Výsledky vyhledávání - "Fredrik, Öberg"

Akademický článek

PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Autor: Patrick Nylund, Berta Garrido-Zabala, Alba Atienza Párraga, Louella Vasquez, Paul Theodor Pyl, George Mickhael Harinck, Anqi Ma, Jian Jin, Fredrik Öberg, Antonia Kalushkova, Helena Jernberg Wiklund

Publikováno v: Haematologica, Vol 109, Iss 2 (2023)

Multiple myeloma is a heterogeneous hematological disease that originates from the bone marrow and is characterized by the monoclonal expansion of malignant plasma cells. Despite novel therapies, multiple myeloma remains clinically challenging. A com

Externí odkaz: https://doaj.org/article/54d146f1cd6c4084ae909eaf599b99d0

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Akademický článek

A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Autor: Patrick Nylund, Alba Atienza Párraga, Jakob Haglöf, Elke De Bruyne, Eline Menu, Berta Garrido-Zabala, Anqi Ma, Jian Jin, Fredrik Öberg, Karin Vanderkerken, Antonia Kalushkova, Helena Jernberg-Wiklund

Publikováno v: Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)

Abstract Multiple myeloma (MM) is a heterogeneous haematological disease that remains clinically challenging. Increased activity of the epigenetic silencer EZH2 is a common feature in patients with poor prognosis. Previous findings have demonstrated

Externí odkaz: https://doaj.org/article/102657295ae543ceae01381242f3b978

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Akademický článek

The Endothelin Receptor Antagonist Macitentan Inhibits Human Cytomegalovirus Infection

Autor: Natalia Landázuri, Jennifer Gorwood, Ylva Terelius, Fredrik Öberg, Koon Chu Yaiw, Afsar Rahbar, Cecilia Söderberg-Nauclér

Publikováno v: Cells, Vol 10, Iss 11, p 3072 (2021)

Human cytomegalovirus (HCMV) infection is an important cause of morbidity and mortality in immunocompromised patients and a major etiological factor for congenital birth defects in newborns. Ganciclovir and its pro-drug valganciclovir are the preferr

Externí odkaz: https://doaj.org/article/b455b9d8327b4176a0cfab58dc3d66cf

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Akademický článek

Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways.

Autor: Philip Kitchen, Fredrik Öberg, Jennie Sjöhamn, Kristina Hedfalk, Roslyn M Bill, Alex C Conner, Matthew T Conner, Susanna Törnroth-Horsefield

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143027 (2015)

Aquaporin membrane protein channels mediate cellular water flow. Human aquaporin 5 (AQP5) is highly expressed in the respiratory system and secretory glands where it facilitates the osmotically-driven generation of pulmonary secretions, saliva, sweat

Externí odkaz: https://doaj.org/article/999e92a6256e47d0a85df8d89f6d84c8

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Symptomatic and structural benefit of cathepsin K inhibition by MIV-711 in a subgroup with unilateral pain: post-hoc analysis of a randomised phase 2a clinical trial

Autor: Asger Reinstrup, Bihlet, Inger, Byrjalsen, Jeppe Ragnar, Andersen, Fredrik, Öberg, Christina, Herder, Mike A, Bowes, Philip G, Conaghan

Publikováno v: Clinical and experimental rheumatology. 40(5)

Osteoarthritis (OA) development programmes face challenges due to discordance between structural changes and symptoms. A novel cathepsin-K inhibitor, MIV-711, recently reported structural benefits, but did not demonstrate a significant difference fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4dcbf811164cf668c9aafc44de568d0
https://pubmed.ncbi.nlm.nih.gov/35238765

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A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Autor: Fredrik Öberg, Elke De Bruyne, Antonia Kalushkova, Eline Menu, Jakob Haglöf, Helena Jernberg-Wiklund, Berta Garrido-Zabala, Alba Atienza Párraga, Karin Vanderkerken, Anqi Ma, Patrick Nylund, Jian Jin

Publikováno v: Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Cell Death & Disease

Multiple myeloma (MM) is a heterogeneous haematological disease that remains clinically challenging. Increased activity of the epigenetic silencer EZH2 is a common feature in patients with poor prognosis. Previous findings have demonstrated that meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d83db95730eadda91d9fa2550ab9ed8
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-434805

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Phase I study of the novel pro-drug MIV-818 in patients with hepatocellular carcinoma, intra-hepatic cholangiocarcinoma or liver metastases

Autor: Hans Prenen, Linda Basse, Debashis Sarker, Eric Van Cutsem, Fredrik Öberg, Elizabeth Ruth Plummer, Karin Tunblad, T.R. Jeffry Evans, Thomas Morris, Mark R. Middleton

Publikováno v: Journal of Clinical Oncology. 39:309-309

309 Background: MIV-818 is an orally administered troxacitabine (TRX)-based nucleotide prodrug. It is highly metabolized by human hepatocytes, directing high levels of the chain-terminating nucleotide tri-phosphate to the liver, while minimizing expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::589ad286659fefc1d75d44908f207e64
https://doi.org/10.1200/jco.2021.39.3_suppl.309

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