Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Fredrik Y, Frejd"'
Autor:
Francesco Lechi, Jonas Eriksson, Luke R. Odell, Olivia Wegrzyniak, John Löfblom, Fredrik Y. Frejd, Bo Zhang, Olof Eriksson
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Background In recent years, the interest in Al[18F]F as a labeling agent for Positron Emission Tomography (PET) radiotracers has risen, as it allows for fast and efficient fluorine-18 labeling by harnessing chelation chemistry. The introduct
Externí odkaz:
https://doaj.org/article/1e47d67acbb5417c88a66699c63b9e28
Autor:
Maryam Oroujeni, Matilda Carlqvist, Eva Ryer, Anna Orlova, Vladimir Tolmachev, Fredrik Y. Frejd
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-19 (2024)
Abstract Background Radionuclide molecular imaging can be used to visualize the expression levels of molecular targets. Affibody molecules, small and high affinity non-immunoglobulin scaffold-based proteins, have demonstrated promising properties as
Externí odkaz:
https://doaj.org/article/3f8212334a824f1798b022f16777c967
Autor:
Olivia Wegrzyniak, Francesco Lechi, Bogdan Mitran, Pierre Cheung, Athanasios Bitzios, Jonas Persson, John Löfblom, Helena Nordström, Jonas Eriksson, Fredrik Y. Frejd, Olle Korsgren, Bo Zhang, Olof Eriksson
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109688- (2024)
Summary: Non-invasive assessment of fibrogenic activity, rather than fibrotic scars, could significantly improve the management of fibrotic diseases and the development of anti-fibrotic drugs. This study explores the potential of an Affibody molecule
Externí odkaz:
https://doaj.org/article/fad25e6180594e048184d89a8e877f10
Autor:
Olivia Wegrzyniak, Bo Zhang, Johanna Rokka, Maria Rosestedt, Bogdan Mitran, Pierre Cheung, Emmi Puuvuori, Sofie Ingvast, Jonas Persson, Helena Nordström, John Löfblom, Fredrik Pontén, Fredrik Y. Frejd, Olle Korsgren, Jonas Eriksson, Olof Eriksson
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Background Platelet-derived growth factor receptor beta (PDGFRβ) is a receptor overexpressed on activated hepatic stellate cells (aHSCs). Positron emission tomography (PET) imaging of PDGFRβ could potentially allow the quantification of fi
Externí odkaz:
https://doaj.org/article/84daea9b1f234c4eacb9912e8eedc172
Autor:
Alessandro Mega, Aman Mebrahtu, Gustav Aniander, Eva Ryer, Annette Sköld, Anna Sandegren, Eva Backström Rydin, Johan Rockberg, Arne Östman, Fredrik Y. Frejd
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTCD40 agonism by systemic administration of CD40 monoclonal antibodies has been explored in clinical trials for immunotherapy of cancer, uncovering enormous potential, but also dosing challenges in terms of systemic toxicity. CD40-dependent ac
Externí odkaz:
https://doaj.org/article/5fcf495d262941deb28a289c2152f86b
Autor:
Susanne Klint, Joachim Feldwisch, Lindvi Gudmundsdotter, Karin Dillner Bergstedt, Elin Gunneriusson, Ingmarie Höidén Guthenberg, Anders Wennborg, Andrew C. Nyborg, Amol P. Kamboj, Paul M. Peloso, David Bejker, Fredrik Y. Frejd
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTPsoriasis, an immune-mediated inflammatory disease, affects nearly 125 million people globally. The interleukin (IL)-17A homodimer is a key driver of psoriasis and other autoimmune diseases, including psoriatic arthritis, axial spondyloarthri
Externí odkaz:
https://doaj.org/article/c8401aa19f3c478fa57e57df7df533f1
Autor:
Renske Altena, Antonios Tzortzakakis, Siri Af Burén, Thuy A. Tran, Fredrik Y. Frejd, Jonas Bergh, Rimma Axelsson
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Background Expanding therapeutic possibilities have improved disease-related prospects for breast cancer patients. Pathological analysis on a tumor biopsy is the current reference standard biomarker used to select for treatment with targeted
Externí odkaz:
https://doaj.org/article/5f9a797e673c485f844cc6142e6ffd0d
Autor:
Nina Eissler, Renske Altena, Ali Alhuseinalkhudhur, Olga Bragina, Joachim Feldwisch, Guido Wuerth, Annika Loftenius, Nikolai Brun, Rimma Axelsson, Vladimir Tolmachev, Jens Sörensen, Fredrik Y. Frejd
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1088 (2024)
Human epidermal growth factor receptor 2 (HER2) is a major prognostic and predictive marker overexpressed in 15–20% of breast cancers. The diagnostic reference standard for selecting patients for HER2-targeted therapy is based on the analysis of tu
Externí odkaz:
https://doaj.org/article/fca4871fc0e24c1fb9ada3331b3daf97
Autor:
Tabassom Mohajershojai, Preeti Jha, Anna Boström, Fredrik Y. Frejd, Paul J. Yazaki, Marika Nestor
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Carcinoembryonic antigen (CEA) is an antigen that is highly expressed in colorectal cancers and widely used as a tumor marker. 131I and 90Y-radiolabeled anti-CEA monoclonal antibodies (mAbs) have previously been assessed for radioimmunotherapy in ear
Externí odkaz:
https://doaj.org/article/4fe414bf2d204697b6e74e4f33eaaeb6
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-26 (2020)
Abstract The use of radiolabelled antibodies was proposed in 1970s for staging of malignant tumours. Intensive research established chemistry for radiolabelling of proteins and understanding of factors determining biodistribution and targeting proper
Externí odkaz:
https://doaj.org/article/db42c34e5db84f77bcac563b3d23119c