Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Fredrik Hedborg"'
Autor:
Fredrik Hedborg, Reiner Fischer-Colbrie, Nurtena Ostlin, Bengt Sandstedt, Maxine G B Tran, Patrick H Maxwell
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Neuroblastoma is a childhood malignancy of sympathetic embryonal origin. A high potential for differentiation is a hallmark of neuroblastoma cells. We have previously presented data to suggest that in situ differentiation in tumors frequently proceed
Externí odkaz:
https://doaj.org/article/0e78895037dc4ba782d74124a303d448
Publikováno v:
APMIS. 124:140-149
We studied HERV expression in cell lines after hypoxia, mitogenic stimulation, and demethylation, to better understand if hypoxia may play a role in ERV activation also within the nervous system, as represented by neuroblastoma cell lines. The level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d248adccaf1cf16d60308dc65b3a6d79
https://doi.org/10.1111/apm.12494
https://doi.org/10.1111/apm.12494
Autor:
Jean Michon, Isabelle Janoueix-Lerosey, Olivier Delattre, Julie Cappo, Michel Peuchmaur, Gaëlle Pierron, Bram De Wilde, Ingrid Øra, Catarina Träger, Tommy Martinsson, Britt-Marie Holmqvist, Quentin Leroy, Gudrun Schleiermacher, Valérie Combaret, Eve Lapouble, Fredrik Hedborg, Anna Djos, Thomas Rio Frio, Jonas Abrahamsson, Per Kogner, Franki Speleman, Virginie Bernard, Niloufar Javanmardi
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 32(25)
Purpose In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated the potential role of ALK mutations in neuroblastoma clonal evolution. Methods We analyzed ALK mutations in 54 paired diagnosis–relapse neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa752c644cd90d27c615a8364eb4fc0
https://pubmed.ncbi.nlm.nih.gov/25071110
https://pubmed.ncbi.nlm.nih.gov/25071110
Autor:
Fredrik Hedborg, Margareta Nordling, K Hallstensson, Rose-Marie Sjöberg, Per Kogner, Tommy Martinsson
Publikováno v:
Karolinska Institutet
We analysed DNA from 68 neuroblastoma tumours for loss of heterozygosity (LOH) on the distal chromosome 1p (1p-LOH) using PCR-based DNA polymorphisms. Fifteen tumours (22%) displayed 1p-LOH. The shortest region of overlap (SRO) for the deletions was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56769e55f1c3f766c8f01d6959178662
https://doi.org/10.1016/s0959-8049(97)00278-5
https://doi.org/10.1016/s0959-8049(97)00278-5
Autor:
Levent M. Akyürek, Meena Kanduri, Santhilal Subhash, Zhiyu Peng, Leming Shi, Gaurav Kumar Pandey, Erik Larsson, Susanne Fransson, Tanmoy Mondal, Sanhita Mitra, Malin Östensson, Jonas Abrahamsson, Susan Pfeifer, Abiarchana Ganeshram, Fredrik Hedborg, Sashidhar Bandaru, Matthias Fischer, Falk Hertwig, Per Kogner, Tommy Martinsson, Kankadeb Mishra, Chandrasekhar Kanduri
Publikováno v:
Cancer cell. 26(5)
SummaryNeuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d35e7b9eecfa879212af5a36f51017
https://pubmed.ncbi.nlm.nih.gov/25517750
https://pubmed.ncbi.nlm.nih.gov/25517750
Publikováno v:
International Journal of Cancer. 62:19-24
Apoptosis is the selective physiologic deletion of cells that are no longer required. Over-expression of the bcl-2 proto-oncogene extends survival of neurons otherwise destined for apoptosis. The unique capacity of neuroblastoma (NB) to undergo spont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df44b8ba52807309430c0e7574bdafd
https://doi.org/10.1002/ijc.2910620106
https://doi.org/10.1002/ijc.2910620106
Autor:
Susan Pfeifer-Ohlsson, Virpi Töhönen, Fredrik Hedborg, Paul N. Schofield, Rolf Ohlsson, Folke Flam, Tomas J. Ekström, Anders Nyström
Publikováno v:
Nature Genetics. 4:94-97
The phenomenon of parental imprinting involves the preferential expression of one parental allele of a subset of chromosomal genes and has so far only been documented in the mouse. We show here, by exploiting sequence polymorphisms in exon nine of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77655d95125f92d7b1686db549af329
https://doi.org/10.1038/ng0593-94
https://doi.org/10.1038/ng0593-94
Autor:
Patrick H. Maxwell, Reiner Fischer-Colbrie, Maxine G. B. Tran, Fredrik Hedborg, Bengt Sandstedt, Nurtena Östlin
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
PLoS ONE
PLoS ONE
Background Neuroblastoma is a childhood malignancy of sympathetic embryonal origin. A high potential for differentiation is a hallmark of neuroblastoma cells. We have previously presented data to suggest that in situ differentiation in tumors frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02850ac9e356e1e0e7a9f32710268414
http://europepmc.org/articles/PMC2941466?pdf=render
http://europepmc.org/articles/PMC2941466?pdf=render
Autor:
Sven Påhlman, Irja Johansson, Bengt-Olof Samuelsson, Per Kogner, P. G. Lindgren, Leif Olsen, Anders Kreuger, Albert N. Békássy, Fredrik Hedborg
Publikováno v:
Medical and Pediatric Oncology. 20:292-300
N-myc gene amplification was studied in a consecutive series of neuroblastomas and ganglioneuromas, representing all of such tumours diagnosed in Sweden over a 4-year period. Both frozen and formalin fixed specimens were used for Southern blot analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd006e0defbc080f93479bfc92c6237
https://doi.org/10.1002/mpo.2950200405
https://doi.org/10.1002/mpo.2950200405
Autor:
Erik G, Sköldenberg, Anders, Larsson, Ake, Jakobson, Fredrik, Hedborg, Per, Kogner, Rolf H, Christofferson, Faranak, Azarbayjani
Publikováno v:
Anticancer research. 29(8)
To determine whether concentrations of the angiogenic growth factors hepatocyte growth factor (HGF) and vascular endothelial growth factor A (VEGF-A) correlate with clinical and genetic markers in samples taken at diagnosis in children with neuroblas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4645a8e7af7e24f1adbbc4dcaf0af03
https://pubmed.ncbi.nlm.nih.gov/19661350
https://pubmed.ncbi.nlm.nih.gov/19661350