Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Fredrik Hieronymus"'
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Greater initial severity on the 30-item Positive and Negative Syndrome Scale (PANSS-30) correlates positively with antipsychotic-placebo separation and trial dropout, but it is unknown whether these associations are present also on PANSS-der
Externí odkaz:
https://doaj.org/article/496aa5ed84df482f8e06bdd278267f6e
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract The clinical response to selective serotonin reuptake inhibitors (SSRIs) in depression takes weeks to be fully developed and is still not entirely understood. This study aimed to determine the direct and indirect effects of SSRIs relative to
Externí odkaz:
https://doaj.org/article/ad14c02ec3e24461b91091258625d626
Autor:
Magnus Hieronymus, Fredrik Hieronymus
Publikováno v:
Tellus: Series A, Dynamic Meteorology and Oceanography, Vol 75, Iss 1, Pp 129–144-129–144 (2023)
A new machine learning based bias correction method is presented and applied to sea level in a regional climate model. The bias corrections derived using this method depend on the state of the model it corrects. This contrasts with conventional bias
Externí odkaz:
https://doaj.org/article/63fdfa19d87a47448a34485ee9f870f5
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-6 (2022)
Abstract Response defined as a 50% reduction in the sum score of the Hamilton Depression Rating Scale (HDRS-17-sum) is often used to assess the efficacy of antidepressants. Critics have, however, argued that dichotomising ratings with a cutoff close
Externí odkaz:
https://doaj.org/article/c1bcfa5510cb4ac19e3642a7aa30e325
Publikováno v:
npj Schizophrenia, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Several trials have shown preliminary evidence for the efficacy of transcranial magnetic stimulation (TMS) as a treatment for negative symptoms in schizophrenia. Here, we synthesize this literature in a systematic review and quantitative met
Externí odkaz:
https://doaj.org/article/f0e0e0b1add449989d047b44b005074e
Publikováno v:
npj Schizophrenia, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract In order for measurement-based care to be implemented, there is a need for brief rating instruments that can be administered in a short amount of time, but that are still sufficiently informative. Here, we assessed the drug–placebo sensiti
Externí odkaz:
https://doaj.org/article/6e2551eb683541798116ff0d4547bbfa
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The Hamilton Depression Rating Scale (HDRS-17) measures symptoms that may overlap with common antidepressant side effects (e.g., sexual dysfunction), thus making it possible that side effects of antidepressant treatment are erroneously rated
Externí odkaz:
https://doaj.org/article/ed81c0f8f14145648f4d6d8da253d54a
Publikováno v:
IBRO Reports, Vol 6, Iss , Pp 31-39 (2019)
Loud (≥70dBA) acoustic white noise improves cognitive performance in children with ADHD as well as skilled reach and rotarod performance in the spontaneously hypertensive (SH) rat model of ADHD. To investigate how acoustic noise influences the brai
Externí odkaz:
https://doaj.org/article/819eeb246b0b4f7797616edd2f17f30c
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/adac1536196a4070aa3432c618b8dc9c
Determining maximal achievable effect sizes of antidepressant therapies in placebo‐controlled trials
Autor:
Magnus Hieronymus, Jakob Näslund, Søren Dinesen Østergaard, Elias Eriksson, Alexander Lisinski, Fredrik Hieronymus
Publikováno v:
Hieronymus, F, Lisinski, A, Hieronymus, M, Näslund, J, Eriksson, E & Østergaard, S D 2021, ' Determining maximal achievable effect sizes of antidepressant therapies in placebo-controlled trials ', Acta Psychiatrica Scandinavica, vol. 144, no. 3, pp. 300-309 . https://doi.org/10.1111/acps.13340
OBJECTIVE: Antidepressants outperform placebo with an effect size of around 0.30. It has been suggested that effect sizes as high as 0.875 are necessary for a minimal clinically important difference. Whether such effect sizes are achievable in placeb