Zobrazeno 1 - 10 of 282 pro vyhledávání: '"Fredrick M, Wigley"'
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Akademický článek
Linaclotide for the treatment of refractory lower bowel manifestations of systemic sclerosis
Autor: Eric J. Dein, Fredrick M. Wigley, Zsuzsanna H. McMahan
Publikováno v: BMC Gastroenterology, Vol 21, Iss 1, Pp 1-6 (2021)
Abstract Background Lower gastrointestinal (GI) tract involvement can affect up to 50% of systemic sclerosis (SSc) patients, and may result in malabsorption, pseudo-obstruction, hospitalization, and death. We report our experience with linaclotide, a
Externí odkaz: https://doaj.org/article/9e0f37b5c2e04c608be88aa1fb6b493f
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2
Slow Colonic Transit in Systemic Sclerosis: An Objective Assessment of Risk Factors and Clinical Phenotype
Autor: Pankaj J. Pasricha, Zsuzsanna H. McMahan, Fredrick M. Wigley, Laura K. Hummers, Elizabeth R. Volkmann, Jamie Perin, Jenice X Cheah
Publikováno v: Arthritis Care Res (Hoboken)
Up to 50% of patients with systemic sclerosis (SSc) experience slow colonic transit, which may be associated with severe outcomes. Our objective, therefore, was to identify specific clinical features associated with slow colonic transit in SSc.SSc pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88826dd39d77ded498a570f60c18a2b1
https://doi.org/10.1002/acr.24767
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3
Relationship Between Gastrointestinal Transit, Medsger Gastrointestinal Severity, and University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 Symptoms in Patients With Systemic Sclerosis
Autor: Jamie Perin, Harvey A. Ziessman, Zsuzsanna H. McMahan, Fredrick M. Wigley, Ana Elizabeth Tucker, Pankaj J. Pasricha, Elizabeth R. Volkmann, Subhash Kulkarni
Publikováno v: Arthritis Care Res (Hoboken)
Systemic sclerosis (SSc)-associated gastrointestinal (GI) complications are attributed to a variety of factors, including diet, microbiota dysbiosis, or GI transit abnormalities. Our objective was to examine the contribution of abnormal GI transit to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e303b2488cb6d0a9755a1bd7fb638b58
https://doi.org/10.1002/acr.24488
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4
Cumulative disease damage and anti-PM/Scl antibodies are associated with a heavy burden of calcinosis in systemic sclerosis
Autor: Carrie Richardson, Jamie Perin, Scott Zeger, Fredrick M Wigley, Laura K Hummers, Livia Casciola-Rosen, Antony Rosen, Ami A Shah
Publikováno v: Rheumatology.
Objectives Ectopic calcification (calcinosis) is a common complication of SSc, but a subset of SSc patients has a heavy burden of calcinosis. We examined whether there are unique risk factors for a heavy burden of calcinosis, as compared with a light
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4f0f98dcf84ef5e412fcaaba1ce6ac
https://doi.org/10.1093/rheumatology/keac682
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6
Assessment of right ventricular reserve utilizing exercise provocation in systemic sclerosis
Autor: Fredrick M. Wigley, Ami A. Shah, Susan A. Mayer, Steven Hsu, Monica Mukherjee, Valentina Mercurio, Paul M. Hassoun, Laura K. Hummers, David A. Kass, Ryan J. Tedford, Stephen C. Mathai
Publikováno v: Int J Cardiovasc Imaging
PURPOSE: Right ventricular (RV) capacity to adapt to increased afterload is the main determinant of outcome in pulmonary hypertension (PH), a common morbidity seen in systemic sclerosis (SSc). We hypothesized that supine bicycle echocardiography (SBE
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270095062502e210c8fee5daa8aec83e
https://doi.org/10.1007/s10554-021-02237-9
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Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma
Autor: Ami A. Shah, Eleni Tiniakou, Francesco Boin, Robert N. O'Meally, Fredrick M. Wigley, Tara Guhr, Erika Darrah, Zsuzsanna H. McMahan, Andrea Fava, Robert N. Cole
Publikováno v: Arthritis & rheumatology (Hoboken, N.J.), vol 72, iss 8
Arthritis Rheumatol
Author(s): Tiniakou, Eleni; Fava, Andrea; McMahan, Zsuzsanna H; Guhr, Tara; O'Meally, Robert N; Shah, Ami A; Wigley, Fredrick M; Cole, Robert N; Boin, Francesco; Darrah, Erika | Abstract: ObjectiveAutoimmune responses to DNA topoisomerase I (topo I)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed3dfc08e486ca322b94e9ee1c5e276
https://doi.org/10.1002/art.41248
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HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry
Autor: Reem Kais Jan, Daniel L. Kastner, Francesco Boin, Chris T. Derk, Kathleen D. Kolstad, Vivien Hsu, Heather Gladue, Virginia D. Steen, Avram Goldberg, Paula S. Ramos, Victoria K. Shanmugam, Dinesh Khanna, Lorinda Chung, Ayo P. Doumatey, Richard M. Silver, Elana J. Bernstein, Amy R. Bentley, Pravitt Gourh, Nadia D. Morgan, Ami A. Shah, Maureen D. Mayes, Lesley Ann Saketkoo, Fredrick M. Wigley, Steven E. Boyden, Brynn Kron, Elena Schiopu, Benjamin D. Korman, Lindsey A. Criswell, Peter J. Steinbach, S. Louis Bridges, Suzanne Kafaja, Thomas A. Medsger, Daniel Shriner, James C. Mullikin, Settara C. Chandrasekharappa, Jessica K. Gordon, Robyn T. Domsic, Elaine F. Remmers, John Varga, Adebowale Adeyemo, Sarah A. Safran, Theresa Alexander, Marcin Trojanowski, Charles N. Rotimi
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 1
Significance HLA alleles have previously been implicated with scleroderma risk, but, in this study, using a European American ancestral cohort and a newly recruited large cohort of African Americans, we comprehensively define the HLA alleles and amin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a93c337973c75c6b198b9d9bb23399b
https://doi.org/10.1073/pnas.1906593116
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Vascular biomarkers and digital ulcerations in systemic sclerosis: results from a randomized controlled trial of oral treprostinil (DISTOL-1)
Autor: Ami A. Shah, Jennifer E. Van Eyk, Andrew G. Allmon, Jamie Perin, Christopher A. Mecoli, Youlan Rao, Jie Zhu, Qin Fu, Fredrick M. Wigley, Laura K. Hummers, Scott L. Zeger
Publikováno v: Clin Rheumatol
Although there is abundant evidence of vascular perturbation from studies of peripheral blood in systemic sclerosis (SSc), there are few data about the ability to use biomarkers of vascular injury and growth factors to predict vascular outcomes and r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1970ce07a93e95e3761da5fe49bf92ee
https://doi.org/10.1007/s10067-019-04863-0
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10
Diastolic Dysfunction in Systemic Sclerosis: Risk Factors and Impact on Mortality
Autor: Alicia M. Hinze, Jamie Perin, Adrianne Woods, Laura K. Hummers, Fredrick M. Wigley, Monica Mukherjee, Ami A. Shah
Publikováno v: Arthritis Rheumatol
To determine the independent risk factors for diastolic dysfunction (DD) in patients with systemic sclerosis (SSc) and to evaluate the impact of DD on mortality.SSc patients enrolled in the Johns Hopkins Scleroderma Center Cohort between November 1,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e76825d523cd4f26536de4ca00dd32
https://pubmed.ncbi.nlm.nih.gov/34927390
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