Výsledky vyhledávání - "Fredrik Wångsell"

Radical Functionalization of Unsaturated Amino Acids: Synthesis of Side-Chain-Fluorinated, Azido-Substituted, and Hydroxylated Amino Acids

Autor: Urszula Grabowska, Richard F. W. Jackson, Lourdes Salvador Oden, Fredrik Wångsell, Philip A. P. Reeve, Daniel Wiktelius

Publikováno v: ACS Omega, Vol 4, Iss 6, Pp 10854-10865 (2019)
ACS Omega

A range of enantiomerically pure protected side-chain-fluorinated amino acids has been prepared (13 examples) by treatment of protected amino acids containing unsaturated side chains with a combination of Fe(III)/NaBH4 and Selectfluor. The modificati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060b5358a2090280530cef660d3ed91c
https://doaj.org/article/aba17e3c7c414378b660bf2669f91fc2

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Synthesis and labeling of a piperazine-based library of11C-labeled ligands for imaging of the vesicular acetylcholine transporter

Autor: Sara Bergman, Alf Thibblin, Mats Larhed, Håkan Hall, Rashidur Rahman, Andreas Blomgren, Fredrik Wångsell, Gunnar Antoni, Sergio Estrada, Marie M. Svedberg

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 57:525-532

The cholinergic system is involved in neurodegenerative diseases, and visualization of cholinergic innervations with positron emission tomography (PET) would be a useful tool in understanding these ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22481e65d56e079a95e6bf2c79ba1110
https://doi.org/10.1002/jlcr.3208

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Investigation of α-phenylnorstatine and α-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors

Autor: Fredrik Wångsell, Jimmy Lindberg, Mats Larhed, Bertil Samuelsson, Patrik Nordeman, Åsa Rosenquist, Jonas Sävmarker, Rikard Emanuelsson, Katarina Jansson

Publikováno v: Bioorganic & Medicinal Chemistry. 19:145-155

Inhibition of the BACE-1 protease enzyme has over the recent decade developed into a promising drug strategy for Alzheimer therapy. In this report, more than 20 new BACE-1 protease inhibitors based on α-phenylnorstatine, α-benzylnorstatine, iso-ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4429b92e15243f0b1464ba9a0f14b833
https://doi.org/10.1016/j.bmc.2010.11.042

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Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core

Autor: Karin Gustafsson, Jimmy Lindberg, Ingemar Kvarnström, Bertil Samuelsson, Fredrik Wångsell, Anders Hallberg, Åsa Rosenquist, Katarina Jansson, Neera Borkakoti, Michael Edlund

Publikováno v: European Journal of Medicinal Chemistry. 45:870-882

We herein describe the design and synthesis of a series of BACE-1 inhibitors incorporating a P1-substituted hydroxylethylene transition state isostere. The synthetic route starting from commercially available carbohydrates yielded a pivotal lactone i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475d8ec9cdeac6a6b4f84dd45d430a09
https://doi.org/10.1016/j.ejmech.2009.11.013

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Synthesis and evaluation of a new class of tertiary alcohol based BACE-1 inhibitors

Autor: Fredrik Wångsell, Micael Jacobsson, Mats Larhed, Francesco Russo, Jonas Sävmarker

Publikováno v: Tetrahedron. 65:10047-10059

BACE-1 has emerged as one of the best characterized targets for future Alzheimer therapy. In accordance with the successful identification of masked inhibitors of HIV-1 protease, we envisioned ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3e1e17362dcd2c510cc8e058364beac
https://doi.org/10.1016/j.tet.2009.09.106

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Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: Use of cyclopentane and cyclopentene P2-motifs

Autor: Christina Rydergård, Hans Wallberg, Björn Classon, Åsa Rosenquist, Stefan Lindström, Elizabeth Hamelink, Per-Ola Johansson, Bertil Samuelsson, Ingemar Kvarnström, Fredrik Thorstensson, Susana Ayesa, Anders Hallberg, Fredrik Wångsell, Mikael Pelcman, Horst Wähling, Marcus Bäck, Katarina Jansson, Lotta Vrang

Publikováno v: Bioorganic & Medicinal Chemistry. 15:7184-7202

Several highly potent novel HCV NS3 protease inhibitors have been developed from two inhibitor series containing either a P2 trisubstituted macrocyclic cyclopentane- or a P2 cyclopentene dicarboxylic acid moiety as surrogates for the widely used N-ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15921dd4d5e74960f57d655a5ff961ae
https://doi.org/10.1016/j.bmc.2007.07.027

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Synthesis and labeling of a piperazine-based library of ¹¹C-labeled ligands for imaging of the vesicular acetylcholine transporter

Autor: Sara, Bergman, Sergio, Estrada, Håkan, Hall, Rashidur, Rahman, Andreas, Blomgren, Mats, Larhed, Marie, Svedberg, Alf, Thibblin, Fredrik, Wångsell, Gunnar, Antoni

Publikováno v: Journal of labelled compoundsradiopharmaceuticals. 57(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b77a5ad15aa22a81930ec6ebc3309c27
https://pubmed.ncbi.nlm.nih.gov/24991704

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Use of a HEHEHE purification tag instead of a hexahistidine tag improves biodistribution of affibody molecules site-specifically labeled with (99m)Tc, (111)In, and (125)I

Autor: Vladimir Tolmachev, Fredrik Wångsell, Torbjörn Gräslund, Camilla Hofström, Mohamed Altai, Anna Orlova

Publikováno v: Journal of medicinal chemistry. 54(11)

Affibody molecules are a class of small (∼7 kDa) robust scaffold proteins suitable for radionuclide molecular imaging in vivo. The attachment of a hexahistidine (His(6))-tag to the Affibody molecule allows facile purification by immobilized metal i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff64816e52e736697697e937efcd0eb
https://pubmed.ncbi.nlm.nih.gov/21524142

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