Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Fredrik, Rahm"'
Autor:
Mary T. Fletcher, Barry J. Wood, Brett D. Schwartz, Fredrik Rahm, Lynette K. Lambert, Ian D. Brereton, Christopher J. Moore, James J. De Voss, William Kitching
Publikováno v:
ARKIVOC, Vol 2004, Iss 10, Pp 109-117 (2004)
Externí odkaz:
https://doaj.org/article/84b94db0327f48828ebd0a411b43cb4e
Autor:
Britt-Marie Swahn, Ylva Gravenfors, Gunnar Nordvall, Jenny Viklund, Fredrik Rahm, Karin Kolmodin, Mats Svensson
Publikováno v:
ACS Medicinal Chemistry Letters. 5:440-445
In order to find optimal core structures as starting points for lead optimization, a multiparameter lead generation workflow was designed with the goal of finding BACE-1 inhibitors as a treatment for Alzheimer's disease. De novo design of core fragme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885dc56bda6538e85c3fe554c7e2c1f6
https://doi.org/10.1021/ml5000433
https://doi.org/10.1021/ml5000433
Autor:
Patricia Y. Hayes, Fredrik Rahm, James J. De Voss, William Kitching, Brett D. Schwartz, Christopher J. Moore
Publikováno v:
Journal of the American Chemical Society. 130:14853-14860
The volatile components of the mandibular gland secretion generated by the Giant Ichneumon parasitoid wasp Megarhyssa nortoni nortoni Cresson are mainly spiroacetals and methyl ketones, and all have an odd number of carbon atoms. A biosynthetic schem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d8105b204077dc1c5043c7317e33b6
https://doi.org/10.1021/ja8036433
https://doi.org/10.1021/ja8036433
Autor:
Fredrik Rahm, Ulf Bremberg, Laurent Hortala, Guy Quéguiner, Emmanuel Macedo, J. Bourguignon, G. Dupas, Vincent Levacher, Christina Moberg, Kristina Hallman, Serghey Lutsenko, Lars Hagberg
Publikováno v:
Tetrahedron. 59:9583-9589
Chiral pyridinooxazoline, quinolinooxazoline, bis(oxazolino)pyridine (pybox), and bisoxazoline (box) derivatives containing crown ether residues were prepared. Some of the ligands were assessed in substrate binding studies and in palladium catalyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aee182d83bdf449da8e2ea0442a9b530
https://doi.org/10.1016/j.tet.2003.10.005
https://doi.org/10.1016/j.tet.2003.10.005
Autor:
Mátyás Gorjánácz, Ellermann Manuel, Johan Lindström, Lionel Trésaugues, Jörg Weiske, Stefanie Bunse, Martin Andersson, Fredrik Rahm, Anja Giese, Maria Quanz, Tobias Ginman, Roland Neuhaus, Ashley Eheim, Rickard Forsblom, Jenny Viklund, Andrea Glasauer
Publikováno v:
Cancer Research. 77:5226-5226
Malignant transformation is accompanied by increased reactive oxygen species (ROS) known to promote carcinogenesis and damage free nucleotides and DNA. During replication, damaged nucleotides are incorporated into DNA resulting in DNA breaks and muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f14e080e788d6184befeb6321c2efb12
https://doi.org/10.1158/1538-7445.am2017-5226
https://doi.org/10.1158/1538-7445.am2017-5226
Autor:
Fredrik Rahm, Magnus Cernerud, Robert Stranne, Christina Moberg, Emmanuel Macedo, Ulf Bremberg, Kerstin Nordström
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1983-1990
Enantiomerically pure 2-(1-hydroxyalkyl)pyridines were prepared via reaction of 2-lithiopyridine with (R)-2,3-O-isopropylideneglyceraldehyde, methyl (S)-2-methoxypropionate and methyl (S)-2-methoxy-2-phenylacetate, obtained from D-mannitol, L-lactic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6046d2b22d8bd44daff47998beec6a1f
https://doi.org/10.1039/b000269k
https://doi.org/10.1039/b000269k
Publikováno v:
Tetrahedron: Asymmetry. 9:3437-3443
Four new chiral pyridino- and quinolino-oxazolines were subjected to the palladium-catalyzed alkylation of 1,3-diphenyl-2-propenyl acetate. The enantioselectivity varied (82–88% ee) with the steric properties of the ligands. The results are discuss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8f6483e2f148b26cd90bae20d24acc
https://doi.org/10.1016/s0957-4166(98)00346-2
https://doi.org/10.1016/s0957-4166(98)00346-2
Autor:
Jenny Viklund, Ylva Gravenfors, Fredrik Jeppsson, Anders E. G. Lindgren, Anh Johansson, Jonas Malmström, Jan Blid, Karin J. Sterky, Annika Kers, Rickard Forsblom, Rikard Emond, Johanna Fälting, Tobias Ginman, Fredrik Rahm, Patrik Johansson, Margareta Bergh, Fredrik Lake, Fernando Sehgelmeble
Publikováno v:
Journal of medicinal chemistry. 56(11)
By use of iterative design aided by predictive models for target affinity, brain permeability, and hERG activity, novel and diverse compounds based on cyclic amidine and guanidine cores were synthesized with the goal of finding BACE-1 inhibitors as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28939a6aa8f37799fef11079a09af60e
https://pubmed.ncbi.nlm.nih.gov/23126626
https://pubmed.ncbi.nlm.nih.gov/23126626
Autor:
Ylva, Gravenfors, Jenny, Viklund, Jan, Blid, Tobias, Ginman, Sofia, Karlström, Jacob, Kihlström, Karin, Kolmodin, Johan, Lindström, Stefan, von Berg, Fredrik, von Kieseritzky, Krisztian, Bogar, Can, Slivo, Britt-Marie, Swahn, Lise-Lotte, Olsson, Patrik, Johansson, Susanna, Eketjäll, Johanna, Fälting, Fredrik, Jeppsson, Kia, Strömberg, Juliette, Janson, Fredrik, Rahm
Publikováno v:
Journal of medicinal chemistry. 55(21)
Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer’s disease. Synthetic methods, crystal structures, and structure–activity relationships for target activity, permeability, and hERG activity are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e0ec2c24a4566dacbf31db9c6264bc
https://pubmed.ncbi.nlm.nih.gov/23017051
https://pubmed.ncbi.nlm.nih.gov/23017051
Autor:
Patricia Y. Hayes, Paul V. Bernhardt, William Kitching, Sharon Chow, Fredrik Rahm, James J. De Voss
Publikováno v:
The Journal of organic chemistry. 75(19)
The Caribbean sponges of the genus Plakortis, P. halichondrioides, and P. simplex have provided a series of biologically active furanolactones-the plakortones A-D (1-4) from the former sponge and B-F (2-6) from the latter. The defining motif of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f9389b11a3878c786625dfe53c5ef1
https://pubmed.ncbi.nlm.nih.gov/20809656
https://pubmed.ncbi.nlm.nih.gov/20809656