A multi-organ, lung-derived inflammatory response following in vitro airway exposure to cigarette smoke and next-generation nicotine delivery products

Autor: Bedford, R., Smith, G., Rothwell, E., Martin, S., Medhane, R., Casentieri, D., Daunt, A., Freiberg, G., Hollings, M.

Publikováno v: In Toxicology Letters 15 September 2023 387:35-49

Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening.

Autor: Kumar A; Infectious Disease Research Institute, Seattle, WA, 98102, USA.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, 98109, USA., Chettiar S; Infectious Disease Research Institute, Seattle, WA, 98102, USA., Brown BS; AbbVie Inc., North Chicago, IL, USA., Early J; Infectious Disease Research Institute, Seattle, WA, 98102, USA.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, 98109, USA., Ollinger J; Infectious Disease Research Institute, Seattle, WA, 98102, USA., Files M; Infectious Disease Research Institute, Seattle, WA, 98102, USA., Bailey MA; Infectious Disease Research Institute, Seattle, WA, 98102, USA., Korkegian A; Infectious Disease Research Institute, Seattle, WA, 98102, USA., Dennison D; Infectious Disease Research Institute, Seattle, WA, 98102, USA., McNeil M; Infectious Disease Research Institute, Seattle, WA, 98102, USA., Metz J; AbbVie Inc., North Chicago, IL, USA., Osuma A; AbbVie Inc., North Chicago, IL, USA., Curtin M; AbbVie Inc., North Chicago, IL, USA., Kunzer A; AbbVie Inc., North Chicago, IL, USA., Freiberg G; AbbVie Inc., North Chicago, IL, USA., Bruncko M; AbbVie Inc., North Chicago, IL, USA., Kempf D; AbbVie Inc., North Chicago, IL, USA., Parish T; Infectious Disease Research Institute, Seattle, WA, 98102, USA. tanya.parish@seattlechildrens.org.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, 98109, USA. tanya.parish@seattlechildrens.org.

Publikováno v: Scientific reports [Sci Rep] 2022 Sep 01; Vol. 12 (1), pp. 14879. Date of Electronic Publication: 2022 Sep 01.

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.

Autor: Ray PC; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Huggett M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Turner PA; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Taylor M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Cleghorn LAT; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Early J; TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States., Kumar A; TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States., Bonnett SA; TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States., Flint L; TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States., Joerss D; TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States., Johnson J; TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States., Korkegian A; TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States., Mullen S; TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States., Moure AL; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Davis SH; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Murugesan D; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Mathieson M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Caldwell N; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Engelhart CA; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States., Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States., Epemolu O; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Zuccotto F; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Riley J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Scullion P; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Stojanovski L; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Massoudi L; Mycobacteria Research Laboratories, Colorado State University, 200 W. Lake Street, Fort Collins, Colorado 80523-1682, United States., Robertson GT; Mycobacteria Research Laboratories, Colorado State University, 200 W. Lake Street, Fort Collins, Colorado 80523-1682, United States., Lenaerts AJ; Mycobacteria Research Laboratories, Colorado State University, 200 W. Lake Street, Fort Collins, Colorado 80523-1682, United States., Freiberg G; AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kempf DJ; AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Masquelin T; Discovery Chemistry Research, Eli Lilly and Company, Lilly Corporate Centre, MC/87/02/203, G17, Indianapolis, Indiana 46285, United States., Hipskind PA; Lgenia Inc., Fortville, Indiana 46040, United States., Odingo J; TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States., Read KD; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Green SR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Wyatt PG; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Parish T; TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States.

Publikováno v: ACS omega [ACS Omega] 2021 Jan 13; Vol. 6 (3), pp. 2284-2311. Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021).

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

Autor: Vidadala RS; Department of Chemistry, University of Washington , Seattle, Washington 98195, United States., Rivas KL; Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington , Seattle, Washington 98109, United States., Ojo KK; Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington , Seattle, Washington 98109, United States., Hulverson MA; Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington , Seattle, Washington 98109, United States., Zambriski JA; Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University , Pullman, Washington 99164, United States., Bruzual I; Portland VA Medical Center , Portland, Oregon 97239, United States., Schultz TL; Department of Microbiology and Immunology, University of Michigan Medical School , Ann Arbor, Michigan 48109, United States., Huang W; Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States., Zhang Z; Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States., Scheele S; Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States., DeRocher AE; Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States., Choi R; Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington , Seattle, Washington 98109, United States., Barrett LK; Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington , Seattle, Washington 98109, United States., Siddaramaiah LK; Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States., Hol WG; Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States., Fan E; Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States., Merritt EA; Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States., Parsons M; Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States.; Department of Global Health, University of Washington , Seattle, Washington 98195, United States., Freiberg G; AbbVie , North Chicago, Illinois 60064, United States., Marsh K; AbbVie , North Chicago, Illinois 60064, United States., Kempf DJ; AbbVie , North Chicago, Illinois 60064, United States., Carruthers VB; Department of Microbiology and Immunology, University of Michigan Medical School , Ann Arbor, Michigan 48109, United States., Isoherranen N; Department of Pharmaceutics, University of Washington , Seattle, Washington 98195, United States., Doggett JS; Portland VA Medical Center , Portland, Oregon 97239, United States., Van Voorhis WC; Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington , Seattle, Washington 98109, United States.; Department of Global Health, University of Washington , Seattle, Washington 98195, United States., Maly DJ; Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States.; Department of Chemistry, University of Washington , Seattle, Washington 98195, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Jul 14; Vol. 59 (13), pp. 6531-46. Date of Electronic Publication: 2016 Jul 01.

Mitochondrial Oxidative Stress Is the General Reason for Apoptosis Induced by Different-Valence Heavy Metals in Cells and Mitochondria.

Autor: Korotkov, Sergey M.¹ (AUTHOR) sergey-korotkov@mail.ru

Publikováno v: International Journal of Molecular Sciences. Oct2023, Vol. 24 Issue 19, p14459. 35p.