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Autor:
Rask-Andersen Mathias, Jacobsson Josefin A, Moschonis George, Ek Anna E, Chrousos George P, Marcus Claude, Manios Yannis, Fredriksson Robert, Schiöth Helgi B
Publikováno v:
BMC Medical Genetics, Vol 13, Iss 1, p 36 (2012)
Abstract Background Recent genome-wide association studies have identified a single nucleotide polymorphism within the last intron of MAP2K5 associated with a higher body mass index (BMI) in adults. MAP2K5 is a component of the MAPK-family intracellu
Externí odkaz:
https://doaj.org/article/ba63502bfa9046d190fb61ed1de7f8b4
Autor:
Rask-Andersen Mathias, Almén Markus, Olausen Hans R, Olszewski Pawel K, Eriksson Jenny, Chavan Rohit A, Levine Allen S, Fredriksson Robert, Schiöth Helgi B
Publikováno v:
BMC Neuroscience, Vol 12, Iss 1, p 117 (2011)
Abstract Background The Fat mass and obesity gene (FTO) has been identified through genome wide association studies as an important genetic factor contributing to a higher body mass index (BMI). However, the molecular context in which this effect is
Externí odkaz:
https://doaj.org/article/48c990a620ee4bfaac5e237b6f237c9d
Publikováno v:
BMC Evolutionary Biology, Vol 11, Iss 1, p 123 (2011)
Abstract Background The drug/metabolite transporter superfamily comprises a diversity of protein domain families with multiple functions including transport of nucleotide sugars. Drug/metabolite transporter domains are contained in both solute carrie
Externí odkaz:
https://doaj.org/article/1cfd16434c3e451f92fe34a6159017eb
Autor:
Levine Allen S, Sreedharan Smitha, Alsiö Johan, Cedernaes Jonathan, Olszewski Pawel K, Shaik Jafar HA, Jacobsson Josefin A, Almén Markus, Fredriksson Robert, Marcus Claude, Schiöth Helgi B
Publikováno v:
BMC Medical Genetics, Vol 11, Iss 1, p 58 (2010)
Abstract Background TMEM18 is a hypothalamic gene that has recently been linked to obesity and BMI in genome wide association studies. However, the functional properties of TMEM18 are obscure. Methods The evolutionary history of TMEM18 was inferred u
Externí odkaz:
https://doaj.org/article/07ce6e4a902b48efa925264bf14ebb48
Autor:
Fredriksson Robert, Vernersson Andreas KE, Säfström Tommy M, Thollesson Mikael, Nordström Karl JV, Hill Tobias, Schiöth Helgi B
Publikováno v:
BMC Evolutionary Biology, Vol 10, Iss 1, p 42 (2010)
Abstract Background Phylogenetic trees based on sequences from a set of taxa can be incongruent due to horizontal gene transfer (HGT). By identifying the HGT events, we can reconcile the gene trees and derive a taxon tree that adequately represents t
Externí odkaz:
https://doaj.org/article/de8e667021144967a81d9f303bf75c41
Autor:
Levine Allen S, Olszewski Pawel K, Shaik Jafar HA, Sreedharan Smitha, Schiöth Helgi B, Fredriksson Robert
Publikováno v:
BMC Genomics, Vol 11, Iss 1, p 17 (2010)
Abstract Background The SLC17 family of transporters transports the amino acids: glutamate and aspartate, and, as shown recently, also nucleotides. Vesicular glutamate transporters are found in distinct species, such as C. elegans, but the evolutiona
Externí odkaz:
https://doaj.org/article/e1ecdc09dc6b43d4a9cd57b4cdb16328
Autor:
Lannfelt Lars, Axelsson Tomas, Risérus Ulf, Jacobsson Josefin A, Schiöth Helgi B, Fredriksson Robert
Publikováno v:
BMC Medical Genetics, Vol 10, Iss 1, p 131 (2009)
Abstract Background Common FTO (fat mass and obesity associated) gene variants have recently been strongly associated with body mass index and obesity in several large studies. Here we set out to examine the association of the FTO variant rs9939609 w
Externí odkaz:
https://doaj.org/article/9b4432e224e64be6823653f4c85d032a
Autor:
Radomska Katarzyna J, Alsiö Johan, Stephansson Olga, Olszewska Agnieszka M, Fredriksson Robert, Olszewski Pawel K, Levine Allen S, Schiöth Helgi B
Publikováno v:
BMC Neuroscience, Vol 10, Iss 1, p 129 (2009)
Abstract Background Polymorphism in the FTO gene is strongly associated with obesity, but little is known about the molecular bases of this relationship. We investigated whether hypothalamic FTO is involved in energy-dependent overconsumption of food
Externí odkaz:
https://doaj.org/article/16acc8abec3146c0ad190eea70ea0629
Publikováno v:
BMC Biology, Vol 7, Iss 1, p 50 (2009)
Abstract Background Membrane proteins form key nodes in mediating the cell's interaction with the surroundings, which is one of the main reasons why the majority of drug targets are membrane proteins. Results Here we mined the human proteome and iden
Externí odkaz:
https://doaj.org/article/d88c77ee4bc042a2a1a703f5d7371e86