Výsledky vyhledávání - "Frederique Martin"

Synthesis and biological evaluation of chalcone-polyamine conjugates as novel vectorized agents in colorectal and prostate cancer chemotherapy

Autor: Christelle Pouget, Aline Pinon, Aurélie Gamond, Benjamin Rioux, Catherine Fagnère, Caroline Barette, Aurélie Laurent, Vincent Sol, Bertrand Liagre, Yves Champavier, Frederique Martin

Publikováno v: European Journal of Medicinal Chemistry. 222:113586

The aim of this study was to synthesize chalcone-polyamine conjugates in order to enhance bioavailability and selectivity of chalcone core towards cancer cells, using polyamine-based vectors. Indeed, it is well-known that polyamine transport system i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db18e0c15f0f1374423afffa6caeef03
https://doi.org/10.1016/j.ejmech.2021.113586

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New selective cyclooxygenase-2 inhibitors from cyclocoumarol: Synthesis, characterization, biological evaluation and molecular modeling

Autor: Anita Marie Rayar, Florent Blanchard, Matthieu Montes, Maité Sylla-Iyarreta Veitía, Nathalie Lagarde, Jean-François Zagury, Clotilde Ferroud, Bertrand Liagre, Frederique Martin

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 146, pp.577-587. ⟨10.1016/j.ejmech.2018.01.054⟩

International audience; In this work, a serie of cyclocoumarol derivatives was designed, synthesized, characterized and studied for their potentialities as selective inhibitors of COX-2. All target compounds have been screened for their anti-inflamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c0b13b5e4b31e5f08b3b16d481a3ed
https://hal.archives-ouvertes.fr/hal-02453627

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Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells

Autor: Frederique Martin, Lama Hassan, Bassam Badran, Bertrand Liagre, Alain Simon, Josiane Seeman, Chloë Fidanzi-Dugas, Aline Pinon, Youness Limami

Publikováno v: Experimental cell research. 345(1)

Melanoma is one of the most aggressive forms of cancer with a continuously growing incidence worldwide and is usually resistant to chemotherapy agents, which is due in part to a strong resistance to apoptosis. Previously, we had showed that B16-F0 mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa935656a2deebc814b6c617b140028
https://pubmed.ncbi.nlm.nih.gov/27262506

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Berberis libanotica extract targets NF-κB/COX-2, PI3K/Akt and mitochondrial/caspase signalling to induce human erythroleukemia cell apoptosis

Autor: Vincent Sol, Mona Diab-Assaf, Antoine M. Saab, Fadi Esseily, Frederique Martin, Saada Diab, Lamia Ghezali, David Yannick Leger, Rania Azar, Chloe Fidanzi, Bertrand Liagre, Marion Millot

Publikováno v: International Journal of Oncology
International Journal of Oncology, Spandidos Publications, 2015, 47 (1), pp.220-230. ⟨10.3892/ijo.2015.3012⟩

International audience; The aim of this study was to describe and understand the relationship between cyclooxygenase-2 (COX-2) expression and apoptosis rate in erythroleukemia cells after apoptosis induction by Berberis libanotica (Bl) extract. To ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a44dfeb31b3dfdbe8791aa7d167820
https://hal.archives-ouvertes.fr/hal-01200642

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Novel methylsulfonyl chalcones as potential antiproliferative drugs for human prostate cancer: involvement of the intrinsic pathway of apoptosis

Autor: Frederique Martin, Christelle Pouget, Bassel Ismail, Rokhaya Gueye, David Yannick Leger, Youness Limami, Jean-Louis Beneytout, Lamia Ghezali, Mona Diab-Assaf, Bertrand Liagre, Catherine Fagnère, Jean-Luc Duroux

Publikováno v: International Journal of Oncology
International Journal of Oncology, Spandidos Publications, 2013, 43 (4), pp.1160-1168. ⟨10.3892/ijo.2013.2024⟩

International audience; Limited success has been achieved in extending the survival of patients with metastatic and hormone-refractory prostate cancer (HRPC). There is a strong need for novel agents in the treatment and prevention of HRPC. In the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec9dbaea6341f1d129f61b8e5fb96f2
https://pubmed.ncbi.nlm.nih.gov/23877542

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Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells

Autor: David Yannick Leger, Clemence Lepage, Bertrand Liagre, Frederique Martin, Julian Bertrand, Jean-Louis Beneytout

Publikováno v: Cancer letters. 301(2)

Previously, we demonstrated that diosgenin induced apoptosis in colorectal cancer cell lines HCT-116 and HT-29. HT-29 cells have been reported to be one of the most resistant colorectal cancer cell lines to TRAIL-induced apoptosis. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faacf06031195b7a760f1e2116d3e03
https://pubmed.ncbi.nlm.nih.gov/21195543

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