Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Fredrik Limé"'
Autor:
Jörgen Samuelsson, Linda Thunberg, Fredrik Limé, Eivor Örnskov, Torgny Fornstedt, Martin Enmark, Joakim Bagge, Hanna Leek
Publikováno v:
Analytical and Bioanalytical Chemistry
Oligonucleotide drugs represent an emerging area in the pharmaceutical industry. Solid-phase synthesis generates many structurally closely related impurities, making efficient separation systems for purification and analysis a key challenge during ph
Publikováno v:
Journal of chromatography. A. 1634
A combined experimental and theoretical study was performed to understand how the pore size of packing materials with pores 60-300 angstrom in size affects the separation of 5-50-mer oligonucleotides. For this purpose, we developed a model in which t
Autor:
David Bernson, Fredrik Limé, Magnus Palmlöf, Almedina Mecinovic, Per Jageland, Elin K. Esbjörner, Tuhin Abed
Publikováno v:
European Biophysics Journal
Protein aggregation and amyloid formation are associated with multiple human diseases, but are also a problem in protein production. Understanding how aggregation can be modulated is therefore of importance in both medical and industrial contexts. We
Publikováno v:
Toxicology Mechanisms and Methods
Aim: Short-time models (STM) to study the cardiotoxicity (acute or chronic) of doxorubicin in rats are of interest to assess protective interventions and pathways. STM promotes more ethical animal treatment with less stress, and at a lower cost compa
Autor:
Fredrik Limé, Knut Irgum
Publikováno v:
Macromolecules. 42:4436-4442
Polymerization of Divinylbenzene and Divinylbenzene-co-Glycidyl Methacrylate Particles by Photoinitiated Precipitation Polymerization in Different Solvent Mixtures
Autor:
Fredrik Limé, Knut Irgum
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 47:1259-1265
Rigid and monodisperse spherical polymer particles with 2.36 ± 0.18 m diameter containing residual surface vinyl groups were prepared by photoinitiated precipitation polymerization of divinylbenzen ...
Autor:
Fredrik Limé, Knut Irgum
Publikováno v:
Macromolecules. 40:1962-1968
Monodisperse polymer particles consisting of DVB and styrene-copoly-DVB were successfully synthesized by photoinitiated precipitation polymerization with 2,2'-azobis(2-methylpropionitrile) (AIBN) a ...
Publikováno v:
Journal of separation science. 33(11)
A combined surface activation and "grafting to" strategy was developed to convert divinylbenzene particles into weak cation exchangers suitable for protein separation. The initial activation step was based on plasma modification with bromoform, which
Publikováno v:
Journal of separation science. 31(12)
A strong cation-exchange separation material has been prepared from monodisperse divinylbenzene particles modified by a "grafting to" approach, utilizing as anchoring points epoxy groups introduced onto the surface of the particles via oxidation of r
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology
BMC Pharmacology and Toxicology
Aim: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to investigate if opening of mitochondria