Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Frederik W, Lund"'
Autor:
Anne Sofie Busk Heitmann, Anna Mularski, Christoffer Iversen, Jesper Nylandsted, Frederik W. Lund, Catarina Dias, Adam Cohen Simonsen, Martin Berg Klenow
Publikováno v:
Berg Klenow, M, Iversen, C, Wendelboe Lund, F, Mularski, A, Busk Heitmann, A S, Dias, C, Nylandsted, J & Simonsen, A C 2021, ' Annexins A1 and A2 Accumulate and Are Immobilized at Cross-Linked Membrane-Membrane Interfaces ', Biochemistry, vol. 60, no. 16, pp. 1248-1259 . https://doi.org/10.1021/acs.biochem.1c00126
Rapid membrane repair is required to ensure cell survival after rupture of the plasma membrane. The annexin family of proteins is involved in plasma membrane repair (PMR) and is activated by the influx of Ca2+ from the extracellular medium at the sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8087dd731ce6588c54a9d227ce6aec45
https://doi.org/10.1021/acs.biochem.1c00126
https://doi.org/10.1021/acs.biochem.1c00126
Autor:
Jeanne Garbarino, Meihui Pan, Harvey F. Chin, Frederik W. Lund, Frederick R. Maxfield, Jan L. Breslow
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 12, Pp 2716-2725 (2012)
STARD4, a member of the evolutionarily conserved START gene family, has been implicated in the nonvesicular intracellular transport of cholesterol. However, the direction of transport and the membranes with which this protein interacts are not clear.
Externí odkaz:
https://doaj.org/article/c731a71c1fdc40c0aded5bcc11b35939
Autor:
Martin Berg Klenow, Jesper Nylandsted, Poul Martin Bendix, Himanshu Khandelia, Anna Mularski, Theresa Louise Boye, Stine Lauritzen Sønder, Adam Cohen Simonsen, Frederik W. Lund, Ali Asghar Hakami Zanjani, Catarina Dias, Anne Sofie Busk Heitmann
Publikováno v:
Heitmann, A S B, Zanjani, A A H, Klenow, M B, Mularski, A, Sønder, S L, Lund, F W, Boye, T L, Dias, C, Bendix, P M, Simonsen, A C, Khandelia, H & Nylandsted, J 2021, ' Phenothiazines alter plasma membrane properties and sensitize cancer cells to injury by inhibiting annexin-mediated repair ', Journal of Biological Chemistry, vol. 297, no. 2, 101012 . https://doi.org/10.1016/j.jbc.2021.101012
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Repair of damaged plasma membrane in eukaryotic cells is largely dependent on the binding of annexin repair proteins to phospholipids. Changing the biophysical properties of the plasma membrane may provide means to compromise annexin-mediated repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762986de24e1d386d2da4f6e961eb250
https://findresearcher.sdu.dk:8443/ws/files/191223600/PIIS0021925821008140.pdf
https://findresearcher.sdu.dk:8443/ws/files/191223600/PIIS0021925821008140.pdf
Autor:
Maria Szomek, Christian W. Heegaard, Gerd Schneider, James G. McNally, Stephan Werner, Sergey Kapishnikov, Frederik W. Lund, Maria Louise V. Jensen, Alice Dupont Juhl, Peter Guttmann, Daniel Wüstner
Publikováno v:
Dupont Juhl, A, Lund, F W, Jensen, M L V, Szomek, M, Würtz Heegaard, C, Guttmann, P, Werner, S, McNally, J, Schneider, G, Kapishnikov, S & Wüstner, D 2021, ' Niemann Pick C2 protein enables cholesterol transfer from endo-lysosomes to the plasma membrane for efflux by shedding of extracellular vesicles ', Chemistry and Physics of Lipids, vol. 235, 105047 . https://doi.org/10.1016/j.chemphyslip.2020.105047
Juhl, A D, Lund, F W, Jensen, M L V, Szomek, M, Heegaard, C W, Guttmann, P, Werner, S, McNally, J, Schneider, G, Kapishnikov, S & Wüstner, D 2021, ' Niemann Pick C2 protein enables cholesterol transfer from endo-lysosomes to the plasma membrane for efflux by shedding of extracellular vesicles ', Chemistry and Physics of Lipids, vol. 235, 105047 . https://doi.org/10.1016/j.chemphyslip.2020.105047
Juhl, A D, Lund, F W, Jensen, M L V, Szomek, M, Heegaard, C W, Guttmann, P, Werner, S, McNally, J, Schneider, G, Kapishnikov, S & Wüstner, D 2021, ' Niemann Pick C2 protein enables cholesterol transfer from endo-lysosomes to the plasma membrane for efflux by shedding of extracellular vesicles ', Chemistry and Physics of Lipids, vol. 235, 105047 . https://doi.org/10.1016/j.chemphyslip.2020.105047
The Niemann-Pick C2 protein (NPC2) is a sterol transfer protein in the lumen of late endosomes and lysosomes (LE/LYSs). Absence of functional NPC2 leads to endo-lysosomal buildup of cholesterol and other lipids. How NPC2’s known capacity to transpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76f9478bdad7e701143ad54278647e3
https://pure.au.dk/portal/da/publications/niemann-pick-c2-protein-enables-cholesterol-transfer-from-endolysosomes-to-the-plasma-membrane-for-efflux-by-shedding-of-extracellular-vesicles(7a992662-d6a3-453b-80ce-61a38542a38a).html
https://pure.au.dk/portal/da/publications/niemann-pick-c2-protein-enables-cholesterol-transfer-from-endolysosomes-to-the-plasma-membrane-for-efflux-by-shedding-of-extracellular-vesicles(7a992662-d6a3-453b-80ce-61a38542a38a).html
