Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Fredrik Almqvist"'
Autor:
Gregory A. Harrison, Erin R. Wang, Kevin Cho, Yassin Mreyoud, Souvik Sarkar, Fredrik Almqvist, Gary J. Patti, Christina L. Stallings
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Of the approximately 10 million cases of Mycobacterium tuberculosis (Mtb) infections each year, over 10% are resistant to the frontline antibiotic isoniazid (INH). INH resistance is predominantly caused by mutations that decrease the activit
Externí odkaz:
https://doaj.org/article/6376d9c665324f819f24fe9e4bf3fa83
Autor:
Hasan Tükenmez, Pardeep Singh, Souvik Sarkar, Melike Çakır, Ana H. Oliveira, Cecilia Lindgren, Karolis Vaitkevicius, Mari Bonde, A. Elisabeth Sauer-Eriksson, Fredrik Almqvist, Jörgen Johansson
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Listeria monocytogenes is a facultative Gram-positive bacterium that causes listeriosis, a severe foodborne disease. We previously discovered that ring-fused 2-pyridone compounds can decrease virulence factor expression in Listeria by bindin
Externí odkaz:
https://doaj.org/article/186a437a48004ee2be0dba97c78a2add
Autor:
Hasan Tükenmez, Souvik Sarkar, Saber Anoosheh, Anastasiia Kruchanova, Isabel Edström, Gregory A. Harrison, Christina L. Stallings, Fredrik Almqvist, Christer Larsson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a major health threat listed among the top 10 causes of death worldwide. Treatment of multidrug-resistant Mtb requires use of additional second-line drugs that prolong the treatmen
Externí odkaz:
https://doaj.org/article/6c9eede13e994821b7d67d8a10ff5bf1
Autor:
Elisabeth Reithuber, Priyanka Nannapaneni, Olena Rzhepishevska, Anders E. G. Lindgren, Oleksandr Ilchenko, Staffan Normark, Fredrik Almqvist, Birgitta Henriques-Normark, Peter Mellroth
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Streptococcus pneumoniae, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci from this niche would reduce the disease burden and could
Externí odkaz:
https://doaj.org/article/37a7655286df455188901d9598d4a006
Autor:
Rachel Kelly, Andrew G. Cairns, Jörgen Ådén, Fredrik Almqvist, Alexis-Pierre Bemelmans, Emmanuel Brouillet, Tommy Patton, Declan P. McKernan, Eilís Dowd
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1685 (2021)
Animal models of Parkinson’s disease, in which the human α-synuclein transgene is overexpressed in the nigrostriatal pathway using viral vectors, are widely considered to be the most relevant models of the human condition. However, although highly
Externí odkaz:
https://doaj.org/article/c447a4e33b7344ddb7f816064af2a6e0
Autor:
Małgorzata Pokrzywa, Katarzyna Pawełek, Weronika Elżbieta Kucia, Szymon Sarbak, Erik Chorell, Fredrik Almqvist, Pernilla Wittung-Stafshede
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184117 (2017)
Alpha-synuclein (aS) amyloid formation is involved in Parkinson's disease (PD); therefore, small molecules that target aS and affect its aggregation are of interest as future drug candidates. We recently reported modified ring-fused 2-pyridones that
Externí odkaz:
https://doaj.org/article/49451c268c3d480387b273e34eb84b9b
Autor:
Mårten Strand, Marcus Carlsson, Hanna Uvell, Koushikul Islam, Karin Edlund, Inger Cullman, Björn Altermark, Ya-Fang Mei, Mikael Elofsson, Nils-Peder Willassen, Göran Wadell, Fredrik Almqvist
Publikováno v:
Marine Drugs, Vol 12, Iss 2, Pp 799-821 (2014)
Adenovirus infections in immunocompromised patients are associated with high mortality rates. Currently, there are no effective anti-adenoviral therapies available. It is well known that actinobacteria can produce secondary metabolites that are attra
Externí odkaz:
https://doaj.org/article/72010b062385473dabc14b481e6f2ccf
Autor:
Carrie L. Shaffer, James A. D. Good, Santosh Kumar, K. Syam Krishnan, Jennifer A. Gaddy, John T. Loh, Joseph Chappell, Fredrik Almqvist, Timothy L. Cover, Maria Hadjifrangiskou
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT Bacteria utilize complex type IV secretion systems (T4SSs) to translocate diverse effector proteins or DNA into target cells. Despite the importance of T4SSs in bacterial pathogenesis, the mechanism by which these translocation machineries d
Externí odkaz:
https://doaj.org/article/15bbd8d36f9e457eba73abb71a8f3410
Autor:
Kyle A Floyd, Jessica L Moore, Allison R Eberly, James A D Good, Carrie L Shaffer, Himesh Zaver, Fredrik Almqvist, Eric P Skaar, Richard M Caprioli, Maria Hadjifrangiskou
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004697 (2015)
Bacterial biofilms account for a significant number of hospital-acquired infections and complicate treatment options, because bacteria within biofilms are generally more tolerant to antibiotic treatment. This resilience is attributed to transient bac
Externí odkaz:
https://doaj.org/article/f0b95e15d2bd4bfaab31f631d21cec41
Autor:
Patrik Engström, K. Syam Krishnan, Bidong D. Ngyuen, Erik Chorell, Johan Normark, Jim Silver, Robert J. Bastidas, Matthew D. Welch, Scott J. Hultgren, Hans Wolf-Watz, Raphael H. Valdivia, Fredrik Almqvist, Sven Bergström
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
ABSTRACT In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120. A fluorescent KSK120 analogue was synthesized and observed to be associated with the
Externí odkaz:
https://doaj.org/article/00303facf7d845949d710878fb025781