Conformational plasticity of ligand-bound and ternary GPCR complexes studied by ¹⁹ F NMR of the β 1 -adrenergic receptor.

Autor: Frei JN; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Broadhurst RW; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Bostock MJ; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.; Biomolecular NMR and Center for Integrated Protein Science Munich at Department Chemie, Technical University of Munich, Lichtenbergstraße 4, 85747, Garching, Germany., Solt A; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Jones AJY; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Gabriel F; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Tandale A; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Shrestha B; Protein Sciences, CBT, Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland., Nietlispach D; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK. dn206@cam.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2020 Feb 03; Vol. 11 (1), pp. 669. Date of Electronic Publication: 2020 Feb 03.