Autor:
Christer S. Ejsing, Alice Dupont, Zane Berzina, Ahmed S Mehadi, Frederik W. Lund, Maria Szomek, Maria Louise V. Jensen, Maciej Modzel, Christian W. Heegaard, Lukasz M. Solanko, Katarzyna A. Solanko, Gitte Nielsen, Daniel Wüstner
Publikováno v:
Berzina, Z, Solanko, L M, Mehadi, A S, Jensen, M L V, Lund, F W, Modzel, M, Szomek, M, Solanko, K A, Dupont, A, Nielsen, G K, Heegaard, C W, Ejsing, C S & Wüstner, D 2018, ' Niemann-Pick C2 protein regulates sterol transport between plasma membrane and late endosomes in human fibroblasts ', Chemistry and Physics of Lipids, vol. 213, pp. 48-61 . https://doi.org/10.1016/j.chemphyslip.2018.03.006
Niemann-Pick disease type C2 is a lipid storage disorder in which mutations in the NPC2 protein cause accumulation of lipoprotein-derived cholesterol in late endosomes and lysosomes (LE/LYSs). Whether cholesterol delivered by other means to NPC2 defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c02ec4c11006c8cf925d96428d0c0f
https://doi.org/10.1016/j.chemphyslip.2018.03.006
https://doi.org/10.1016/j.chemphyslip.2018.03.006
Publikováno v:
Molecular Biology of the Cell
The kinetics of sterol transport between the plasma membrane and the endocytic recycling compartment is measured using fluorescence microscopy. STARD4, a small, soluble sterol transport protein, is responsible for 25% of the total transport and 33% o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f744708d45d7912b76dac7725e90ad4b
https://doi.org/10.1091/mbc.e16-07-0499
https://doi.org/10.1091/mbc.e16-07-0499
Publikováno v:
J Cell Sci
Low-density lipoprotein (LDL) deposition, aggregation and retention in the endothelial sub-intima are critical initiating events during atherosclerosis. Macrophages digest aggregated LDL (agLDL) through a process called exophagy. High-density lipopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699d6f47d24f9257d46e88db73486665
https://pubmed.ncbi.nlm.nih.gov/31719160
https://pubmed.ncbi.nlm.nih.gov/31719160
Publikováno v:
Wüstner, D, Lund, F W, Röhrl, C & Stangl, H 2016, ' Potential of BODIPY-cholesterol for analysis of cholesterol transport and diffusion in living cells ', Chemistry and Physics of Lipids, vol. 194, pp. 12-28 . https://doi.org/10.1016/j.chemphyslip.2015.08.007
Cholesterol is an abundant and important lipid component of cellular membranes. Analysis of cholesterol transport and diffusion in living cells is hampered by the technical challenge of designing suitable cholesterol probes which can be detected for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f747644b2a1a6f80bd09d49376e6f202
https://doi.org/10.1016/j.chemphyslip.2015.08.007
https://doi.org/10.1016/j.chemphyslip.2015.08.007
Autor:
Mohammad Reza Arastoo, Catarina Dias, Helena Maria D. Danielsen, Mayank Prakash Pandey, Jesper Nylandsted, Ali Asghar Hakami Zanjani, Anne Sofie Busk Heitmann, Anna Mularski, Himanshu Khandelia, Christoffer D. Florentsen, Swantje Christin Häger, Stine Lauritzen Sønder, Guillermo Moreno-Pescador, Poul Martin Bendix, Frederik W. Lund, Adam Cohen Simonsen, Martin Berg Klenow
Publikováno v:
Bendix, P M, Simonsen, A C, Florentsen, C D, Häger, S C, Mularski, A, Zanjani, A A H, Moreno-Pescador, G, Klenow, M B, Sønder, S L, Danielsen, H M, Arastoo, M R, Heitmann, A S, Pandey, M P, Lund, F W, Dias, C, Khandelia, H & Nylandsted, J 2020, ' Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair ', Cells, vol. 9, no. 4, 1029 . https://doi.org/10.3390/cells9041029
Cells, Vol 9, Iss 1029, p 1029 (2020)
Cells
Cells, Vol 9, Iss 1029, p 1029 (2020)
Cells
The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee41d1e0a9f4851c2c98017fa030a21
https://doi.org/10.3390/cells9041029
https://doi.org/10.3390/cells9041029
Autor:
Gerd Schneider, Frederik W. Lund, Christian W. Heegaard, Maria Szomek, Peter Guttmann, Jensen Mlv, Stephan Werner, Sergey Kapishnikov, Alice Dupont, Daniel Wüstner, Gitte Nielsen, James G. McNally
Publikováno v:
Dupont, A, Lund, F W, Jensen, M L V, Szomek, M, Nielsen, G K, Heegaard, C W, Guttmann, P, Werner, S, McNally, J, Schneider, G, Kapishnikov, S & Wüstner, D 2018, ' Analysis of cholesterol export from endo-lysosomes by Niemann Pick C2 protein using combined fluorescence and X-ray microscopy ', BioRxiv . https://doi.org/10.1101/462481
The Niemann-Pick C2 protein (NPC2) is a sterol transfer protein in late endosomes and lysosomes (LE/LYSs). How its capacity to transport cholesterol between membranes is linked to endo-lysosomal membrane trafficking is not known. Using quantitative f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd3096ad61c2cfde97d8e811823a71f
https://portal.findresearcher.sdu.dk/da/publications/427dd2f1-8c32-4763-835e-9fc2f75af605
https://portal.findresearcher.sdu.dk/da/publications/427dd2f1-8c32-4763-835e-9fc2f75af605