Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Frederique Ruf-Zamojski"'
Autor:
Xingyu Wang, Jianming Chen, Sachiko T. Homma, Yinhang Wang, Gregory R. Smith, Frederique Ruf-Zamojski, Stuart C. Sealfon, Lan Zhou
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105775- (2023)
Summary: Fibrosis is a prominent pathological feature of skeletal muscle in Duchenne muscular dystrophy (DMD). The commonly used disease mouse model, mdx5cv, displays progressive fibrosis in the diaphragm but not limb muscles. We use single-cell RNA
Externí odkaz:
https://doaj.org/article/4412f7facc8644ebaef67414ff1e5bba
Autor:
Frederique Ruf-Zamojski, Zidong Zhang, Michel Zamojski, Gregory R. Smith, Natalia Mendelev, Hanqing Liu, German Nudelman, Mika Moriwaki, Hanna Pincas, Rosa Gomez Castanon, Venugopalan D. Nair, Nitish Seenarine, Mary Anne S. Amper, Xiang Zhou, Luisina Ongaro, Chirine Toufaily, Gauthier Schang, Joseph R. Nery, Anna Bartlett, Andrew Aldridge, Nimisha Jain, Gwen V. Childs, Olga G. Troyanskaya, Joseph R. Ecker, Judith L. Turgeon, Corrine K. Welt, Daniel J. Bernard, Stuart C. Sealfon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The pituitary gland plays important roles in the regulation of key physiological functions. Here the authors provide a multiomics atlas including transcriptome, chromatin accessibility, and methylation status of over 70,000 single nuclei (sn) from mo
Externí odkaz:
https://doaj.org/article/c782850ef40d4c03ac0d69ac797d06d6
Autor:
Natalia Mendelev, Michel Zamojski, Mary Anne S. Amper, Wan Sze Cheng, Hanna Pincas, Venugopalan D. Nair, Elena Zaslavsky, Stuart C. Sealfon, Frederique Ruf-Zamojski
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101446- (2022)
Summary: Concomitant profiling of transcriptome and chromatin accessibility in isolated nuclei can reveal gene regulatory control mechanisms in health and disease. We report a single nucleus multi-omics analysis protocol optimized for frozen archived
Externí odkaz:
https://doaj.org/article/a3a9214cfbe7450d9f5f76742d262703
Autor:
Zidong Zhang, Michel Zamojski, Gregory R. Smith, Thea L. Willis, Val Yianni, Natalia Mendelev, Hanna Pincas, Nitish Seenarine, Mary Anne S. Amper, Mital Vasoya, Wan Sze Cheng, Elena Zaslavsky, Venugopalan D. Nair, Judith L. Turgeon, Daniel J. Bernard, Olga G. Troyanskaya, Cynthia L. Andoniadou, Stuart C. Sealfon, Frederique Ruf-Zamojski
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110467- (2022)
Summary: Despite their importance in tissue homeostasis and renewal, human pituitary stem cells (PSCs) are incompletely characterized. We describe a human single nucleus RNA-seq and ATAC-seq resource from pediatric, adult, and aged postmortem pituita
Externí odkaz:
https://doaj.org/article/9778f6fbae6c4b3ebc1fa18a2a9f30e3
Autor:
Bingyao Wang, Gregory Smith, Frederique Ruf-Zamojski, Gyu Ho Lee, Stuart C. Sealfon, Jeanine Albu, Susan K. Fried, Kalypso Karastergiou
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 4-5 (2021)
ABSTRACT IMPACT: Characterizing the cellular composition of human adipose tissue may contribute to the prevention and/or treatment of obesity-associated metabolic diseases. OBJECTIVES/GOALS: Our aims in this study were to use single-cell techniques 1
Externí odkaz:
https://doaj.org/article/99f4f226a40444b284a265ad9074b417
Autor:
Frederique Ruf-Zamojski, Miguel Fribourg, Yongchao Ge, Venugopalan Nair, Hanna Pincas, Elena Zaslavsky, German Nudelman, Stephanie J. Tuminello, Hideo Watanabe, Judith L. Turgeon, Stuart C. Sealfon
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
The LβT2 mouse pituitary cell line has many characteristics of a mature gonadotrope and is a widely used model system for studying the developmental processes and the response to gonadotropin-releasing hormone (GnRH). The global epigenetic landscape
Externí odkaz:
https://doaj.org/article/06959d9bfe0c4ef58f0b50a6da035dc6
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128944 (2015)
Dystrophin (Dmd) is a structural protein that links the extracellular matrix to actin filaments in muscle fibers and is required for the maintenance of muscles integrity. Mutations in Dmd lead to muscular dystrophies in humans and other vertebrates.
Externí odkaz:
https://doaj.org/article/e8f244cf36064d7584c35eb5b60a27d7
Autor:
Keiko Taniguchi, Alejandra Chavez-Santoscoy, Silvia Hinojosa-Alvarez, Jesus Hernandez-Perez, Alejandra Valenzuela-Perez, Patino Sandra Vela, Sergio Andonegui-Elguera, Amayrani Cano-Zaragoza, Florencia Martinez, Jacobo Kerbel, Zidong Zhang, Gergory Smith, Aliza Rubenstein, Cheng Wan Sze, Natalia Mendelev, Amper Mary Anne, Michel Zamojski, Elena Zaslavsky, Frederique Ruf-Zamojski, Stuart Sealfon, Moises Mercado, Daniel Marrero-Rodriguez
Publikováno v:
Endocrine Abstracts.
Autor:
Carlos A I Alonso, Caroline D David, Chirine Toufaily, Ying Wang, Xiang Zhou, Luisina Ongaro, German Nudelman, Venugopalan D Nair, Frederique Ruf-Zamojski, Ulrich Boehm, Stuart C Sealfon, Daniel J Bernard
Publikováno v:
Endocrinology. 164
Follicle-stimulating hormone (FSH), a dimeric glycoprotein produced by pituitary gonadotrope cells, regulates spermatogenesis in males and ovarian follicle growth in females. Hypothalamic gonadotropin-releasing hormone (GnRH) stimulates FSHβ subunit
Autor:
Xi Chen, Yuan Wang, Antonio Cappuccio, Wan-Sze Cheng, Frederique Ruf Zamojski, Venugopalan Nair, Clare M Miller, Aliza Rubenstein, German Nudelman, Alicja Tadych, Chandra Theesfeld, Alexandria Vornholt, Mary-Catherine George, Felicia Ruffin, Michael Dagher, Daniel Chawla, Alessandra Soares-Schanoski, Rachel R. Spurbeck, Lishomwa C. Ndhlovu, Robert Sebra, Steven Kleinstein, Andrew G. Letizia, Irene Ramos, Vance G. Fowler, Christopher W. Woods, Elena Zaslavsky, Olga G. Troyanskaya, Stuart C. Sealfon
Resolving chromatin remodeling-linked gene expression changes at cell type resolution is important for understanding disease states. We describe MAGICAL, a hierarchical Bayesian approach that leverages paired scRNA-seq and scATAC-seq data from differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4b6409d47e7ea718daa8221b0727a1a
https://doi.org/10.1101/2022.12.06.22282077
https://doi.org/10.1101/2022.12.06.22282077