Linaclotide for the treatment of refractory lower bowel manifestations of systemic sclerosis

Autor: Eric J. Dein, Fredrick M. Wigley, Zsuzsanna H. McMahan

Publikováno v: BMC Gastroenterology, Vol 21, Iss 1, Pp 1-6 (2021)

Abstract Background Lower gastrointestinal (GI) tract involvement can affect up to 50% of systemic sclerosis (SSc) patients, and may result in malabsorption, pseudo-obstruction, hospitalization, and death. We report our experience with linaclotide, a

Externí odkaz: https://doaj.org/article/9e0f37b5c2e04c608be88aa1fb6b493f

Relationship Between Gastrointestinal Transit, Medsger Gastrointestinal Severity, and University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 Symptoms in Patients With Systemic Sclerosis

Autor: Jamie Perin, Harvey A. Ziessman, Zsuzsanna H. McMahan, Fredrick M. Wigley, Ana Elizabeth Tucker, Pankaj J. Pasricha, Elizabeth R. Volkmann, Subhash Kulkarni

Publikováno v: Arthritis Care Res (Hoboken)

Systemic sclerosis (SSc)-associated gastrointestinal (GI) complications are attributed to a variety of factors, including diet, microbiota dysbiosis, or GI transit abnormalities. Our objective was to examine the contribution of abnormal GI transit to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e303b2488cb6d0a9755a1bd7fb638b58
https://doi.org/10.1002/acr.24488

Cumulative disease damage and anti-PM/Scl antibodies are associated with a heavy burden of calcinosis in systemic sclerosis

Autor: Carrie Richardson, Jamie Perin, Scott Zeger, Fredrick M Wigley, Laura K Hummers, Livia Casciola-Rosen, Antony Rosen, Ami A Shah

Publikováno v: Rheumatology.

Objectives Ectopic calcification (calcinosis) is a common complication of SSc, but a subset of SSc patients has a heavy burden of calcinosis. We examined whether there are unique risk factors for a heavy burden of calcinosis, as compared with a light

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4f0f98dcf84ef5e412fcaaba1ce6ac
https://doi.org/10.1093/rheumatology/keac682

Assessment of right ventricular reserve utilizing exercise provocation in systemic sclerosis

Autor: Fredrick M. Wigley, Ami A. Shah, Susan A. Mayer, Steven Hsu, Monica Mukherjee, Valentina Mercurio, Paul M. Hassoun, Laura K. Hummers, David A. Kass, Ryan J. Tedford, Stephen C. Mathai

Publikováno v: Int J Cardiovasc Imaging

PURPOSE: Right ventricular (RV) capacity to adapt to increased afterload is the main determinant of outcome in pulmonary hypertension (PH), a common morbidity seen in systemic sclerosis (SSc). We hypothesized that supine bicycle echocardiography (SBE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270095062502e210c8fee5daa8aec83e
https://doi.org/10.1007/s10554-021-02237-9

HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry

Autor: Reem Kais Jan, Daniel L. Kastner, Francesco Boin, Chris T. Derk, Kathleen D. Kolstad, Vivien Hsu, Heather Gladue, Virginia D. Steen, Avram Goldberg, Paula S. Ramos, Victoria K. Shanmugam, Dinesh Khanna, Lorinda Chung, Ayo P. Doumatey, Richard M. Silver, Elana J. Bernstein, Amy R. Bentley, Pravitt Gourh, Nadia D. Morgan, Ami A. Shah, Maureen D. Mayes, Lesley Ann Saketkoo, Fredrick M. Wigley, Steven E. Boyden, Brynn Kron, Elena Schiopu, Benjamin D. Korman, Lindsey A. Criswell, Peter J. Steinbach, S. Louis Bridges, Suzanne Kafaja, Thomas A. Medsger, Daniel Shriner, James C. Mullikin, Settara C. Chandrasekharappa, Jessica K. Gordon, Robyn T. Domsic, Elaine F. Remmers, John Varga, Adebowale Adeyemo, Sarah A. Safran, Theresa Alexander, Marcin Trojanowski, Charles N. Rotimi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 1

Significance HLA alleles have previously been implicated with scleroderma risk, but, in this study, using a European American ancestral cohort and a newly recruited large cohort of African Americans, we comprehensively define the HLA alleles and amin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a93c337973c75c6b198b9d9bb23399b
https://doi.org/10.1073/pnas.1906593116