Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Fredrik Blomstrand"'
Publikováno v:
Neurochemistry International. 61:291-301
Depressed energy metabolism and oxidative stress are common features in many pathological situations in the brain, including stroke. In order to investigate astrocytic responses to such stress, we induced metabolic depression in cultured rat astrocyt
Autor:
Fredrik Blomstrand, Helene C. Andersson, Michelle J. Porritt, Christina Nodin, Michelle F. Anderson, Michael Nilsson
Publikováno v:
Neurological Research. 33:614-624
Reactive gliosis and scar formation after brain injury can inhibit the recovery process. As many glial cells utilize gap junctions for intercellular signaling, this study investigated whether two commonly used gap junction blockers, octanol and carbe
Autor:
Peter S. Eriksson, Michael Nilsson, Annika Thorsell, Jonas Faijerson, Ann Westman-Brinkmalm, Kaj Blennow, Fredrik Blomstrand
Publikováno v:
Journal of Proteomics & Bioinformatics. :128-142
Development of strategies that allow for identification of secreted factors in conditioned media is of significance for a wide range of research areas. Secreted factors are involved in intercellular communication and might also be biomarkers of poten
Publikováno v:
Journal of Biological Chemistry. 283:10347-10356
Omission of extracellular Ca2+ for 15 min from the incubation medium of cultured hippocampal slices stimulated the efflux of glutathione, phosphoethanolamine, hypotaurine, and taurine. The efflux was reduced by several blockers of gap junctions, i.e.
Publikováno v:
The Journal of Physiology. 585:843-852
Active synapses can reduce the probability of transmitter release at neighbouring synapses. Depending on whether such heterosynaptic depression is mediated by intersynaptic diffusion of transmitter or by release of gliotransmitters, astrocytes should
Autor:
Karina Aprico, Andrew P. Fotheringham, Nobuo Nagai, Ioan Davies, Lieve Moons, Fredrik Blomstrand, Ulrika Wilhelmsson, Kerstin Larsson, Daniel Andersson, Andrea C. Pardo, Michael Nilsson, Nicholas J. Maragakis, Andrea Lundkvist, Anders Ståhlberg, Takeshi Yabe, Joan P. Schwartz, Milos Pekny, Peter Carmeliet, Mikael Kubista, Marcela Pekna, Lizhen Li, Christina Nodin
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 28:468-481
Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct evidence has been lacking due to the absence of suitable experimental models. Previously, we generated mice deficient in two intermediate filament (IF) proteins
Autor:
John O. Willoughby, I Marita Broberg, Lorraine Mackenzie, Torsten Olsson, Angus Wallace, Kenneth J. Pope, Fredrik Blomstrand, Michael Nilsson
Publikováno v:
Neuroscience. 140:505-515
The cellular processes that take place during the transition from pre-seizure state to seizure remain to be defined. In this study in awake, paralyzed rats, we used an electrical impedance measure of changes in extra-cellular intracranial volume to e
Publikováno v:
Journal of Neurochemistry. 94:1111-1123
Astrocytes are highly coupled by gap junction channels, which allow transfer of intracellular signalling molecules and metabolites between connected cells. Astrocytic gap junctions remain open during ischemic conditions as previously demonstrated in
Autor:
Christine Carlsson-Skwirut, Fredrik Blomstrand, Björn Carlsson, N. David Åberg, Peter S. Eriksson, Peter Bang, Lars Rönnbäck, Maria A I Åberg, Ulrika Björklund
Publikováno v:
Journal of Neuroscience Research. 74:12-22
Connexin43 (cx43) forms gap junctions in astrocytes, and these gap junctions mediate intercellular communication by providing transport of low-molecular-weight metabolites and ions. We have recently shown that systemic growth hormone increases cx43 i
Autor:
Lars Rönnbäck, Louise Allansson, Fredrik Blomstrand, Thorleif Thorlin, Elisabeth Hansson, Michael Nilsson, Jon Sinclair, Håkan Muyderman, Julia Leonova
Publikováno v:
Neurochemistry International. 37:317-329
Astroglia have the capacity to monitor extracellular glutamate (Glu) and maintain it at low levels, metabolize Glu, or release it back into the extracellular space. Glu can induce an increase in astroglial cell volume with a resulting decrease of the