Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Freek E, Hoebeek"'
Autor:
Oscar H.J. Eelkman Rooda, Lieke Kros, Sade J. Faneyte, Peter J. Holland, Simona V. Gornati, Huub J. Poelman, Nico A. Jansen, Else A. Tolner, Arn M.J.M. van den Maagdenberg, Chris I. De Zeeuw, Freek E. Hoebeek
Publikováno v:
Brain Stimulation, Vol 14, Iss 4, Pp 861-872 (2021)
Background: Epileptic (absence) seizures in the cerebral cortex can be stopped by pharmacological and optogenetic stimulation of the cerebellar nuclei (CN) neurons that innervate the thalamus. However, it is unclear how such stimulation can modify un
Externí odkaz:
https://doaj.org/article/ed9be142ad64400a9f6f93a0ccbcf0d8
Autor:
Daniël B. Dumas, Simona V. Gornati, Youri Adolfs, Tomomi Shimogori, R. Jeroen Pasterkamp, Freek E. Hoebeek
Publikováno v:
Cells, Vol 11, Iss 23, p 3800 (2022)
The main connection from cerebellum to cerebrum is formed by cerebellar nuclei axons that synapse in the thalamus. Apart from its role in coordinating sensorimotor integration in the adult brain, the cerebello-thalamic tract (CbT) has also been impli
Externí odkaz:
https://doaj.org/article/bfe0e94120214b8581f2c77962f526fc
Autor:
Thomas J. Pisano, Zahra M. Dhanerawala, Mikhail Kislin, Dariya Bakshinskaya, Esteban A. Engel, Ethan J. Hansen, Austin T. Hoag, Junuk Lee, Nina L. de Oude, Kannan Umadevi Venkataraju, Jessica L. Verpeut, Freek E. Hoebeek, Ben D. Richardson, Henk-Jan Boele, Samuel S.-H. Wang
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109721- (2021)
Summary: Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding conventional tracing. Here, we quantify pathways between the cerebellum and forebrain by using transsynaptic tracing viruses and a whole-brain analysis pipe
Externí odkaz:
https://doaj.org/article/f6fbdb31b6d84daba6120233ef23a1ec
Autor:
Gerrit Cornelis Beekhof, Catarina Osório, Joshua J White, Scott van Zoomeren, Hannah van der Stok, Bilian Xiong, Ingo HMS Nettersheim, Willem Ashwin Mak, Marit Runge, Francesca Romana Fiocchi, Henk-Jan Boele, Freek E Hoebeek, Martijn Schonewille
Publikováno v:
eLife, Vol 10 (2021)
Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features are at the core of the modular organization of the cerebellum. Previously, we showed that firing activity of PCs differs between ZebrinII-positive and Zebrin
Externí odkaz:
https://doaj.org/article/3e63f4188e7347519436936b6269724f
Autor:
Fieke Terstappen, Anne E. Richter, A. Titia Lely, Freek E. Hoebeek, Ayten Elvan-Taspinar, Arend F. Bos, Wessel Ganzevoort, Anouk Pels, Petra M. Lemmers, Elisabeth M. W. Kooi
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
Objective: Sildenafil is under investigation as a potential agent to improve uteroplacental perfusion in fetal growth restriction (FGR). However, the STRIDER RCT was halted after interim analysis due to futility and higher rates of persistent pulmona
Externí odkaz:
https://doaj.org/article/73b8fefa15fa41f5ac663017bbd59b3e
Autor:
Simona V. Gornati, Carmen B. Schäfer, Oscar H.J. Eelkman Rooda, Alex L. Nigg, Chris I. De Zeeuw, Freek E. Hoebeek
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2690-2704 (2018)
The cerebellum plays a role in coordination of movements and non-motor functions. Cerebellar nuclei (CN) axons connect to various parts of the thalamo-cortical network, but detailed information on the characteristics of cerebello-thalamic connections
Externí odkaz:
https://doaj.org/article/7958ff97741b40bd9eafa8a7509b0b4a
Autor:
Gerrit C. Beekhof, Simona V. Gornati, Cathrin B. Canto, Avraham M. Libster, Martijn Schonewille, Chris I. De Zeeuw, Freek E. Hoebeek
Publikováno v:
Cells, Vol 10, Iss 10, p 2686 (2021)
Purkinje cells (PCs) in the cerebellar cortex can be divided into at least two main subpopulations: one subpopulation that prominently expresses ZebrinII (Z+), and shows a relatively low simple spike firing rate, and another that hardly expresses Zeb
Externí odkaz:
https://doaj.org/article/44720235508d4662a94871c823c11b9d
Autor:
Josine E. G. Vaes, Marit A. Vink, Caroline G. M. de Theije, Freek E. Hoebeek, Manon J. N. L. Benders, Cora H. A. Nijboer
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Diffuse white matter injury (dWMI) is a major cause of morbidity in the extremely preterm born infant leading to life-long neurological impairments, including deficits in cognitive, motor, sensory, psychological, and behavioral functioning. At presen
Externí odkaz:
https://doaj.org/article/09e936b3a0154045b4efc4a5b7a70fd5
Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
Autor:
Saša Peter, Michiel M. ten Brinke, Jeffrey Stedehouder, Claudia M. Reinelt, Bin Wu, Haibo Zhou, Kuikui Zhou, Henk-Jan Boele, Steven A. Kushner, Min Goo Lee, Michael J. Schmeisser, Tobias M. Boeckers, Martijn Schonewille, Freek E. Hoebeek, Chris I. De Zeeuw
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Mutations in SHANK2 are associated with autism spectrum disorders (ASD). Here, Peter et al. show that selective loss of Shank2in Purkinje cells of the mouse cerebellum leads to deficits in plasticity, motor behaviour, and a social behaviour phenotype
Externí odkaz:
https://doaj.org/article/af668473ae724b5ea8dc88a41fcf7ba7
Autor:
R. Jeroen Pasterkamp, Tomomi Shimogori, Youri Adolfs, Freek E. Hoebeek, Simona V. Gornati, Daniël B. Dumas
Publikováno v:
Cells; Volume 11; Issue 23; Pages: 3800
Cells, 11(23):3800. Multidisciplinary Digital Publishing Institute (MDPI)
Cells, 11(23):3800. Multidisciplinary Digital Publishing Institute (MDPI)
Cerebellar projections to the thalamus are a pivotal connection in cerebello-cerebral interactions. Apart from its role in coordinating sensorimotor integration in the adult brain, the cerebello-thalamic projection has also been implemented in develo