Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Fredrik Ivars"'
Autor:
Nina Fransén Pettersson, Adnan Deronic, Julia Nilsson, Tine D Hannibal, Lisbeth Hansen, Anja Schmidt-Christensen, Fredrik Ivars, Dan Holmberg
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203228 (2018)
Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Infl
Externí odkaz:
https://doaj.org/article/c440dfa6e5074e2dae8bca47e7e7b38e
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196598 (2018)
Quinoline-3-carboxamides (Q compounds) are immunomodulatory compounds that have shown efficacy both in autoimmune disease and cancer. We have in here investigated the impact of one such compound, paquinimod, on the development of diabetes in the NOD
Externí odkaz:
https://doaj.org/article/b5a72f60bd324bc29af178306e315d57
Autor:
Nina Fransén-Pettersson, Nadia Duarte, Julia Nilsson, Marie Lundholm, Sofia Mayans, Åsa Larefalk, Tine D Hannibal, Lisbeth Hansen, Anja Schmidt-Christensen, Fredrik Ivars, Susanna Cardell, Richard Palmqvist, Björn Rozell, Dan Holmberg
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159850 (2016)
Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic inflammation and fibrosis (N-IF) mouse. In the liver, the N-IF mouse displays inflammation and fibrosis p
Externí odkaz:
https://doaj.org/article/9d3b933356d24c1daeda8f7b7fdf0e2d
Autor:
Zhifei He, Matteo Riva, Per Björk, Karl Swärd, Matthias Mörgelin, Tomas Leanderson, Fredrik Ivars
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156377 (2016)
The cytosolic Ca2+-binding S100A9 and S100A8 proteins form heterodimers that are primarily expressed in human neutrophils and monocytes. We have recently shown that S100A9 binds to TLR4 in vitro and induces TLR4-dependent NF-κB activation and a pro-
Externí odkaz:
https://doaj.org/article/c87468dd5ba6437bb90a2aaf8333ac34
Autor:
Paramita Chakraborty, Per Bjork, Eva Källberg, Anders Olsson, Matteo Riva, Matthias Mörgelin, David Liberg, Fredrik Ivars, Tomas Leanderson
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145217 (2015)
We show here, by using surface biotinylation, followed by Western blotting or surface plasmon resonance analysis, that very low levels of S100A8 and/or S100A9 can be detected on the surface of THP-1 cells or freshly isolated human monocytes. This was
Externí odkaz:
https://doaj.org/article/c74b8a3058df4ee681e5829c71f5b885
Autor:
Per Björk, Eva Källberg, Ulf Wellmar, Matteo Riva, Anders Olsson, Zhifei He, Marie Törngren, David Liberg, Fredrik Ivars, Tomas Leanderson
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63012 (2013)
S100A4 and S100A9 proteins have been described as playing roles in the control of tumor growth and metastasis. We show here that a chemical probe, oxyclozanide (OX), selected for inhibiting the interaction between S100A9 and the receptor for advanced
Externí odkaz:
https://doaj.org/article/ff3b62ac635a4e5284c72f67383f2f8b
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61832 (2013)
S100A8 and S100A9 are Ca(2+)-binding proteins that are associated with acute and chronic inflammation and cancer. They form predominantly heterodimers even if there are data supporting homodimer formation. We investigated the stability of the heterod
Externí odkaz:
https://doaj.org/article/60ecd8b48f514e65b3cc2f26b45e8221
Autor:
Eva Källberg, Thomas Vogl, David Liberg, Anders Olsson, Per Björk, Pernilla Wikström, Anders Bergh, Johannes Roth, Fredrik Ivars, Tomas Leanderson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34207 (2012)
By breeding TRAMP mice with S100A9 knock-out (S100A9(-/-)) animals and scoring the appearance of palpable tumors we observed a delayed tumor growth in animals devoid of S100A9 expression. CD11b(+) S100A9 expressing cells were not observed in normal p
Externí odkaz:
https://doaj.org/article/d85c17eed1b146adad26d0cf47427550
Autor:
Per Björk, Anders Björk, Thomas Vogl, Martin Stenström, David Liberg, Anders Olsson, Johannes Roth, Fredrik Ivars, Tomas Leanderson
Publikováno v:
PLoS Biology, Vol 7, Iss 4, p e97 (2009)
Despite more than 25 years of research, the molecular targets of quinoline-3-carboxamides have been elusive although these compounds are currently in Phase II and III development for treatment of autoimmune/inflammatory diseases in humans. Using phot
Externí odkaz:
https://doaj.org/article/d9b0cf5ec37a4cefa5970058e75fe613
Autor:
Sven Kjellström, Camilla Rydberg Millrud, Meliha Mehmeti, Karin Leandersson, Fredrik Ivars, Per Björk, Bengt Johansson-Lindbom, Eva Källberg, Ingemar André, Caroline Bergenfelz
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications Biology
Communications Biology
Innate immune responses are rapid, dynamic and highly regulated to avoid overt reactions. This regulation is executed by innate immune tolerance mechanisms that remain obscure. Wnt5a is a signalling protein mainly involved in developmental processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11acf8c2c38d9d71875d7dc393a66622
http://link.springer.com/article/10.1038/s42003-019-0432-4
http://link.springer.com/article/10.1038/s42003-019-0432-4