Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Fredrick M, Pavalko"'
Autor:
Whitney A. Bullock, April M. Hoggatt, Daniel J. Horan, Andrew J. Elmendorf, Amy Y. Sato, Teresita Bellido, Gabriela G. Loots, Fredrick M. Pavalko, Alexander G. Robling
Publikováno v:
iScience, Vol 20, Iss , Pp 205-215 (2019)
Summary: Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4
Externí odkaz:
https://doaj.org/article/f7f843d78c6348eabf7967aba03f1a68
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0261660 (2021)
Earlier, we proposed the "mechanosome" concept as a testable model for understanding how mechanical stimuli detected by cell surface adhesion molecules are transmitted to modulate gene expression inside cells. Here, for the first time we document a p
Externí odkaz:
https://doaj.org/article/bf366e23195d4d51b775dfc2964482c9
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 11, Pp 14385-14400 (2012)
Live-cell microscopy is now routinely used to monitor the activities of the genetically encoded biosensor proteins that are designed to directly measure specific cell signaling events inside cells, tissues, or organisms. Most fluorescent biosensor pr
Externí odkaz:
https://doaj.org/article/9c004a00efe94ed2b3467abeb6a8fb02
Publikováno v:
BioTechniques, Vol 39, Iss 6, Pp 826-832 (2005)
Externí odkaz:
https://doaj.org/article/fd690f87153f439da01b768c47a70e3f
Autor:
Teresita Bellido, Alexander G. Robling, April M. Hoggatt, Andrew J. Elmendorf, Daniel J. Horan, Amy Y. Sato, Fredrick M. Pavalko, Gabriela G. Loots, Whitney A. Bullock
Publikováno v:
iScience
iScience, Vol 20, Iss, Pp 205-215 (2019)
iScience, Vol 20, Iss, Pp 205-215 (2019)
Summary Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757117d28677e2fd29c8eb31b422eb41
http://europepmc.org/articles/PMC6817631
http://europepmc.org/articles/PMC6817631
Autor:
Daniel J. Horan, April M. Hoggatt, Hiroki Yokota, Fredrick M. Pavalko, Alexander G. Robling, Whitney A. Bullock, Karl J. Lewis, Steven Hann, Matthew L. Warman, Gabriela G. Loots, Aimy Sebastian
Publikováno v:
J Bone Miner Res
Mechanical stimulation is a key regulator of bone mass, maintenance, and turnover. Wnt signaling is a key regulator of mechanotransduction in bone, but the role of β-catenin-an intracellular signaling node in the canonical Wnt pathway-in disuse mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9447b85ff3cffdce2ca1d0fefdd85aa4
https://doi.org/10.1002/jbmr.3812
https://doi.org/10.1002/jbmr.3812
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97942 (2014)
Mechanical stimulation of the skeleton promotes bone gain and suppresses bone loss, ultimately resulting in improved bone strength and fracture resistance. The molecular mechanisms directing anabolic and/or anti-catabolic actions on the skeleton duri
Externí odkaz:
https://doaj.org/article/6a79d8f376e54e6c917e0bd8d0f85a5f
Autor:
Fredrick M. Pavalko, Richard O. Day, Raghavendra G. Mirmira, Christopher A. Reissaus, Kathleen H. Day, Kenneth W. Dunn
Publikováno v:
Biophys J
We report the use of pulsed interleaved excitation-fluorescence lifetime imaging microscopy (PIE-FLIM) to measure the activities of two different biosensor probes simultaneously in single living cells. Many genetically encoded biosensors rely on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b320370581b80316e569aa3a5277f1bd
https://doi.org/10.1101/2020.01.10.902213
https://doi.org/10.1101/2020.01.10.902213
Publikováno v:
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9877090cbdfa6a1a8d19f83aa4c53cb
https://doi.org/10.1002/9781119266594.ch10
https://doi.org/10.1002/9781119266594.ch10
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16026 (2011)
Mechanotransduction, the process by which cells convert external mechanical stimuli such as fluid shear stress (FSS) into biochemical changes, plays a critical role in maintenance of the skeleton. We have proposed that mechanical stimulation by FSS a
Externí odkaz:
https://doaj.org/article/f1d1eb90c3ba43e8a8e640a4b1f8fa0b