MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer

Autor: Augert, Arnaud, Mathsyaraja, Haritha, Ibrahim, Ali H., Freie, Brian, Geuenich, Michael J., Cheng, Pei-Feng, Alibeckoff, Sydney P., Wu, Nan, Hiatt, Joseph B., Basom, Ryan, Gazdar, Adi, Sullivan, Lucas B., Eisenman, Robert N., MacPherson, David

Publikováno v: In Cancer Cell 13 July 2020 38(1):97-114

The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis.

Autor: Carroll, Patrick A.¹ (AUTHOR), Freie, Brian W.¹ (AUTHOR), Cheng, Pei Feng¹ (AUTHOR), Kasinathan, Sivakanthan¹ (AUTHOR), Gu, Haiwei² (AUTHOR), Hedrich, Theresa¹ (AUTHOR), Dowdle, James A.³ (AUTHOR), Venkataramani, Vivek⁴ (AUTHOR), Ramani, Vijay⁵ (AUTHOR), Wu, Xiaoying¹ (AUTHOR), Raftery, Daniel² (AUTHOR), Shendure, Jay^5,6,7 (AUTHOR), Ayer, Donald E.⁸ (AUTHOR), Muller, Charles H.⁹ (AUTHOR), Eisenman, Robert N.¹ (AUTHOR) eisenman@fredhutch.org

Publikováno v: PLoS Biology. 10/20/2021, Vol. 19 Issue 10, p1-38. 38p. 5 Color Photographs, 4 Diagrams, 1 Graph.

Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy

Autor: Li, Xiaxin, Le Beau, Michelle M., Ciccone, Samantha, Yang, Feng-Chun, Freie, Brian, Chen, Shi, Yuan, Jin, Hong, Ping, Orazi, Attilio, Haneline, Laura S., Clapp, D.Wade ^*

Publikováno v: In Blood 1 May 2005 105(9):3465-3471

Continuous in vivo infusion of interferon-gamma (IFN-γ) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc-/- mice

Autor: Li, Xiaxin, Yang, Yanzhu, Yuan, Jin, Hong, Ping, Freie, Brian, Orazi, Attilio, Haneline, Laura S., Clapp, D. Wade ^*

Publikováno v: In Blood 15 August 2004 104(4):1204-1209

A Positive Role for the Ku Complex in DNA Replication Following Strand Break Damage in Mammals

Autor: Park, Su-Jung ^{‡, §, ¶}, Ciccone, Samantha L.M. ^∥, Freie, Brian ^∥, Kurimasa, Akihiro ^**, Chen, David J. ^**, Li, Gloria C. ^‡‡, Clapp, D. Wade ^{∥, §§}, Lee, Suk-Hee ^{‡, §, ¶¶}

Publikováno v: In Journal of Biological Chemistry 13 February 2004 279(7):6046-6055