Using machine learning model explanations to identify proteins related to severity of meibomian gland dysfunction

Autor: Andrea M. Storås, Fredrik Fineide, Morten Magnø, Bernd Thiede, Xiangjun Chen, Inga Strümke, Pål Halvorsen, Hilde Galtung, Janicke L. Jensen, Tor P. Utheim, Michael A. Riegler

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract Meibomian gland dysfunction is the most common cause of dry eye disease and leads to significantly reduced quality of life and social burdens. Because meibomian gland dysfunction results in impaired function of the tear film lipid layer, stu

Externí odkaz: https://doaj.org/article/1f2cb651a6584982951da1bdbb61c507

Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer

Autor: Xiangjun Chen, Reza A. Badian, Håvard Hynne, Cecilie Delphin Amdal, Bente Brokstad Herlofson, Øygunn Aass Utheim, Kristine Løken Westgaard, Fredrik Fineide, Janicke Liaaen Jensen, Tor Paaske Utheim

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)

Abstract Patients undergoing intensity-modulated radiotherapy (IMRT) for head and neck cancer may have increased incidence of dry eye disease and the exact mechanism is unclear. The present study aims to assess tear film and meibomian gland (MG) feat

Externí odkaz: https://doaj.org/article/23ae07d87f134bd186079dedc60e7a69

The role of meibography in ocular surface diagnostics: A review

Autor: Reiko Arita, Fredrik Fineide, Tor Paaske Utheim

Publikováno v: The Ocular Surface. 19:133-144

The meibomian glands are lipid-secreting glands located in the tarsal plates, whose secretory products cover the tear film, thereby reducing evaporation as well as ensuring lubrication of the ocular surface. The meibomian glands can be visualized at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f89dbb24d49e49e51b387f05c73759
https://doi.org/10.1016/j.jtos.2020.05.004

Topical glaucoma medications – Clinical implications for the ocular surface

Autor: Fredrik Fineide, Neil Lagali, Muhammed Yasin Adil, Reiko Arita, Miriam Kolko, Jelle Vehof, Tor P. Utheim

Publikováno v: The ocular surface
Fineide, F, Lagali, N, Adil, M Y, Arita, R, Kolko, M, Vehof, J & Utheim, T P 2022, ' Topical glaucoma medications : Clinical implications for the ocular surface ', Ocular Surface, vol. 26, pp. 19-49 . https://doi.org/10.1016/j.jtos.2022.07.007
The Ocular Surface

Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility of the compound. A growin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fe080dbd908d2982a6dcf756df192e
https://hdl.handle.net/11250/3025183

Characterization of Lipids in Saliva, Tears and Minor Salivary Glands of Sjögren’s Syndrome Patients Using an HPLC/MS-Based Approach

Autor: Valeria Vitelli, Thomas Bjellaas, Xiangjun Chen, Janicke Liaaen Jensen, Hilde Kanli Galtung, Fredrik Fineide, Tor Paaske Utheim

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8997, p 8997 (2021)

The diagnostic work-up of primary Sjögren’s syndrome (pSS) includes quantifying saliva and tear production, evaluation of autoantibodies in serum and histopathological analysis of minor salivary glands. Thus, the potential for further utilizing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4820926a12a37c2b08f0a59fea44f37d
http://hdl.handle.net/10852/89547