Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Fredrick G. Karnell"'
Autor:
Samantha Motley, Laurence A. Turka, Dongxia Lin, Kristina M. Harris, Noha Lim, Holden T. Maecker, Thomas Duhen, Fredrick G. Karnell, Daniel J. Campbell
Summary Multiple sclerosis is an inflammatory T cell-mediated autoimmune disease. In a Phase II clinical trial, high-dose immunosuppressive therapy combined with autologous CD34+ haematopoietic stem cell transplant resulted in 69·2% of subjects rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc20ec6851ab3011197d5782a7b3c70
https://europepmc.org/articles/PMC5543487/
https://europepmc.org/articles/PMC5543487/
Autor:
Rachel Ettinger, Raphaela Goldbach-Mansky, Chris Morehouse, Bonnie Swerdlow, Ronald Herbst, Mildred Wilson, Ying Li, Bhargavi Rajan, Geoffrey L. Stephens, Anthony J. Coyle, Christopher Groves, Fredrick G. Karnell, Jodi L. Karnell
Publikováno v:
The Journal of Immunology. 187:3603-3612
Production of pathogenic Abs contributes to disease progression in many autoimmune disorders. The immunosuppressant agent mycophenolic acid (MPA) has shown clinical efficacy for patients with autoimmunity. The goal of these studies was to elucidate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd8f2f6982d6a50c1bfc94d6dd5df37
https://doi.org/10.4049/jimmunol.1003319
https://doi.org/10.4049/jimmunol.1003319
Autor:
Laura S. Treml, Fredrick G. Karnell, Kimberly A. Jordan, William J. Quinn, John G. Monroe, Michael P. Cancro, Mary Kaileh, Juli P. Miller, Jean L. Scholz, Randall J. Brezski, Ranjan Sen, Jason Stadanlick
Publikováno v:
Nature Immunology. 9:1379-1387
The survival of transitional and mature B cells requires both the B cell antigen receptor (BCR) and BLyS receptor 3 (BR3), which suggests that these receptors send signals that are nonredundant or that engage in crosstalk with each other. Here we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec1e85319d0b8afbd9c9aa562cdba4d
https://doi.org/10.1038/ni.1666
https://doi.org/10.1038/ni.1666
Autor:
John G. Monroe, Fredrick G. Karnell
Publikováno v:
Transfusion Medicine and Hemotherapy. 33:8-17
Engagement of immune receptors by antigen triggers processes that culminate in activation, cell proliferation, differentiation and effector functions. A growing body of evidence suggests that it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd3e161ec9a3545b30a2fae80c475e73
https://doi.org/10.1159/000090192
https://doi.org/10.1159/000090192
Autor:
Lanwei Xu, Warren S. Pear, Yiping He, Ruibao Ren, Jason A. Wertheim, Fredrick G. Karnell, John K. Choi, Juli P. Miller
Publikováno v:
Blood. 99:2957-2968
The bcr/abl fusion in chronic myelogenous leukemia (CML) creates a chimeric tyrosine kinase with dramatically different properties than intact c-abl. In P210 bcr/abl, the bcr portion includes a coiled-coil oligomerization domain (amino acids 1-63) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27773dfd00ec324249250753cc554065
https://doi.org/10.1182/blood.v99.8.2957
https://doi.org/10.1182/blood.v99.8.2957
Autor:
Vytas Patriub, Lanwei Xu, Jon C. Aster, Yiping He, David J Izon, Carlos G. Rodriguez, Warren S. Pear, Fredrick G. Karnell, David Allman, Sonia Bakkour, Andrew P. Weng
Publikováno v:
Immunity. 16(2):231-243
Notch1 signaling drives T cell development at the expense of B cell development from a common precursor, an effect that is dependent on a C-terminal Notch1 transcriptional activation domain. The function of Deltex1, initially identified as a positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591b862867f474c5b5d66cc51997bca3
Autor:
Ronald Herbst, Rachel Ettinger, Ellen Kuta, Nazzareno Dimasi, Changshou Gao, Jodi L. Karnell, Ryan Fleming, Herren Wu, Mildred Wilson, Fredrick G. Karnell
B cell activation is regulated by a variety of signals. CD19 positively regulates B cell activation, augmenting signals delivered through the BCR complex. In contrast, CD32b contains an ITIM and negatively regulates BCR signaling. Importantly, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ad3f5393597c6c9aab78440648af19
https://europepmc.org/articles/PMC3918864/
https://europepmc.org/articles/PMC3918864/
Autor:
Fredrick G. Karnell, Lanwei Xu, John C. Pui, Jon C. Aster, Jennifer A. Punt, Warren S. Pear, David Allman, Peggy Myung, Sonia Bakkour, Gary A. Koretzky
Publikováno v:
The Journal of Experimental Medicine
Notch1 signaling is required for T cell development. We have previously demonstrated that expression of a dominant active Notch1 (ICN1) transgene in hematopoietic stem cells (HSCs) leads to thymic-independent development of CD4(+)CD8(+) double-positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54325093c67c64066c4a9ddf9fbcea9
https://doi.org/10.1084/jem.194.1.99
https://doi.org/10.1084/jem.194.1.99
Autor:
Fredrick G. Karnell, Bayard D. Clarkson, Mingming Zhao, Warren S. Pear, Masaru Niki, Antonio Di Cristofano, Linda Van Aelst, Pier Paolo Pandolfi
Publikováno v:
The Journal of Experimental Medicine
p62(dok) has been identified as a substrate of many oncogenic tyrosine kinases such as the chronic myelogenous leukemia (CML) chimeric p210(bcr-abl) oncoprotein. It is also phosphorylated upon activation of many receptors and cytoplamic tyrosine kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b80da1e2f06ac8b59231e12906831d4
http://europepmc.org/articles/PMC2193466
http://europepmc.org/articles/PMC2193466
Autor:
Julia Y Lee, Lanwei Xu, Warren S. Pear, John C. Pui, Fredrick G. Karnell, Richard R. Hardy, Susan DeRocco, Tom Kadesch, Sonia Bakkour, Jon C. Aster, David Allman
Publikováno v:
Immunity. 11(3):299-308
Notch receptors regulate fate decisions in many cells. One outcome of Notch signaling is differentiation of bipotential precursors into one cell type versus another. To investigate consequences of Notch1 expression in hematolymphoid progenitors, mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fa85c2431ef977c4047b57e85d1e7c