryant, Derek F. J. Brown, Olivier Loiseleur, Hélène Rudyk, Mark Ladlow, David R. Spring
Publikováno v:
Angewandte Chemie. 120:2850-2854
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf72d30bf63d01d640e348a4c8593b0d
https://doi.org/10.1002/ange.200705415
https://doi.org/10.1002/ange.200705415
Autor:
Freija G. Glansdorp, Derek F. J. Brown, Mark Ladlow, Gemma L. Thomas, Joshua D. Cockfield, Jodi A. Lindsay, Helene Rudyk, Martin Welch, David R. Spring, Olivier Loiseleur, Andreas Bender, Richard J. Spandl, Clare E. Bryant
Publikováno v:
Angewandte Chemie International Edition. 47:2808-2812
Antibacterial drugs have played an essential role in the global increase in quality of life and life expectancy. However, these gains are at serious risk owing to bacterial drug resistance by so-called “superbugs”, such as methicillin-resistant S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df18e421f9b276e7297a4e592d1baece
https://doi.org/10.1002/anie.200705415
https://doi.org/10.1002/anie.200705415
Autor:
Declan M. Roche, David R. Spring, Debra S. Smith, Martin Welch, Joseph T. Byers, Freija G. Glansdorp
Publikováno v:
Microbiology. 150:2023-2028
A number of bacteria, including some significant pathogens, utilize N-acylhomoserine lactones (AHLs) as quorum sensing signals. There is considerable interest in the therapeutic potential of disrupting quorum sensing. Recently, a number of bacteria h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247c81808f277565db8fca1288b489d3
https://doi.org/10.1099/mic.0.26977-0
https://doi.org/10.1099/mic.0.26977-0
Autor:
Martin Welch, David R. Spring, Olivier Loiseleur, Jane E. Swatton, Richard J. Spandl, Freija G. Glansdorp
Publikováno v:
Organicbiomolecular chemistry. 6(22)
The antibacterial drug azithromycin has clinically beneficial effects at sub-inhibitory concentrations for the treatment of conditions characterized by chronic Pseudomonas aeruginosa infection, such as cystic fibrosis. These effects are, in part, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9141ed31c56e48be95dd78152831e380
https://pubmed.ncbi.nlm.nih.gov/18972042
https://pubmed.ncbi.nlm.nih.gov/18972042
Autor:
David M. Marsden, Robert C. Glen, Freija G. Glansdorp, Gemma L. Thomas, Emma E. Wyatt, Richard J. Spandl, Rebecca L. Nicholson, Andreas Bender, David R. Spring, Warren R. J. D. Galloway, Suzanne Fergus
Publikováno v:
Ernst Schering Research Foundation Workshop ISBN: 9783540278658
This article covers the diversity-oriented synthesis (DOS) of small molecules in order to generate a collection of pure compounds that are attractive for lead generation in a phenotypic, high-throughput screening approach useful for chemical genetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::838406e84f999f4c28b06b1e8cb2e2e6
https://doi.org/10.1007/978-3-540-37635-4_4
https://doi.org/10.1007/978-3-540-37635-4_4
Autor:
Gemma L. Thomas, Helga Mikkelsen, Freija G. Glansdorp, Debra S. Smith, David R. Spring, Martin Welch, Jane E. Swatton
Publikováno v:
Molecular bioSystems. 1(3)
Over the last decade or so, a wealth of research has established that bacteria communicate with one another using small molecules. These signals enable the individuals in a population to coordinate their behaviour. In the case of pathogens, this beha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47bfa4eeff8c280ba3a1a37306de5c17
https://pubmed.ncbi.nlm.nih.gov/16880983
https://pubmed.ncbi.nlm.nih.gov/16880983
Autor:
Freija G. Glansdorp, Sarah J. Coulthurst, Debra S. Smith, Anne M. L. Barnard, George P. C. Salmond, Martin Welch, David R. Spring, Jenny M. Dutton, Gemma L. Thomas
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(19)
Production of virulence factors and secondary metabolites is regulated in the phytopathogen Erwinia carotovora by quorum sensing involving N-acylated homoserine lactone (AHL) signaling molecules. Non-hydrolyzable AHL analogues were synthesized and sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7c80fc68e2f44a3d16055468b7f689
https://pubmed.ncbi.nlm.nih.gov/16051488
https://pubmed.ncbi.nlm.nih.gov/16051488
Autor:
George P. C. Salmond, David R. Spring, Freija G. Glansdorp, Jungjoon K. Lee, Gemma L. Thomas, Jenny M. Dutton, Martin Welch
Publikováno v:
Organicbiomolecular chemistry. 2(22)
The human pathogen Pseudomonas aeruginosa uses N-butyryl-L-homoserine lactone (BHL) and N-(3-oxododecanyl)-L-homoserine lactone (OdDHL) as small molecule intercellular signals in a phenomenon known as quorum sensing (QS). QS modulators are effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1849c081657c05b197aaf40e66cb86a4
https://pubmed.ncbi.nlm.nih.gov/15534711
https://pubmed.ncbi.nlm.nih.gov/15534711
Autor:
George P. C. Salmond, David R. Spring, Jungjoon K. Lee, Jenny M. Dutton, Martin Welch, Freija G. Glansdorp, Gemma L. Thomas
Publikováno v:
Proceedings of the Chemical Society. :1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21cf6b9f23864a6e52783c82b94fa485
https://doi.org/10.1039/ps9630000001
https://doi.org/10.1039/ps9630000001