Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation.

Autor: Tsou AM; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA. amt9052@med.cornell.edu.; Harvard Medical School, Boston, MA, USA. amt9052@med.cornell.edu.; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medical College, New York, NY, USA. amt9052@med.cornell.edu.; Division of Pediatric Gastroenterology and Nutrition, Weill Cornell Medical College, New York, NY, USA. amt9052@med.cornell.edu., Goettel JA; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Bao B; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Biswas A; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kang YH; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Redhu NS; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Peng K; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China., Putzel GG; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medical College, New York, NY, USA., Saltzman J; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA., Kelly R; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA., Gringauz J; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA., Barends J; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA., Hatazaki M; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medical College, New York, NY, USA., Frei SM; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Emani R; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Huang Y; Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China., Shen Z; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA., Fox JG; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA., Glickman JN; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Horwitz BH; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Emergency Medicine, Boston Children's Hospital, Boston, MA, USA., Snapper SB; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA. scott.snapper@childrens.harvard.edu.; Harvard Medical School, Boston, MA, USA. scott.snapper@childrens.harvard.edu.; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA. scott.snapper@childrens.harvard.edu.

Publikováno v: Microbiome [Microbiome] 2021 Nov 03; Vol. 9 (1), pp. 215. Date of Electronic Publication: 2021 Nov 03.

Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.

Autor: Shouval DS; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Biswas A; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Kang YH; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Griffith AE; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Konnikova L; Harvard Medical School, Boston, MA, USA.; Divsion of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Mascanfroni ID; Harvard Medical School, Boston, MA, USA.; Ann Romney Center for Neurological Diseases, Brigham and Women's Hospital, Boston, MA, USA., Redhu NS; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Frei SM; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Field M; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Doty AL; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Immunology and Laboratory Medicine and, University of Florida, FL, USA., Goldsmith JD; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Boston Children's Hospital, Boston, MA, USA., Bhan AK; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Loizides A; Division of Gastroenterology and Nutrition, The Children's Hospital at Montefiore, Bronx, NY, USA.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Weiss B; Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Yerushalmi B; Pediatric Gastroenterology Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Yanagi T; Department of Pediatrics, Kurume University School of Medicine, Kurume, Japan.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Lui X; Department of Pathology, Immunology and Laboratory Medicine and, University of Florida, FL, USA., Quintana FJ; Harvard Medical School, Boston, MA, USA.; Ann Romney Center for Neurological Diseases, Brigham and Women's Hospital, Boston, MA, USA., Muise AM; Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada.; Institute of Medical Science, and Department of Biochemistry, University of Toronto, Toronto, ON, Canada.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Klein C; Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Horwitz BH; Harvard Medical School, Boston, MA, USA.; Department of Pathology Brigham and Women's Hospital, Boston, MA, USA.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Glover SC; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Immunology and Laboratory Medicine and, University of Florida, FL, USA.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Bousvaros A; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Snapper SB; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; VEO-IBD International Consortium, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA.

Publikováno v: Gastroenterology [Gastroenterology] 2016 Dec; Vol. 151 (6), pp. 1100-1104. Date of Electronic Publication: 2016 Sep 28.

Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis.

Autor: Hansbro PM; From the Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales 2308, Australia., Hamilton MJ; the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115., Fricker M; From the Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales 2308, Australia., Gellatly SL; From the Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales 2308, Australia., Jarnicki AG; From the Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales 2308, Australia., Zheng D; the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115., Frei SM; the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115., Wong GW; the Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and., Hamadi S; the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115., Zhou S; the Department of Infectious Disease, Immunology, and Sexual Health, St. George Hospital and the University of New South Wales, Kogarah, New South Wales 2217, Australia., Foster PS; From the Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales 2308, Australia., Krilis SA; the Department of Infectious Disease, Immunology, and Sexual Health, St. George Hospital and the University of New South Wales, Kogarah, New South Wales 2217, Australia., Stevens RL; the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, rstevens@rics.bwh.harvard.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2014 Jun 27; Vol. 289 (26), pp. 18214-27. Date of Electronic Publication: 2014 May 12.

A role for tumor necrosis factor and bacterial antigens in the pathogenesis of Crohn's disease-associated fistulae.

Autor: Frei SM; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; †Department of Pathology, Institute of Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland; ‡Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland; §Department of Surgery, Oberschwaben-Klinik, Ravensburg, Germany; and ‖Division of Gastroenterology and Hepatology, Stadtspital Triemli, Zurich, Switzerland., Pesch T, Lang S, Weber A, Jehle E, Vavricka SR, Fried M, Rogler G, Scharl M

Publikováno v: Inflammatory bowel diseases [Inflamm Bowel Dis] 2013 Dec; Vol. 19 (13), pp. 2878-87.